DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	1641	Identity:	288/1641 - (17%)
Similarity:	483/1641 - (29%)	Gaps:	646/1641 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 DGGRSAGSKHITYTPRVRDYNQ---------ISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIP 514
            :|.|:..::...:..|.||:.:         :..|:......|:|::..::.:||..|
Mouse    39 NGSRTCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTSSSSSSSSSSDLHL------- 96

  Fly   515 LILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILG-----TFLAIEVAVS 574
                                      :||.:..||         |.:..|     .:|.:...:.
Mouse    97 --------------------------VLCTVETPA---------SEICAGEGRESLYLQLHGDLV 126

  Fly   575 YAMQPS------------------------KSFNGSACCIVLIYMTYTMLPLRLREALIGGIL-- 613
            ..::||                        ::.|....|::..|.........|...|:.||.
Mouse   127 RRLEPSERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNV 191

  Fly   614 ------------LSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQ 666
                        ..||...|||.:::::|            |....:.:..|.|......|.:..
Mouse   192 RKGKTQLHKWAERLVVLCGTCLIVSSVKD------------CQTGKMHILPLVGGKIEEVKRRQH 244

  Fly   667 RKAFIET---RQCIEARLRTQRENQQQER-----------------LLLSVLPRHV-------AM 704
            ..||...   .|.......|..|.|:.:|                 ..|..:|.|:       .:
Mouse   245 SLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRMSTVDLSCYSLEEVPEHLFYSQDITYL 309

  Fly   705 EMKDDIAGQPR----DTQFHKIYIQRHENVS--------ILFADICGFTSLSDQCTA-----EEL 752
            .::.:.....|    || .||....:..|:|        :|..:|...|.||..|..     .::
Mouse   310 NLRHNFMQLERPGGLDT-LHKFSQLKGLNLSHNKLGLFPVLLCEISTLTELSLSCNGFHDLPSQI 373

  Fly   753 VRLL---------NELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMID 808
            .:||         |.|.|..|.|.   :..::..||..:.....:||         |...|.|:|
Mouse   374 GKLLNLQTLSLDGNGLTALPDELG---NLRQLTSLGISFNDFRHIPE---------VLEKLTMLD 426

  Fly   809 AIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHME---SGGIPGRVHITK 870
            .:|     ||.|          |:....||.:.....|...|:.: ||::   :..:.|..|||.
Mouse   427 KVA-----MAGN----------RLEVLNLGALTRMSQVKHVDLRM-NHLKTVITENMEGNKHITH 475

  Fly   871 ETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGH 935
            ..|                |::.|.|..:.:..            |..:|....|..:||.:.|.
Mouse   476 MDL----------------RDNQLTDLDLSSLC------------SLEQLHCERNQLRELTLSGF 512

  Fly   936 GTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHL--RAEHCQSLLLCFKDNVLERKY 998
            .....:.|                 .|.  :.|::...:..|  ..|..|:||.|..|      :
Mouse   513 SLRTLYAS-----------------WNR--LTAVNVYPVPSLLTSLELSQNLLECVPD------W 552

  Fly   999 ASEPDRMLCVYFYCSLLVLLGTSI-MRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLP 1062
            |.|..::..:....:||    |.: ||::   |||....|..|              |.....||
Mouse   553 ACEAKKLEILDISHNLL----TEVPMRIL---SSLSLRKLMVG--------------HNHIHVLP 596

  Fly  1063 SDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDT 1127
            :.::...|.:                                           ||:
Mouse   597 ALVEHIPLEV-------------------------------------------LDI--------- 609

  Fly  1128 ELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYS 1192
            :.||.   :..||..|..|.|                  ||              |:..|:|
Mouse   610 QHNTL---SRLPDTLFSKALN------------------LR--------------YLNASAN--- 636

  Fly  1193 RSREMSQELANEEAL----LRYIIDSIFLFAFMLALIFHSH-----------QTEATYRLDFIWK 1242
            ....:....|.||:|    |.|:..::.....:..|:.|.|           ||....:|:   |
Mouse   637 SLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLN---K 698

  Fly  1243 LQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEF- 1306
            |      |.:|.|.....||  ..:|..:|                .|..:..|.|...|.|.|
Mouse   699 L------EQLEELNLSGNKL--TAIPTTIA----------------NCKRLHTLVAHANNISIFP 739

  Fly  1307 ---------YVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANT 1362
                     :|:|..|:        |.||      |:.|.....::.:..||.|.:.   |...|
Mouse   740 EILQLPQIQFVDLSCND--------LTEI------LIPEALPATLQDLDLTGNTNLV---LEHKT 787

  Fly  1363 CDRVNFSHVTAMADYALQLFDKIEE------------------------------VNMHSFNNFR 1397
            .|.  |||:||:         ||::                              |:..:.:||.
Mouse   788 LDM--FSHITAL---------KIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALAMDNFA 841

  Fly  1398 MRIGINIGP---------------VVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEM 1447
            ..:|...|.               .:|.|:      .:...::.|....|.:|.||.|.::....
Mouse   842 EGVGAVYGMFDGDRNEELPRLLQCTMADVL------LEEVQHSTNDTVFMTNTFLVSHRKLGMAG 900

  Fly  1448 QQI--------LEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKELELAKTEVEPPKTLTLA 1504
            |::        :.....:.|...|:.|...|.......:|.:|:...            |..:|.
Mouse   901 QKLGSSALLCYIRPDTADPTSSFSLTVANVGMCQAVLCRGGKPVPLS------------KVFSLE 953

  Fly  1505 KEPEKLDSGTATEKQREQVKEQGSTEQEDD--------------------LLPSPDI-------- 1541
            .:||        |.||  ||:|.:...||:                    :||.|.|
Mouse   954 HDPE--------EAQR--VKDQKAIITEDNKVNGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQ 1008

  Fly  1542 ------------DMNSNMQNLTAQRR--------KSLCRQHNISSSFGTTVSSSTGITPSISNSS 1586
                        :..|.::.:.|.|.        |.||           |::.|.|...:
Mouse  1009 DELLILGNKALWEHLSYLEAVNAVRHVQDPLAAAKKLC-----------TLAQSYGCQDN----- 1057

  Fly  1587 SVVTIGALPAILRGGNPLSNANPNATDSCSECGGAS----KSLATPTAPPRT--LVADLKDEIAR 1645
                :||:...|..|........|........|.||    |....||.|..:  :.::...|::.
Mouse  1058 ----VGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTAALKDTPKPTTPSSSSGIASEFSSEMST 1118

  Fly  1646 DE---KIGLKDSIENLEILLKNNI--------SLSDLSN----KQQQNLRGETSSSTTTTLRKRD 1695
            .|   ::|...|.|:..:.|:.::        ||...|:    ::|.:....:|:.:...|...|
Mouse  1119 SEVSSEVGSTASDEHNTVGLEASLLPRPERRCSLHPASSAGVFQRQPSCATFSSNQSDNGLDSDD 1183

  Fly  1696 TIVSFNVTETVTTTAA---------------PFTS---SSGSSNSSSQQKKRRSVTTIAASFTTS 1742
            .    ...|.|.|..:               |.:|   ...|||:.|:::.|.:...|....:.:
Mouse  1184 D----QPVEGVITNGSRVEVEVDIHCCRGREPESSPPLPKNSSNACSEERARGAGFGIRRQNSVN 1244

  Fly  1743 TTTRLLSNESQSSTQTAPGT-------LESGGSVPGQSSTENSSQDWQPRTASLEPNRSPIKTSQ 1800
            :...|.:|..:...|.:|.|       |.:|..||.:.|..      ....|:..|.|   ||..
Mouse  1245 SGILLPANRDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLN------LIEVATEAPKR---KTGY 1300

  Fly  1801 SMSPIGQLTTEVFVLP 1816
            ..:|......:.||:|
Mouse  1301 FAAPTQLEPEDQFVVP 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	39/270 (14%)
		CYCc	686..881	CDD:214485	50/247 (20%)
		Guanylate_cyc	722..895	CDD:278633	40/197 (20%)
		DUF1053	<949..1005	CDD:283888	11/57 (19%)
		CYCc	1259..1455	CDD:214485	45/258 (17%)
		Guanylate_cyc	1285..1479	CDD:278633	45/256 (18%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	20/105 (19%)
		leucine-rich repeat	285..305	CDD:275380	3/19 (16%)
		leucine-rich repeat	306..332	CDD:275380	5/26 (19%)
		LRR_RI	309..548	CDD:238064	61/314 (19%)
		LRR_8	354..412	CDD:290566	13/60 (22%)
		leucine-rich repeat	356..378	CDD:275380	5/21 (24%)
		leucine-rich repeat	379..401	CDD:275380	5/24 (21%)
		leucine-rich repeat	402..424	CDD:275380	6/30 (20%)
		LRR_8	425..483	CDD:290566	18/89 (20%)
		leucine-rich repeat	425..448	CDD:275380	8/37 (22%)
		LRR_RI	447..714	CDD:238064	77/442 (17%)
		leucine-rich repeat	449..472	CDD:275380	5/23 (22%)
		leucine-rich repeat	474..493	CDD:275380	5/46 (11%)
		leucine-rich repeat	494..513	CDD:275380	5/18 (28%)
		leucine-rich repeat	514..535	CDD:275380	3/39 (8%)
		LRR_8	536..592	CDD:290566	19/82 (23%)
		leucine-rich repeat	536..558	CDD:275380	8/27 (30%)
		leucine-rich repeat	559..581	CDD:275380	7/28 (25%)
		leucine-rich repeat	582..597	CDD:275380	4/28 (14%)
		LRR_8	604..664	CDD:290566	21/149 (14%)
		leucine-rich repeat	604..627	CDD:275380	9/77 (12%)
		leucine-rich repeat	628..653	CDD:275380	9/41 (22%)
		leucine-rich repeat	654..677	CDD:275380	4/22 (18%)
		LRR_8	676..735	CDD:290566	16/85 (19%)
		leucine-rich repeat	678..701	CDD:275380	5/31 (16%)
		leucine-rich repeat	702..724	CDD:275380	7/39 (18%)
		leucine-rich repeat	747..768	CDD:275380	8/34 (24%)
		PP2Cc	816..1065	CDD:238083	47/296 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900