DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and gcy-13

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	63/215 - (29%)
Similarity:	114/215 - (53%)	Gaps:	23/215 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 ENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAE 750
            |.::.:.||..:||:.||..:|...:.:|          :..|:|:|.|:|:.|||.|:::.|..
Worm   809 EKKKSDILLYRMLPQQVAERLKLGQSVEP----------EAFESVTIFFSDVVGFTVLANKSTPL 863

  Fly   751 ELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPR-PDHAHCAVEMGLDMIDAIAL-- 812
            ::|.|||:|:..||.:..::...:::.:||.|..|||||... .:|......|.|:::|::..
Worm   864 QVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFK 928

  Fly   813 VREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITK---ETLK 874
            :..:....|.:|:|:|:|....||:||...::.::.:.|..|:.|||.|.||.:|::.   :.|.
Worm   929 IPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLT 993

  Fly   875 CLDGDYEVE-------VGKG 887
            .|..:|..|       .|||
Worm   994 SLYKEYNTESRGEVIIKGKG 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	9/33 (27%)
		CYCc	686..881	CDD:214485	58/200 (29%)
		Guanylate_cyc	722..895	CDD:278633	54/179 (30%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347
		ANF_receptor	13..368	CDD:279440
		PKc_like	548..770	CDD:304357
		HNOBA	<797..829	CDD:285003	7/19 (37%)
		CYCc	808..1000	CDD:214485	58/200 (29%)
		Guanylate_cyc	835..1022	CDD:278633	55/189 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810