DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy8

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_058838.1	Gene:	Adcy8 / 29241	RGDID:	2036	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	1334	Identity:	482/1334 - (36%)
Similarity:	689/1334 - (51%)	Gaps:	268/1334 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 QMTRGSSIPLLALAS------------------NGSWAGNGAVGGELKSAHNHNIADFEADH--N 379
            |::..|.:||.:|.|                  :||.:|:|. ||:|...| .:.|...:|.  |
  Rat    79 QLSSDSVLPLYSLGSGERAHNTGGTKVFPERSGSGSASGSGG-GGDLGFLH-LDCAPSNSDFFLN 141

  Fly   380 GQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDD 444
            |...:|.......|...|.|...:.:|    ||.:.::|             :::::::.
  Rat   142 GGYSYRGVIFPTLRNSFKSRDLERLYQ----RYFLGQRR-------------KSEVVMNV----- 184

  Fly   445 ADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGY 509
            .||.|                  .:|..                ||:.|    :|:...||..|.
  Rat   185 LDVLT------------------KLTLL----------------VLHLS----LASAPMDPLKGI 211

  Fly   510 GQLIPLILMQVDESVLVFL--IVMLICGIVYAFLLCILSKPAMNEIFLV---LVSYVILGTFLAI 569
                          :|.|.  |.::||.:|      ::.|...:..:|.   :|::|.:.|.: :
  Rat   212 --------------LLGFFTGIEVVICALV------VVRKDTTSHTYLQYSGVVTWVAMTTQI-L 255

  Fly   570 EVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGI---LLSVVHLYTCLRLNAMQDE 631
            ...:.|.:..    :|....:..::.||:||||.|..|::.|:   ||.|.......||
  Rat   256 AAGLGYGLLG----DGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRL------ 310

  Fly   632 AVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLS 696
            ||..|:  ::|..:|..:..|..|::..:..::|||:||:|||:|:|||||.:.|||:||||:||
  Rat   311 AVFSIN--QVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLS 373

  Fly   697 VLPRHVAMEMKDD---IAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNE 758
            ||||.|.:||.:|   :..:....|||:|||.|:|||||||||:.|||:||...:|:||||:|||
  Rat   374 VLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNE 438

  Fly   759 LFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNM 823
            |||||||||.||||||||:|||||||||||||||.|||||.|||||.||..|..||.....:|:|
  Rat   439 LFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDM 503

  Fly   824 RVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGN 888
            |:|||:|.|.||||||.||||||||.||.:||.:||||||||:||:|.||.||.|||.||.|.|.
  Rat   504 RIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGHGK 568

  Fly   889 ERNSYLKDHQIETYLI---------VPGDIYRPHKKSRNRLQ-----VNGNISKEL--------- 930
            |||.:|:.|.||||||         :|.||.:......:|..     ..|:.|.||
  Rat   569 ERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQ 633

  Fly   931 -----------RMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQS 984
                       .::.:..||....:.|          || |:|:.:...||.||.|.||.||.:.
  Rat   634 NTLAALTRNSINLLPNHLAQALHVQSG----------PE-EINKRIEHTIDLRSGDKLRREHIKP 687

  Fly   985 LLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLV 1049
            ..|.|||:.||.||:...|.:......|:.:|||..:.::.::..|.|:.:.:....|::|...:
  Rat   688 FSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSAL 752

  Fly  1050 FLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRF 1114
            .|:...:....||..:::....|:.......:..|||:.:..|          |..:.:|
  Rat   753 VLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFL----------GAVINIL----- 802

  Fly  1115 WLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLA 1179
            |.|.:.||.|.:...|:   .|...|...|..|  |:...:|:|::||.:..|..:|||.:||:.
  Rat   803 WCDFDKSIPLKNLTFNS---SAVFTDICSYPEY--FVFTGVLAMVTCAVFLRLNSVLKLAVLLIM 862

  Fly  1180 SGSYMACSSNLY--------SRSREMSQELANEEALLRYIIDSIFLFA-FMLALIFHSHQTEATY 1235
            ...|...:..:|        :.:......|..:||       |:.|.| |:||:.:|..|.|.|.
  Rat   863 IAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEA-------SLLLMAMFLLAVFYHGQQLEYTA 920

  Fly  1236 RLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASI 1300
            ||||:|::||.||..:|:.|:.:|..:|.||||.|||.|||.:::..::||.:..|:|.::||||
  Rat   921 RLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASI 985

  Fly  1301 PNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT--ANTC 1363
            |.|::||.:.|.||:|||||||||||||||||||.|:||:.|||||:.|:||||.|||:  ...|
  Rat   986 PGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQC 1050

  Fly  1364 DRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNV 1428
            :. .:.|:.|:||::|.|.:.|:|:|.||||||.:||||:.|.||||||||.||||||||..||:
  Rat  1051 ED-KWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNL 1114

  Fly  1429 ASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKG----KGSMITYFLKGR---RPIDAK 1486
            ||||||||:...|||.:|...||:.:||....||.:.|||    :|.:.||||.||   .|.
  Rat  1115 ASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPF--- 1176

  Fly  1487 ELELAKTEVEPPKTL----TLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNM 1547
                    :.||:.|    :||.....|                                    :
  Rat  1177 --------ILPPRRLPGQYSLAAVVLGL------------------------------------V 1197

  Fly  1548 QNLTAQRRKSLCRQHNISSSFGTTVSSSTGITPS 1581
            |:|..||:|.|..:::.|....:..:..|.:|||
  Rat  1198 QSLNRQRQKQLLNENSNSGIIKSHYNRRTLLTPS 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	66/207 (32%)
		CYCc	686..881	CDD:214485	136/197 (69%)
		Guanylate_cyc	722..895	CDD:278633	124/172 (72%)
		DUF1053	<949..1005	CDD:283888	22/55 (40%)
		CYCc	1259..1455	CDD:214485	115/197 (58%)
		Guanylate_cyc	1285..1479	CDD:278633	115/199 (58%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269\|PubMed:16258073, ECO:0000269\|PubMed:22494970, ECO:0000269\|PubMed:22976297	1..179		26/118 (22%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269\|PubMed:22976297	1..106		6/26 (23%)
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117		8/37 (22%)
		AC_N	<158..397	CDD:292831	82/331 (25%)
		CYCc	363..561	CDD:214485	136/197 (69%)
		Guanylate_cyc	402..586	CDD:278633	132/183 (72%)
		DUF1053	614..708	CDD:283888	29/104 (28%)
		CYCc	941..1145	CDD:214485	117/204 (57%)
		Guanylate_cyc	970..1169	CDD:278633	115/199 (58%)
		Involved in CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	1106..1248		52/173 (30%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269\|PubMed:19305019	1197..1212		6/14 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1248		4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710