DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gcy-3

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_496037.1	Gene:	gcy-3 / 191641	WormBaseID:	WBGene00001530	Length:	1140	Species:	Caenorhabditis elegans

Alignment Length:	644	Identity:	140/644 - (21%)
Similarity:	256/644 - (39%)	Gaps:	134/644 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   942 TSKFGFGDSSESAKD--------PEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKY 998
            |.||.:.:.:::..|        ..:.:|:::..:||:       ::......||.:.::|:..|
Worm   591 TMKFQYMNLNKADMDKFVKLRKLDHENLNKFIGLSIDS-------SQFISVTKLCSRGSLLDILY 648

  Fly   999 ASEPDRMLCVYFYCSL------LVLLGTSIMRLVVFQSSLLTLALSTGALLL--LGFLVFLVAC- 1054
            ... ..|...:.||.:      :..|..|.:||.....|...|...:..:.|  .||...|...
Worm   649 KGN-FSMDFFFMYCIIKDVAEGMSYLHKSFLRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEEIT 712

  Fly  1055 ---HKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWL 1116
               .::.:..| ::.|.||.:......:.:|:||.:|..:||...|        .:|.:|:..:.
Worm   713 PTKRRLLWAAP-EVLRGSLTVSQMDPSADVFSFAIIASEILTRKEA--------WDLKERKEGYD 768

  Fly  1117 DV------NGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLL 1175
            ::      .||..:....:      .:.||.:          .||::::.....:
Worm   769 EIIYRVKKGGSFPIRPDII------TDVPDVN----------PTLIALVKDCWAE---------- 807

  Fly  1176 LLLASGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFI 1240
                :......:.|:..:.|::..:..:.      ::|.:|   .||.....:.:.|...|..
Worm   808 ----APEDRPTAENICEQLRDLMPKTKSN------LMDHVF---NMLEEYTSTLEVEVEERTK-- 857

  Fly  1241 WKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSE 1305
             :|...::|.|:         ||..:||..|||    |.|....:..|..|||.:.|:.:..|:
Worm   858 -ELTLEKKKADL---------LLSRMLPKQVAE----RLKAGQTVEPEGFDSVTVFFSDVVKFT- 907

  Fly  1306 FYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSH 1370
               .|.......:.:.|||::.::||.::.|..   :.|::|.|..|:..|||..    |..|:|
Worm   908 ---ILASKCTPFQVVNLLNDLYSNFDTIIEEHG---VYKVESIGDGYLCVSGLPT----RNGFNH 962

  Fly  1371 VTAMADYALQLFDKIEEVNMHSFNNFR--MRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMD 1433
            :..:.|.:|:..|..:...:......|  :|||:|.||.||||:|...|:|.::|:.||.||||:
Worm   963 IKQIVDMSLKFMDYCKNFKIPHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRME 1027

  Fly  1434 STGLVDHIQVTQEMQQILE---GRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKELELA-KTE 1494
            |.|....|.:|.:...:|.   ...:|...||.|.:||||.|.|:::.||    :.::|.: ...
Worm  1028 SNGKPSLIHLTSDAHLLLMKHFPHQYETNSRGEVIIKGKGVMETFWVLGR----SGDIEPSISNR 1088

  Fly  1495 VEPPKTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQ 1553
            ..||.|      .|:.........:...|...||         .|..:.|:|...|..|
Worm  1089 STPPVT------QERFTVRAPDTPEARSVSSHGS---------RPSSNHNNNNDPLYRQ 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888	8/63 (13%)
		CYCc	1259..1455	CDD:214485	61/200 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	62/198 (31%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347
		ANF_receptor	54..433	CDD:279440
		PKc_like	554..823	CDD:304357	44/278 (16%)
		HNOBA	<839..882	CDD:285003	14/58 (24%)
		CYCc	861..1051	CDD:214485	63/213 (30%)
		Guanylate_cyc	888..1076	CDD:278633	62/198 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810