DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	309	Identity:	78/309 - (25%)
Similarity:	135/309 - (43%)	Gaps:	94/309 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 KEKAQRKAFIE-TRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQ 725
            |...:.||.:| |.|.:|      .|.::...||.|:.|..||.::          .|..::..:
Human   467 KRMDKLKATLERTHQALE------EEKKKTVDLLYSIFPGDVAQQL----------WQGQQVQAR 515

  Fly   726 RHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHC-----LRIKLLGDCYYCV 785
            :.::|::||:||.|||::..|||..:::.:||||:.|||     |.|     .:::.:||.|...
Human   516 KFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFD-----HQCGFLDIYKVETIGDAYCVA 575

  Fly   786 SGLPEPRPDHAHCAVEMGLDMIDAIALVREVMA------------------VNV----------- 821
            :||......||.....|.|.|::   |..||:.                  |::
Human   576 AGLHRKSLCHAKPIALMALKMME---LSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSET 637

  Fly   822 -----NMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYE 881
                 .||:|||:|.|..||:|:...::.::.|:||||:..|||..|.|::::..|.:.|..:
Human   638 DLGTEKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKRE-- 700

  Fly   882 VEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKEL 930
                              |::..:|          |:|.::..|..||:
Human   701 ------------------ESFTFIP----------RSREELPDNFPKEI 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	15/58 (26%)
		CYCc	686..881	CDD:214485	64/233 (27%)
		Guanylate_cyc	722..895	CDD:278633	56/211 (27%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002
		HNOBA	316..503	CDD:285003	12/41 (29%)
		CYCc	485..705	CDD:214485	65/257 (25%)
		Guanylate_cyc	514..729	CDD:278633	63/246 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810