DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gcy-21

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	236	Identity:	74/236 - (31%)
Similarity:	128/236 - (54%)	Gaps:	18/236 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1247 EEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELE 1311
            |..|::|..:|.:..||:.:||..||:..    |...::..|..::..:.|:..|.|    ||:.
Worm   910 ERNEELEGEKAKSEALLKMMLPEVVADSL----KLGSNVSAESFENCTVFFSDCPGF----VEMS 966

  Fly  1312 GNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMAD 1376
            ..::.::.::.||::...||.::  ::|. :.|:::....||.||||.....:.    |...:|.
Worm   967 ATSKPIDIVQFLNDLYTVFDRII--DQFD-VYKVETIADAYMVASGLPVPNGNH----HAGEIAS 1024

  Fly  1377 YALQLFDKIEEVNMHSFNN--FRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVD 1439
            ..|.|...:|...:....|  .|:|||:|.||.||||:|...|:|.::|:.||.||||:|.|:..
Worm  1025 LGLALLKAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPL 1089

  Fly  1440 HIQVTQEMQQILEG-RGFELTCRGSVDVKGKGSMITYFLKG 1479
            .|..:...::||:. .|:|:..||.|::||||..:|||::|
Worm  1090 RINCSGTAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVRG 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485	57/198 (29%)
		Guanylate_cyc	1285..1479	CDD:278633	62/196 (32%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822
		PK_GC	612..881	CDD:270894
		HNOBA	<890..938	CDD:400168	10/27 (37%)
		Guanylate_cyc	944..1130	CDD:306677	62/196 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810