| Sequence 1: | NP_001097622.2 | Gene: | CG43373 / 39835 | FlyBaseID: | FBgn0263131 | Length: | 1854 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_919431.2 | Gene: | PHLPP1 / 23239 | HGNCID: | 20610 | Length: | 1717 | Species: | Homo sapiens |
| Alignment Length: | 2141 | Identity: | 375/2141 - (17%) |
|---|---|---|---|
| Similarity: | 612/2141 - (28%) | Gaps: | 844/2141 - (39%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 2 SGGPGAGSG-----------GAVAGGVGGGATHIFRSLSSESQKREWSKRLSLRGMRH---GGAA 52
Fly 53 GGPG-GSGTSSLASSKEESKHRKFFSRSASLRQAGSGGGGVGVGGVVGGSGSHQASMELHVPGQE 116
Fly 117 GRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAAGITRCNIDESMDSTNS 181
Fly 182 SSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRLNRIILRLCST 246
Fly 247 HQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTL------LVFTTLQLRRSTSLLLE 305
Fly 306 ISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHN 370
Fly 371 IADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDA--------GLVK 427
Fly 428 GGGIQTQLIVDT----------ATDDDADVYTV---ASDDDDDVDGGRSAGSKHITYTPR----- 474
Fly 475 -------------------VRDYNQISHAERD--------------EVLNTSSNAGVATDNSDPP 506
Fly 507 ----------------------------------LGYGQLIPLILMQVDESVLVFLIVMLICGIV 537
Fly 538 YAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPL 602
Fly 603 R---LREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTH----- 659
Fly 660 WPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYI 724
Fly 725 QRHENVSILFADICGFTSL-SDQCTAEELVRL------------------LNELFARFDRL---- 766
Fly 767 AAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGR 831
Fly 832 VHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKD 896
Fly 897 HQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRM-----MGHGTAQKHTSKFGFGDSSESAKD 956
Fly 957 PEDEVNEYLMRA------------IDARSIDHLRAEHCQ-----SLLLCFKDNVLERKYASEPDR 1004
Fly 1005 M-LCVYFYCSLLVLLGTSIMRL------VVFQSSLLTLALSTGALLLLGFLVF-------LVACH 1055
Fly 1056 KINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNG 1120
Fly 1121 SISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMA 1185
Fly 1186 CSSNLYSRSREM-SQELANEEAL---------LRYIIDSIFLFAFMLALIFHSHQTEATYRLDFI 1240
Fly 1241 WKLQATEEK-EDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFS 1304
Fly 1305 EFYVELEGNNEGV---ECLRLLNEIIADFDELLSEERFRCIEKI--KSTGAT----------YMA 1354
Fly 1355 ASGL----------TANTCD---------------RVNFSHVTAMADYALQLFDKI---EEVNMH 1391
Fly 1392 SFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGF 1456
Fly 1457 ELTCRGSVDVKGKGSMITYFLKGRRPIDAKELELAKTEVEPPKT---LTLAKEPEKLDSGTATEK 1518
Fly 1519 QREQVKEQGSTEQEDDLLPSPDIDMNSNMQN--LTAQRRKSLCRQHNISSSFGTTVSSSTGITPS 1581
Fly 1582 ISNSSSVVTIGALPAILRGGNPLSNANPN----------------ATDS--CSE--CGGASKSLA 1626
Fly 1627 TPTAP---PRTLVADLKDEIARDEKIGLKDSIENLEILLKNNISLSDLSNKQQQNLRGETSSSTT 1688
Fly 1689 TTLRKRDTIVSFNVTETVTTTAAPFTSSSGSSNSSSQQKKRRSVTTIAASF----TTSTTTRLLS 1749
Fly 1750 NESQSSTQTAP--GTLESGG-----------------------SVPGQSSTE------NSSQDWQ 1783
Fly 1784 PRTASLEPNRSPIKTSQSMSPIGQLTTEVFVLPNSRSMVLISSTNGSVSALATGGGGASSP 1844 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| CG43373 | NP_001097622.2 | AC_N | <523..720 | CDD:292831 | 28/204 (14%) |
| CYCc | 686..881 | CDD:214485 | 34/217 (16%) | ||
| Guanylate_cyc | 722..895 | CDD:278633 | 34/195 (17%) | ||
| DUF1053 | <949..1005 | CDD:283888 | 15/72 (21%) | ||
| CYCc | 1259..1455 | CDD:214485 | 42/238 (18%) | ||
| Guanylate_cyc | 1285..1479 | CDD:278633 | 44/236 (19%) | ||
| PHLPP1 | NP_919431.2 | leucine-rich repeat | 1107..1129 | CDD:275380 | 6/33 (18%) |
| PP2Cc | 1168..1420 | CDD:214625 | 51/312 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1458..1510 | 11/80 (14%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1673..1717 | ||||
| PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269|PubMed:21804599 | 1715..1717 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..25 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 41..118 | 22/74 (30%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 136..156 | 8/32 (25%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 252..470 | 38/258 (15%) | |||
| PH_PHLPP-like | 535..631 | CDD:270131 | 19/159 (12%) | ||
| PH | 555..636 | CDD:278594 | 16/128 (13%) | ||
| LRR_RI | 625..929 | CDD:238064 | 75/412 (18%) | ||
| LRR_8 | 638..703 | CDD:290566 | 14/74 (19%) | ||
| LRR 1 | 638..659 | 4/23 (17%) | |||
| leucine-rich repeat | 641..661 | CDD:275380 | 3/22 (14%) | ||
| LRR 2 | 661..682 | 2/20 (10%) | |||
| leucine-rich repeat | 662..692 | CDD:275380 | 8/30 (27%) | ||
| LRR 3 | 692..712 | 6/25 (24%) | |||
| leucine-rich repeat | 693..738 | CDD:275380 | 11/59 (19%) | ||
| LRR_8 | 714..770 | CDD:290566 | 16/110 (15%) | ||
| LRR 4 | 715..736 | 3/29 (10%) | |||
| LRR 5 | 738..760 | 6/51 (12%) | |||
| leucine-rich repeat | 739..761 | CDD:275380 | 5/51 (10%) | ||
| LRR 6 | 761..783 | 5/39 (13%) | |||
| leucine-rich repeat | 762..784 | CDD:275380 | 5/39 (13%) | ||
| LRR 7 | 784..804 | 5/19 (26%) | |||
| leucine-rich repeat | 785..808 | CDD:275380 | 6/22 (27%) | ||
| LRR 8 | 808..831 | 7/30 (23%) | |||
| leucine-rich repeat | 810..832 | CDD:275380 | 7/26 (27%) | ||
| LRR_RI | 814..1074 | CDD:238064 | 58/306 (19%) | ||
| LRR 9 | 832..853 | 2/20 (10%) | |||
| leucine-rich repeat | 833..853 | CDD:275380 | 2/19 (11%) | ||
| leucine-rich repeat | 854..895 | CDD:275380 | 11/42 (26%) | ||
| LRR 10 | 873..894 | 7/20 (35%) | |||
| LRR 11 | 895..916 | 5/20 (25%) | |||
| leucine-rich repeat | 896..918 | CDD:275380 | 5/21 (24%) | ||
| LRR 12 | 918..939 | 4/20 (20%) | |||
| leucine-rich repeat | 919..941 | CDD:275380 | 4/21 (19%) | ||
| LRR 13 | 941..962 | 5/20 (25%) | |||
| leucine-rich repeat | 942..963 | CDD:275380 | 6/20 (30%) | ||
| LRR_8 | 962..1024 | CDD:290566 | 12/84 (14%) | ||
| LRR 14 | 963..984 | 4/22 (18%) | |||
| leucine-rich repeat | 964..987 | CDD:275380 | 3/24 (13%) | ||
| LRR 15 | 987..1008 | 4/20 (20%) | |||
| leucine-rich repeat | 988..1011 | CDD:275380 | 4/22 (18%) | ||
| LRR 16 | 1013..1033 | 5/40 (13%) | |||
| LRR_8 | 1014..1072 | CDD:290566 | 15/95 (16%) | ||
| leucine-rich repeat | 1014..1037 | CDD:275380 | 5/43 (12%) | ||
| LRR 17 | 1037..1058 | 7/37 (19%) | |||
| leucine-rich repeat | 1038..1061 | CDD:275380 | 8/39 (21%) | ||
| LRR 18 | 1061..1082 | 4/20 (20%) | |||
| Interaction with SLC9A3R1. /evidence=ECO:0000269|PubMed:21804599 | 1076..1205 | 40/182 (22%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||