Protein Alignment CG43373 and GUCY1B1

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 132/589 - (22%)
• Similarity: 218/589 - (37%)
• Gaps: 219/589 - (37%)

  Fly   416 EKRSLQD--AGLVKGGGIQ--------------------TQLIVDTATDDDADVYTVASDDDDDV 458
            |:..|||  .|::|....|                    ||.:::.....:.|.|       :|:
Human   138 EREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFY-------EDL 195

  Fly   459 DGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPL-ILMQVDE 522
            |.....|::.          ::||                       |..:.:..|. |:...|
Human   196 DRFEENGTQE----------SRIS-----------------------PYTFCKAFPFHIIFDRD- 226

  Fly   523 SVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLV-----SYVILGTFLAIEVAVSYAMQPSKS 582
                  :|:..||               |.|:.||.     :..:|..|..:...:..      |
Human   227 ------LVVTQCG---------------NAIYRVLPQLQPGNCSLLSVFSLVRPHIDI------S 264

  Fly   583 FNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHL----------YTCLRLNAMQDEAVEMIH 637
            |:|     :|.::. |:..||.:|.     ||.|..|          .:||||..      :||:
Human   265 FHG-----ILSHIN-TVFVLRSKEG-----LLDVEKLECEDELTGTEISCLRLKG------QMIY 312

  Fly   638 WEE-----LLCTLVALLLANLT--GVY-THWPKEKAQRKAFI-------ETRQCIEARLRTQR-- 685
            ..|     .||:...:.|.:||  |:| :..|...|.|...:       |.:...|..:.|.|
Human   313 LPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQ 377

  Fly   686 ------ENQQQE---------------------------------------------RLLLSVLP 699
                  |:::::                                             |||.||||
Human   378 LTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLP 442

  Fly   700 RHVAMEMKDDIAGQPRDTQFHK--IYIQRHENVSILFADICGFTSLSDQCTAEE----LVRLLNE 758
            ..||.|::            ||  :..:|::||:|||:.|.||.:...:..:.|    :|.|||:
Human   443 PSVANELR------------HKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLND 495

  Fly   759 LFARFDRLAAEH---HCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVN 820
            |:.|||.|....   ...:::.:||.|..|||||||...||.....:.|||::....| :|...:
Human   496 LYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGES 559

  Fly   821 VNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCL------DGD 879
            |.:.:|||||.|..||:|....::.::.|.|.|.:..|:.|..|::::::.|.:||      |..
Human   560 VQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQ 624

  Fly   880 YEVE 883
            :.:|
Human   625 FHLE 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	53/279 (19%)
		CYCc	686..881	CDD:214485	69/254 (27%)
		Guanylate_cyc	722..895	CDD:278633	57/175 (33%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572	7/27 (26%)
		HNOBA	207..449	CDD:311573	58/309 (19%)
		Guanylate_cyc	455..648	CDD:306677	57/175 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810