DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Adcy10

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	976	Identity:	169/976 - (17%)
Similarity:	322/976 - (32%)	Gaps:	296/976 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 GVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDD--IAG----- 712
            |...::|  ....|.|:        ||....|:..:..|.|......:.::..||  :.|
Mouse   235 GFMDYYP--SGDHKNFL--------RLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSEL 289

  Fly   713 QPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLL-------NELFARFDRLAAEH 770
            :|....|..:..:..:.|.::.:.|        |.....:..:|       |::| .||:
Mouse   290 RPVTIVFVNLMFKEQDKVEVIGSAI--------QAACVHITSVLKVFRGQINKVF-MFDK----- 340

  Fly   771 HCLRIKLLGDCYYCVSGLP-EPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 834
                    |..:.||.|.| |..||....|:|..:|:.|..:.|.::..|:    :|:.:|.|.|
Mouse   341 --------GCSFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVHKIRTVS----IGVASGIVFC 393

  Fly   835 GVLG-LVKWQFDVWSNDVTLANHM---------------ESGGIPGRV--HITKETLK------- 874
            |::| .|:.::.|....|.:|..|               :...:|...  .:.|:.:|
Mouse   394 GIVGHTVRHEYTVIGQKVNIAARMMMYYPGIVSCDSVTYDGSNLPAYFFKELPKKVMKGVADPGP 458

  Fly   875 ---CLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGHG 936
               ||..:.:|..|.     :||..::.|.|.:: |.:        ..:....:..|:..|....
Mouse   459 VYQCLGLNEKVMFGM-----AYLICNRYEGYPLL-GRV--------REIDYFMSTMKDFLMTNCS 509

  Fly   937 TAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASE 1001
            ....:....|:|.|            :.||      .|::|.::|                   |
Mouse   510 RVLMYEGLPGYGKS------------QVLM------EIEYLASQH-------------------E 537

  Fly  1002 PDRMLCV---------YFYCSLLVLLGTSIMRLVV---FQSSLLTLALSTGALLLLGFLVFLVAC 1054
            ..|.:.:         .||  .:.:|..:::.|..   ::.....|......||...|...|...
Mouse   538 NHRAVAIALTKISFHQNFY--TIQILMANVLGLDTCKHYKERQTNLQNRVKTLLDEKFHCLLNDI 600

  Fly  1055 HKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRF----- 1114
            ..:.|.:..::.|.| :|...:::..||          ..:||......|.:.::...:|
Mouse   601 FHVQFPVSREMSRMS-KIRKQKQLEALF----------MKILAQTVREERIIFIIDEAQFVDGTS 654

  Fly  1115 WLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLA 1179
            |..:...|......:...:....|..|   .|.|..:.....:.::..|.|...|..|:.:.|..
Mouse   655 WAFIEKLIRSMPIFIVMSLAPFSEVPC---AAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSV 716

  Fly  1180 SGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQ 1244
            |           |..||:...|......:.|..:.      :|..:.| |:.       .:::..
Mouse   717 S-----------SIPRELDSYLVEGSCGIPYYCEE------LLKNLDH-HRV-------LLFQQA 756

  Fly  1245 ATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVE 1309
            .||:|.::    .:|.....::.|.             ||:.         ||.||.
Mouse   757 ETEQKTNV----TWNNMFKHSVRPT-------------DDMQ---------LFTSIS-------- 787

  Fly  1310 LEGNNE------GVECLRL-----LNEI-IADFDEL-LSEERF-RCIEKIKSTGATYMAASGL-- 1358
             ||..|      ||....|     |.|| :...|.: ||.:.. ||...|..|..|.:....|
Mouse   788 -EGQKEVCYLVSGVRLNNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPC 851

  Fly  1359 ---------TANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRI--GINIGP------ 1406
                     .|...:...|:...:..|..|.|...:....:| :.:..:::  |:..|.
Mouse   852 WNMKMMIKALATLVESNVFNCFRSSKDLQLALKQNVPTFEVH-YRSLALKLKEGLTYGEEEELRE 915

  Fly  1407 -----VVAGVIGACKP-----QYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQ------------ 1449
                 |...::..|:|     .|::|         :.....|.|::..:.:::
Mouse   916 MEGEVVECRILRFCRPIMQKTAYELW---------LKDQKKVLHLKCARFLEESAHRCNHCRNVD 971

  Fly  1450 ILEGRGFELTCR-GSVDVKGKGSMITYFLKGRRPIDAKELELAKTEV----EPPKTLTLAKEPEK 1509
            .:....|.:..| .::|:.....|:|  .:|.: ||.:|...:|:|:    :.|:.|::.:..||
Mouse   972 FIPYHHFIVDIRLNTLDMDTVKRMVT--SQGFK-IDEEEAIFSKSELPRKYKFPENLSITEIREK 1033

  Fly  1510 L 1510
            :
Mouse  1034 I 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	13/71 (18%)
		CYCc	686..881	CDD:214485	46/237 (19%)
		Guanylate_cyc	722..895	CDD:278633	41/208 (20%)
		DUF1053	<949..1005	CDD:283888	7/55 (13%)
		CYCc	1259..1455	CDD:214485	41/250 (16%)
		Guanylate_cyc	1285..1479	CDD:278633	42/249 (17%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636	37/194 (19%)
		COG3899	485..>959	CDD:226415	96/605 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900