Protein Alignment CG43373 and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_001257640.1
• Gene: Gucy1b2 / 25206
• RGDID: 2770
• Length: 742
• Species: Rattus norvegicus
• Alignment Length: 625
• Identity: 141/625 - (22%)
• Similarity: 246/625 - (39%)
• Gaps: 148/625 - (23%)

  Fly   436 IVDTATDD--DADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGV 498
            |::....|  |.||.....|.:::|:  |:...:|:.:....:.:.||..|:      .|...|.
  Rat   146 IIEAVAKDFFDTDVAMSILDMNEEVE--RTGKKEHVVFLVVQKAHRQIRGAK------ASRPQGS 202

  Fly   499 ATDNSDPPLGYGQL---------IPLILMQVDESVLVFLIVMLICG-------IVY--------- 538
            ....:|.....|.|         ||:...:...|..|...|:...|       .||
  Rat   203 EDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRDTFQPVYPERLWVEEE 267

  Fly   539 ----AFLLCILSKPAM--NEIFLVLVSYV--ILGTFLAIEVAVSYAMQPSKSFNGSACCIVL--- 592
                ||...|:...|:  .:..:.:..||  ||....|::...| .:.|..:||.|:.|..:
  Rat   268 VFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFS-IIHPQVTFNISSICKFINSQ 331

  Fly   593 --IYMTYTMLP--------LRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELL--CTL 645
              :.....|:|        |:||..:|....|..:......:|.::|:.....:|..::.  .|.
  Rat   332 FVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPKLRSLQELEESKMHLSDIAPHDTT 396

  Fly   646 VALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQR--------ENQQQERLLLSVLPRHV 702
            ..|:|.|            .||.|.:|....:|.:....|        |.::.|.||.::||.||
  Rat   397 RDLILLN------------QQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHV 449

  Fly   703 AMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLA 767
            |.::|:.          .|:.....|..:|||:|:..||::...|...::|.:||.::::||||.
  Rat   450 ANQLKEG----------RKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLT 504

  Fly   768 AEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDM-IDAIALVREVMAVNVNMRVGIHTGR 831
            :.|...:::.:||.|..|.|:|.|...||.......|.| |.|..::..|....:.:|||||||.
  Rat   505 SVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGP 569

  Fly   832 VHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLD---------GDYEVEVGKG 887
            |..||:|....::.::.:.|..|:.|||.|:|.:||::....:.|.         |:.||: |||
  Rat   570 VLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVK-GKG 633

  Fly   888 NERNSYLKDHQIETYLIV-------------------------PGDIYR-----PHKKSRNRLQV 922
                      ::.||.::                         ||:..|     |......:...
  Rat   634 ----------KMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRNTDHQQQVY 688

  Fly   923 NG---NISKELRMMGHGTAQKHTSKFGFGDSSESAKDPED 959
            .|   :.|.|:.:.|...|.::::     |:..:...|::
  Rat   689 KGDPADASNEVTLAGSPVAGRNST-----DAVNNQPSPDE 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	51/243 (21%)
		CYCc	686..881	CDD:214485	63/204 (31%)
		Guanylate_cyc	722..895	CDD:278633	57/182 (31%)
		DUF1053	<949..1005	CDD:283888	2/11 (18%)
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	5/16 (31%)
		HNOBA	267..453	CDD:285003	44/198 (22%)
		CYCc	432..622	CDD:214485	62/199 (31%)
		Guanylate_cyc	459..642	CDD:278633	59/193 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810