Protein Alignment CG43373 and gcy-1

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_496039.1
• Gene: gcy-1 / 191639
• WormBaseID: WBGene00001528
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 702
• Identity: 155/702 - (22%)
• Similarity: 266/702 - (37%)
• Gaps: 182/702 - (25%)

  Fly   859 SGGIPGRVHITKE----TLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNR 919
            ||....|..|..|    ..|.::.:.:|. |||..|.|......|.|              ..:.
 Worm   520 SGKRAERARINAEWQVPFAKLIESEKQVR-GKGASRRSLQSAPSIST--------------GHSG 569

  Fly   920 LQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQS 984
            :....:..:...||.:......|:|:.:...:::.|:          |.:..|.:||........
 Worm   570 VTTVSDFCENYTMMMYEKEMVLTAKYQYTHLTKADKE----------RFVKMRKLDHENINRFIG 624

  Fly   985 LLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLV 1049
            |.:             :....:.|...||               :.||..: ||.|...:..|.:
 Worm   625 LSI-------------DSAHFISVTKLCS---------------RGSLQDI-LSRGNFSMDYFFM 660

  Fly  1050 FLVACHKINFQLPSDI--------KRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQM 1106
            |.:.         .|:        |.| ||:|.|.|        |...:|..:......|.|  |
 Worm   661 FCII---------RDVAKGLEYLHKTF-LRLHGNLR--------SATCLVNDSWQVKLAEYG--M 705

  Fly  1107 ELL-------QRRRFWLD---VNGSISLNDTELNTKMY-------------------DAEEPDCD 1142
            :.|       ::|..|:.   :.||:|::..|.:..:|                   |.:| ||:
 Worm   706 DNLVEEQTPPKKRLLWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILDRKE-DCE 769

  Fly  1143 FYLAYNTFL--LLTLLSMMSCATYQVLRILLKLLLLLLASGSYMAC----------SSNLYSRSR 1195
             .:.||...  |..:...:....:.|...|:.|:         ..|          :.|:.|:.:
 Worm   770 -EIVYNVKKGGLFPIRPEIITDIHDVNPALIALV---------KDCWAEVPEDRPTAENICSQMK 824

  Fly  1196 EM-SQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYN 1259
            .: |::..|       ::|.:|   .||.....:.:.|...|..   :|...::|.|:
 Worm   825 GLVSKQKTN-------LMDHVF---NMLEEYTSTLEEEIEERTK---ELTLEKKKADI------- 869

  Fly  1260 RKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLN 1324
              ||..:||..|||    |.|....:..|..|||.:.|:.:..|:    .|.......:.:.|||
 Worm   870 --LLSRMLPKQVAE----RLKAGQTVEPEGFDSVTVFFSDVVKFT----ILASKCSPFQTVNLLN 924

  Fly  1325 EIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVN 1389
            ::.::||.::.:..   :.|::|.|..|:..|||..    |..::|:..:.|.:|:..:..:..|
 Worm   925 DLYSNFDTIIEQHG---VYKVESIGDGYLCVSGLPT----RNGYAHIKQIVDMSLKFMEYCKSFN 982

  Fly  1390 MHSF--NNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILE 1452
            :...  .|..:|||:|.||.||||:|...|:|.::|:.||.||||:|.|....|.:|.:...:|.
 Worm   983 IPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLT 1047

  Fly  1453 ---GRGFELTCRGSVDVKGKGSMITYFLKGR-RPIDAKELELAKTEVEPPKT 1500
               ...:|.:.||.|.:||||.|.|:::.|| ..::..||........||.|
 Worm  1048 THYPNQYETSSRGEVIIKGKGVMETFWVHGRFGEMEPTELRSISNRSTPPVT 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454
		Guanylate_cyc	722..904	CDD:425528	14/48 (29%)
		Adcy_cons_dom	<949..1005	CDD:461877	6/55 (11%)
		Guanylate_cyc	1285..1479	CDD:425528	60/198 (30%)
gcy-1	NP_496039.1	PBP1_NPR_GC-like	35..451	CDD:380575
		Protein Kinases, catalytic domain	555..821	CDD:473864	56/349 (16%)
		HNOBA	<839..883	CDD:462234	15/62 (24%)
		CYCc	862..1051	CDD:214485	61/212 (29%)