Protein Alignment CG43373 and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_011243363.2
• Gene: Gucy1b2 / 239134
• MGIID: 2660873
• Length: 829
• Species: Mus musculus
• Alignment Length: 989
• Identity: 217/989 - (21%)
• Similarity: 349/989 - (35%)
• Gaps: 303/989 - (30%)

  Fly   616 VVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEAR 680
            ||...|||         :|.:...|:||....|             |.|....|.....:.:.|.
Mouse    22 VVFTNTCL---------IERMVMSEVLCAEYTL-------------KVKMSDTADGVLYEPLRAE 64

  Fly   681 LRTQRENQQ-----QERLLLSVLPRHVAMEMKDDIAG---QPRDTQFHKIY-------------- 723
            .|::|.:.|     :.:.|.|:.....|.:......|   :|.||....:|
Mouse    65 FRSKRTHLQGSAEGRGQFLASLQSTSTAFQRFGKTPGVQLRPGDTTLDTMYGFINTCLQSLVTEK 129

  Fly   724 --------IQRHENVSILFA------DICGFTSLSDQCTA-----EELVRLLNELFARFDRLAAE 769
                    ::....|..:|.      |......:.:.|.|     |.:::|..|.|.:|.:::..
Mouse   130 FGEETWEKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALDVSMEAILKLFGEYFFKFCKMSGY 194

  Fly   770 HHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 834
            ...|| .|.|:....:..|     |..|..:.:....::|.:.                  ||..
Mouse   195 DRMLR-TLGGNLTEFIENL-----DALHSYLALSYQEMNAPSF------------------RVEG 235

  Fly   835 GVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHI-------TKETLKCLDGDYEVE-VGKGNERN 891
            |..|.::..:  :|:...|. |:    :||.:..       |...:..||.:.||| .||
Mouse   236 GADGAMRLHY--YSDRRGLC-HI----VPGIIEAVAKDFFDTDVAMSILDMNEEVERTGK----- 288

  Fly   892 SYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKD 956
               |:|.:  :|:|          .:.|.|:.|                           .....
Mouse   289 ---KEHVV--FLVV----------QKARRQIRG---------------------------AKVNR 311

  Fly   957 PEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTS 1021
            |.|..|      |.|:.      |..|..||..|:.                  |.|:.|..|..
Mouse   312 PRDSEN------IQAKQ------ESLQGTLLRKKER------------------YLSIPVCPGEK 346

  Fly  1022 IMRLVVFQSSLLTLALSTGAL-----------LLLGFLVFLVACHKINFQLPSD----IKRFSLR 1071
            ....||..|.|    |..|.|           |.:...||   |:...|.:..|    :|:..:.
Mouse   347 SHSAVVRASVL----LGKGPLGDTFQPVFPERLWIEEEVF---CNAFPFHVVFDEALRVKQAGVN 404

  Fly  1072 IHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLD-----VNGSISLNDTELNT 1131
            |.                              :.:..:..::|.||     |:..::.|.:.:
Mouse   405 IQ------------------------------KYVPGILTQKFGLDEYFSIVHPQVTFNISSI-- 437

  Fly  1132 KMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMA--CSSNLYSRS 1194
                     |.|  ..:.|:|.|...||..|......:.|:..::.:.|...|.  ||..|.|
Mouse   438 ---------CKF--INSQFILKTRREMMPEAWKSQPTLKLRGQMIWMESLKCMVFMCSPKLRS-- 489

  Fly  1195 REMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDM----EHL 1255
               .|||  ||:.:.  :..|........||..:.|..|...|    ..|..::||::    .||
Mouse   490 ---LQEL--EESKMH--LSDIAPHDTTRDLILLNQQRLAEMEL----SCQLEKKKEELRVLSNHL 543

  Fly  1256 QAYNRK---LLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGV 1317
            ....:|   ||..:||.|||.. |...|.:.....|.|   .|||:.:..|:......    |.:
Mouse   544 AIEKKKTETLLYAMLPEHVANQ-LKEGKKVAAGEFETC---TILFSDVVTFTNICAAC----EPI 600

  Fly  1318 ECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLF 1382
            :.:.:||.:.:.||.|.:   ...:.|:::.|..||...|:....     .||...:|::||.:.
Mouse   601 QIVNMLNSMYSKFDRLTN---IHDVYKVETIGDAYMVVGGVPVPV-----ESHAQRVANFALGMR 657

  Fly  1383 DKIEEV-NMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQE 1446
            ...:|| |..:....::|:||:.|||:|||:|...|:|.::|:.||.||||:|.||.:.:.::..
Mouse   658 ISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPT 722

  Fly  1447 MQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLD 1511
            ..:.||.:|||:..||.::|||||.|.||||  .|.::|.|:|             :...|..|.
Mouse   723 AHRALENKGFEIVTRGEIEVKGKGKMTTYFL--IRNLNATEVE-------------IMGRPSALA 772

  Fly  1512 SGTATEKQREQVKE 1525
            .|......|.|||:
Mouse   773 DGKEASTPRNQVKK 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	24/111 (22%)
		CYCc	686..881	CDD:214485	39/242 (16%)
		Guanylate_cyc	722..895	CDD:278633	36/213 (17%)
		DUF1053	<949..1005	CDD:283888	10/55 (18%)
		CYCc	1259..1455	CDD:214485	59/199 (30%)
		Guanylate_cyc	1285..1479	CDD:278633	64/194 (33%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	29/191 (15%)
		HNOBA	380..566	CDD:400168	51/245 (21%)
		Guanylate_cyc	572..754	CDD:306677	64/198 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810