Protein Alignment CG43373 and gcy-34

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_506319.1
• Gene: gcy-34 / 191656
• WormBaseID: WBGene00001554
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 743
• Identity: 164/743 - (22%)
• Similarity: 285/743 - (38%)
• Gaps: 212/743 - (28%)

  Fly   830 GRVHCGVLGLV--KWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNS 892
            |.:|..:..||  |:..|||      ...:|..|.                    |.||.|..|.
 Worm     3 GFIHESIRQLVIRKYGEDVW------LQVLERSGF--------------------ENGKENIVNH 41

  Fly   893 YLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKE--LRMMGHGTAQKHTSKFGFGDSSESAK 955
            |..|  .:||::|            :.:.:...::|:  ..|.| |....::.:.|:.:...|..
 Worm    42 YYSD--TDTYVLV------------DSVSIVLKVTKDQIWEMYG-GFLITYSMEIGWDELVRSMS 91

  Fly   956 -------DPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASE--PDRMLCVYFY 1011
                   |..|.::.:         |||          :.:|.|:....:..|  ||..|.::::
 Worm    92 PNLKGFLDNLDSLHYF---------IDH----------VVYKANLRGPSFRCEENPDGTLMLHYF 137

  Fly  1012 CSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLG----------------FLVFLVACHKINFQ 1060
            .....|.  .|::.||.:.:.|...|.. :|::.|                .::||:.    |.:
 Worm   138 TGRPGLY--HIVKGVVKEVAKLVFNLDI-SLVVQGRTQRSVHMNNGERVEEHVIFLIK----NVE 195

  Fly  1061 LP---SDIKR----------FSLRIHSNRRIS-QLFAFASVALIVLTTLLAMFQESGRQM----- 1106
            .|   ||...          |...|..|.::| |.|:.|.....||.....:.| .|.::
 Worm   196 EPRRDSDTSTTSALTSVEPDFGEIIDDNLKVSLQDFSRALPYHFVLDESCRLVQ-CGDELYNHIP 259

  Fly  1107 -ELLQRRRFWLDVNGSISLNDTELNTKMYDAE-EPDCDFYLAYNTFLLLTLLSMM---------- 1159
             ||||        .|:..|...|:|......: |..|:|..|  .|:|....|.:
 Worm   260 NELLQ--------PGTPILRIFEINRPQIPLDFENICNFINA--VFVLQVKTSPLRKKHMNAMTK 314

  Fly  1160 ---------------SCATYQVLRILLKLLLLLLASGSYM--ACSSNLYSRSREMSQELANEEAL 1207
                           |....|...:.||..:::|::..::  .||..:.|
 Worm   315 EEREQEVEAMEEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTS--------------- 364

  Fly  1208 LRYIIDSIFLFAFMLA----------LIFHSHQTEATYRLDFIWKLQATEEK-EDMEH-LQAYNR 1260
                |:.:..|...|.          ||..:.|..:...::.  :|:|..|: |.|.| |:...:
 Worm   365 ----INELMQFGMRLTAMPLHDATRDLILLNQQRLSDVEVNL--QLEANNEQLETMTHELEVERQ 423

  Fly  1261 K---LLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRL 1322
            |   :|:::||..:|:..||.| ||:...:|    ..::|..:|.|.:.....:..|    .::|
 Worm   424 KTDSILKDMLPRKIAKQLLSGE-HLEPCEYE----ATVMFCDLPAFQQIIPVCQPKN----IVKL 479

  Fly  1323 LNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRV-NFSHVT-AMADYALQLFDKI 1385
            |||:....|.::.   .|.:.|:::...:||..||:...|.:.. |..||. .|...|..:.|.:
 Worm   480 LNEVFFKLDRIVV---LRGVYKVETVSDSYMTVSGIPDYTSEHAENMCHVALGMMWEARSVMDPV 541

  Fly  1386 EEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQ-EMQQ 1449
            .:      ..|.:|||::.|.::|||:|...|:|.::|..|.:||:|:|.|:...||.:. ...:
 Worm   542 NK------TPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSK 600

  Fly  1450 ILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            .:|...||.:.||.::|||:|.:.||||
 Worm   601 AMETGRFEFSPRGRINVKGRGDVETYFL 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454
		Guanylate_cyc	722..904	CDD:425528	19/75 (25%)
		Adcy_cons_dom	<949..1005	CDD:461877	11/64 (17%)
		Guanylate_cyc	1285..1479	CDD:425528	56/196 (29%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:462233	44/226 (19%)
		HNOBA	224..441	CDD:462234	49/248 (20%)
		CYCc	421..609	CDD:214485	55/205 (27%)