DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and phlp-2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	1271	Identity:	222/1271 - (17%)
Similarity:	389/1271 - (30%)	Gaps:	445/1271 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   733 LFADICGFTSLSDQ-CTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHA 796
            :..|.|...::||: ...|...:.|.::.:..|..|..|          .:....|.|..|....
Worm    81 ILQDFCRILTMSDENLETESTSKALEDILSYTDSPAFRH----------IFSFFLGRPRIRAKST 135

  Fly   797 HCAVEMGLDMIDAIALVREVMAVNV----------------------------NMRVGIH---TG 830
                 :.||::....::|:...::.                            ||:|.:|   .|
Worm   136 -----LNLDILSEEVVIRKGKLIHTWQNARAVFYNSNIRLQTKNNQDEALQIRNMKVDVHESKRG 195

  Fly   831 RV----HCGVLGLVKWQ----FDVW---SNDVTLANHMESGG-----IPGRVHITKETLKCLDGD 879
            |.    ...|..|:.:|    .:.|   :..|..:||:::..     ||.::         |:.:
Worm   196 RALRLKDDDVCYLIIFQRPNILEAWLTRAQQVEKSNHVDASDEQLTLIPEQI---------LNNE 251

  Fly   880 YEVEVGKGNERNSYLKDHQIETYLIVPG---DIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKH 941
            ..|:: ....|||.:.....|..:...|   |:||.|.     |||.
Worm   252 ARVQI-LNLRRNSLISRPPTEKSMAPLGYIDDLYRVHS-----LQVI------------------ 292

  Fly   942 TSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRML 1006
                   |.|         .|:.|...|....:.|||           :.|:.....:|.|..
Worm   293 -------DLS---------ANQILSFPIQLTLLSHLR-----------QLNLSSNYISSVPSE-- 328

  Fly  1007 CVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRF--- 1068
                 |        |.||.:.:      |.||...|                ..||..|...
Worm   329 -----C--------SNMRRLQY------LNLSNNQL----------------DTLPDSISELQNL 358

  Fly  1069 -SLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTK 1132
             ||.|..|:       |:.:...:....|.|::.:|..:|.:.|       .|.:.:...:|...
Worm   359 QSLDISFNQ-------FSQIPPCLFHLTLEMWRLAGNNIEKIDR-------VGEMQIQKIDLRRN 409

  Fly  1133 MYDAEEPDCDFYLAYNTFLLLTLL--SMMSCATYQVLRILLKLLLLLLASGSYMACS----SNLY 1191
            :.|.     .|.|.......|.|.  ||:|......||.|           ..:.|.    |:|:
Worm   410 VLDT-----SFRLDIENITHLDLRDNSMISTVHLTNLRFL-----------KVIHCERLQLSSLH 458

  Fly  1192 SRSREMSQELANEEALLRYIIDSIFLFAF-----MLALIFHSHQTEATYRLDFIWKLQATEEKED 1251
            .....::...|:..     ::||:.:...     .|:|.|:..:...    |:|      .:..:
Worm   459 LSGESLTHVYADHN-----LLDSLVVMPLPQNLQTLSLSFNHFRNLP----DWI------SDCPN 508

  Fly  1252 MEHLQAYNRKLLENILPVHVAEH--------FLSREKHLDDLYHEQCDSVCILF----ASIP--- 1301
            :..|:|.|..|:  .||..:...        |::..:|:.|...|.|....||:    :|:|
Worm   509 LTFLRANNNSLV--ALPERIFYSQSLRSIFAFINEIEHIPDFGEENCLETLILYKNKLSSLPKHF 571

  Fly  1302 ----------NFSEFYVELEGNNEG-----VECLRLLNE--------IIADFDEL----LSEERF 1339
                      |.|..::||....:|     ::.||..|.        :|.:...|    ||..|.
Worm   572 FSILPRLRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNRL 636

  Fly  1340 RCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHS----------FN 1394
            ...:....:....:....|::|        .:|.:|| .|.|...::.:..||          .:
Worm   637 NSFDDSALSSLELLEDLNLSSN--------RLTRLAD-CLALLPCLQVLRAHSNQLVHVPEFRAS 692

  Fly  1395 NFRMRIGINIGPVVAGVIGACKP----QYDIWGNAVNVASRMDSTGLVDHIQVTQEMQ--QILEG 1453
            |....|.::...:..|.:....|    .:|:..|    :...|:....::.::..:|.  .|.||
Worm   693 NQLHTIDVSSNNISLGTLQFKAPPNLRHFDVTCN----SGDFDTENFPENAKMHSKMNTINISEG 753

  Fly  1454 R----GFELTCRGSVDVKGK-----------------GS----------MITYFLKGRRPIDAKE 1487
            .    ||::...||..:|.|                 ||          .:|.:||....:|.:.
Worm   754 SQNLFGFQIGVSGSRGMKNKQCIRQVRVENTFGFIDGGSNSYMSSSICRFMTSYLKENVSMDIRS 818

  Fly  1488 LELAKTEVEPPKTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTA 1552
            : |.:...|      |.:|.|:|.:.....:..|:..|..||.     ..|..|..|..::.:..
Worm   819 I-LLRCHCE------LGEEGERLGASVMIIRVHEKRLEIASTG-----TMSAAIARNQKLKMIIN 871

  Fly  1553 QRRKSLCRQHN-ISSSFGTTVSSSTGITPSISNSSSVVTIGALPAILRGGNPLSNANPNATDSCS 1616
            .|.:....::: |..:.| .|.....|...|.:|..:......|.:|
Worm   872 GRYEIDDDEYSRIREAHG-FVDEENRINGVIGSSRQIGHFSTFPVVL------------------ 917

  Fly  1617 ECGGASKSLATPTAPPRTLVADLKDEIARDEKIGLKDSIENLEI---LLKNNISLSDLSNKQQQN 1678
                       ||...|              .|.|.:.||.|.:   ::.|.:|:.||::....|
Worm   918 -----------PTHSYR--------------NIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNN 957

  Fly  1679 LRGETSSSTTTTLRKRDTIVSF----NVTETVTTTAAPFTSSSGSSNSSSQQK------------ 1727
                 .|......:.:|.:.|:    |....|.....|..:.:|.|.||::.:
Worm   958 -----RSPIVVAKKIQDQLQSYDYGGNSNILVLRRIKPQMTFNGFSTSSTKNQVTPDIAIPKIDE 1017

  Fly  1728 ---------------------------KRRSVTTIAASFTTSTTTRLLS-----NESQSSTQTAP 1760
                                       :.|:.:.......:||...:.|     |..||||.:..
Worm  1018 QLVLAVPALILPEYHPSPPVPPPIPAIRHRTPSPPPPPLPSSTPPPVSSEHEEINVRQSSTLSGG 1082

  Fly  1761 GTLE-----SGGSVPGQSSTENSSQDWQPRTASLEP 1791
            .||.     |..|........|.::|...::..|.|
Worm  1083 YTLSIDRFYSSSSTVSSRKQFNETRDLLSKSLKLSP 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	31/195 (16%)
		Guanylate_cyc	722..895	CDD:278633	35/209 (17%)
		DUF1053	<949..1005	CDD:283888	11/55 (20%)
		CYCc	1259..1455	CDD:214485	46/257 (18%)
		Guanylate_cyc	1285..1479	CDD:278633	49/274 (18%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	4/29 (14%)
		leucine-rich repeat	254..288	CDD:275380	9/34 (26%)
		PLN00113	283..>718	CDD:331614	103/577 (18%)
		leucine-rich repeat	289..311	CDD:275380	8/55 (15%)
		leucine-rich repeat	312..334	CDD:275380	8/47 (17%)
		leucine-rich repeat	335..357	CDD:275380	7/43 (16%)
		leucine-rich repeat	358..379	CDD:275380	5/27 (19%)
		leucine-rich repeat	380..440	CDD:275380	15/71 (21%)
		leucine-rich repeat	441..485	CDD:275380	9/59 (15%)
		leucine-rich repeat	486..508	CDD:275380	5/31 (16%)
		leucine-rich repeat	509..534	CDD:275380	6/26 (23%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		leucine-rich repeat	578..602	CDD:275380	5/23 (22%)
		leucine-rich repeat	603..625	CDD:275380	4/21 (19%)
		leucine-rich repeat	626..649	CDD:275380	4/22 (18%)
		leucine-rich repeat	650..672	CDD:275380	7/30 (23%)
		leucine-rich repeat	673..694	CDD:275380	2/20 (10%)
		PP2Cc	754..985	CDD:214625	51/291 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900