Protein Alignment CG43373 and gcy-23

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_500309.3
• Gene: gcy-23 / 191652
• WormBaseID: WBGene00001548
• Length: 1073
• Species: Caenorhabditis elegans
• Alignment Length: 1445
• Identity: 267/1445 - (18%)
• Similarity: 462/1445 - (31%)
• Gaps: 576/1445 - (39%)

  Fly   190 IYQRDETQLLQPGDASN---LEANNPMSSGGG-GGTANG----------------------PVSP 228
            |.|..:.||.|.|...|   :|..|.|..|.. .|.|.|                      .|:.
 Worm    37 ILQLSKEQLTQEGVLGNDFDIEILNQMGCGESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVAK 101

  Fly   229 SISFWFRLN-RIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALI----------L 282
            ..:||   | .::..:.|::.|.:..:.....|..||     ||:.||...|.:          :
 Worm   102 MATFW---NIPVVGYMASSNSFADKTIFKTLARVSLR-----TTNSLAEAAAALIKHYGWNKVAI 158

  Fly   283 ALSCTLLVFTTLQ-------------LRR-------------STSLLLEI---SEIGLDANATVG 318
            |.:...:.|..:|             :|:             ::.||.|:   :.:.:.|.::..
 Worm   159 ATNTGAVAFERVQSFEEVFHQRGINVVRKIMLEEYTNAKAIMNSGLLQELENSARVVVCAFSSTR 223

  Fly   319 NLTTATMKPPTLASSDQMTRGSSIPLLALASN--GSWAGNGAVGGELKSAHNHNIADFEA----- 376
            ::....|:..||:..:.......:|.|.|.:.  ..|.|.   .||    :..|:.|..|
 Worm   224 DMNKEFMQAVTLSGMNNANYAWILPWLQLETKDMAPWLGE---NGE----YQQNVKDHFANSFII 281

  Fly   377 -DHNG---QLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIV 437
             |.||   .||                          |.::.|          ::..|..|
 Worm   282 DDVNGFDNTLV--------------------------TPFKER----------LEASGYST---- 306

  Fly   438 DTATDDDADVYTVASDDDDDVDGGRSAGSKHI-----TYTPRVR-----DYNQISHAERDEVLN- 491
                              ||::.....|..|:     .|...||     ..|:.|:....||.|
 Worm   307 ------------------DDLEMKNIYGYIHLYDALRLYALAVRATMNETGNENSYLNGKEVWNH 353

  Fly   492 --------TSSNAGVAT---------------------DNSDPPLGYGQLIPLILMQVDESVLVF 527
                    ..|||||.:                     .|||......:|.|::|...|
 Worm   354 MRRITFPGLVSNAGVTSGTVMMDDIAERAPVYAAFYVPPNSDTVRKVCELEPVMLTNCD------ 412

  Fly   528 LIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVL 592
                              .....|..:.:.|:.:..|.:.:|:.::. |.:|:..|....|
 Worm   413 ------------------GTKTGNGCYELQVTDLSTGFWPSIDGSLP-ADEPACGFRNEKC---- 454

  Fly   593 IYMTYTMLPLRLREALIGG-ILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGV 656
               .||.|       :||| |:|.::.|..|..:.:.             :|...|  |||
 Worm   455 ---DYTTL-------IIGGCIVLLIILLIICFFILSR-------------VCENRA--LAN---- 490

  Fly   657 YTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLL----------LSVLPRHVAMEMKDDIA 711
             |.|   :..|..|           ||.:||:.:..|.          :|:..:|.|      :.
 Worm   491 -TPW---RIYRDDF-----------RTIQENEMKSMLSIGSSKTKMSNMSMFVKHHA------VV 534

  Fly   712 GQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 776
            |......|| :|.||.   .|:|             ..::| :|||::      ..|.|..|. .
 Worm   535 GTNTHASFH-LYPQRR---PIVF-------------NRQDL-QLLNQM------KQAVHDNLN-P 574

  Fly   777 LLGDCY-----------YCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTG 830
            .||..:           :|..|..:....:.    |:.||.....|.:|::       .:|:.
 Worm   575 FLGMSFNEKEEMVVLWKFCSRGTIQDMIYNQ----EVSLDSKFHGAFIRDI-------TLGLE-- 626

  Fly   831 RVHCGVLG----LVKWQFDVWSN------DVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVG 885
            .:|..::|    |..|...:..|      |..:||.:|.....|.  |:.||||  :||.:
 Worm   627 YLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGL--ISTETLK--EGDDK---- 683

  Fly   886 KGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDS 950
            .|:.:.:.|              :|:|.:..:|:      .|...|.|.....::..::...||.
 Worm   684 SGSAQKTSL--------------LYQPPEMLKNK------ESNRTRRMDQSWVKQSQARRQMGDI 728

  Fly   951 SESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLL 1015
            .....    .::|.|.||:...:
 Worm   729 YAFGM----VMHEILFRALPFPN------------------------------------------ 747

  Fly  1016 VLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQ 1080
               ||::..::.:                                :....|.|...:|...:|..
 Worm   748 ---GTNVSEVMDY--------------------------------IRDGTKTFRPTVHDRTQIHP 777

  Fly  1081 LFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYL 1145
                   .|:.|  ||..:.|:......::|.|               |||:
 Worm   778 -------DLVAL--LLDCWNENPEVRPSIRRVR---------------LNTE------------- 805

  Fly  1146 AYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELANEEALLRY 1210
                                                :|:....:|..:...|.::.||.  |.:.
 Worm   806 ------------------------------------NYLKVKGSLVDQMMRMMEQYANN--LEKL 832

  Fly  1211 IIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHF 1275
            :.:...:.            .||..|.|                      |||..:||.:||...
 Worm   833 VAERTGML------------EEANVRAD----------------------KLLGQLLPKYVANEL 863

  Fly  1276 LSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFR 1340
                |....:..:..|...::|:.|..|:    .:..::..:|.:.:||.|.:.||:.:::..
 Worm   864 ----KMGRSVPAKTFDMATVMFSDIVGFT----TICSSSTPLEVVSMLNSIYSKFDDAINKHG-- 918

  Fly  1341 CIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNM-HSFN-NFRMRIGIN 1403
             ..|:::.|..||..||:.....:    .|:..:.:.||:|...::...: |..| ..|:|:||:
 Worm   919 -SYKVETIGDAYMIVSGIPEENGN----EHIRNICNTALELMLLLKTYEIPHRRNVKLRIRLGIH 978

  Fly  1404 IGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQ--ILEGRGFELTCRGSVDV 1466
            .|.|.|||:|...|:|.::|:.|||||||:||...:.||::||.:.  :.....|::|.||:|:.
 Worm   979 TGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSEFQITLRGTVEA 1043

  Fly  1467 KGKGSMITYFLKGRR 1481
            ||||.:.:|:|.|::
 Worm  1044 KGKGPVTSYWLLGKQ 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	36/207 (17%)
		CYCc	686..881	CDD:214485	48/225 (21%)
		Guanylate_cyc	722..895	CDD:278633	40/193 (21%)
		DUF1053	<949..1005	CDD:283888	5/55 (9%)
		CYCc	1259..1455	CDD:214485	56/199 (28%)
		Guanylate_cyc	1285..1479	CDD:278633	59/197 (30%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	79/441 (18%)
		ANF_receptor	38..385	CDD:279440	74/419 (18%)
		PK_GC	509..806	CDD:270894	76/522 (15%)
		HNOBA	<817..863	CDD:285003	15/81 (19%)
		CYCc	842..1035	CDD:214485	61/229 (27%)
		Guanylate_cyc	869..1056	CDD:278633	59/197 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810