DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and gcy-33

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	957	Identity:	204/957 - (21%)
Similarity:	356/957 - (37%)	Gaps:	259/957 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   946 GFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYF 1010
            |:||               ||..:..|..|.::.          .||:.|....|.| ::....|
Worm    81 GYGD---------------LMNVMGRRFSDFIKG----------LDNIHEYFRFSYP-KLRAPSF 119

  Fly  1011 YCSL-----LVL----LGTSIMRLVVFQSSLLTLA-----LSTGALLL----LGFLVFLVACHKI 1057
            ||..     |:|    ..|..:..|:.|  |:.||     |..|..:|    .|...|:|.  ||
Worm   120 YCKSESEDGLILHYRSRRTGYLSYVIGQ--LVELARVFYQLDIGIQVLKKKEKGRFTFVVL--KI 180

  Fly  1058 NFQ--------------------LPSDIK----RFSLRIHSNRRISQLFA-------FASVALIV 1091
            :|.                    ||.|.|    .|...|..|:::..|.|       ..::..::
Worm   181 SFDNVGLGQDLKLKERVKNLNEYLPVDTKSFLQMFPFHIAFNKKLEILMAGQGLLNLMPNIQGLL 245

  Fly  1092 LTTL--------------LAMFQESGRQMELLQRRRFWLDVNGSISLND-TELNTKMYDAEEPDC 1141
            :|.:              :.:.|....|:|.|.......:.|.::.:|| ||....:......|.
Worm   246 MTDVFDLQRPCIKFTAEGIMVHQNCVFQIESLHPVVKQTEENITVQINDITEDKVSLEKKTVMDN 310

  Fly  1142 DFYLAYNTFLLL-----------TLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRS- 1194
            ::.|....::.|           |.|.:.:|.. ..|..:.|:       |.|:    |.:..|
Worm   311 EYGLESLPYVTLRGPITVLKSSETFLLLATCVV-DTLDTMFKM-------GLYL----NDFGESD 363

  Fly  1195 --REMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQA 1257
              ||:......:...|:.::::            ...::|.           .||...::...:.
Worm   364 CNREIIMATIQKSDTLKTMLEN------------EKRRSEV-----------LTEMTREISEAKK 405

  Fly  1258 YNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRL 1322
            ..|.||..::|..||:..: |...:|  :.|..:.|.|.|..:.:||:..:.:    |..|.:.|
Worm   406 TARTLLTQMMPYEVAQTMM-RSGSVD--HCEAFECVSIGFIRVCDFSKISLFI----EAFEVVNL 463

  Fly  1323 LNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEE 1387
            ||.|.:..|.::....   :.|:::.|.:||.::|     |...:......::|..|::...|:.
Worm   464 LNTIYSHLDSIVDTHG---VYKVETIGESYMISAG-----CPYRDDYDAEMVSDCCLEMVSHIKS 520

  Fly  1388 VNMHSFNNFR---MRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVD-HIQVTQEMQ 1448
            ....|.:..:   ::.||..||||.||:|...|:|.::|:.||.||||:|:.... .||:.|..:
Worm   521 FEYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTK 585

  Fly  1449 QILEGR---GFELTCRGSVDVKGKGSMITYFL---KGRR------PI---------DAKELELAK 1492
            ..:|.:   .|.:..:|:|.|||||.|..|.:   |||.      |:         :|:||....
Worm   586 DRVEKQASGAFRIKPKGNVFVKGKGDMRVYEIEKKKGRARYKKSDPLRKKMVAEKKEAEELLDED 650

  Fly  1493 TEVEPPKTLTLAKEPEKLDS-----GTATEKQREQVKEQGST-EQEDDLLPSPDIDMN------- 1544
            .|......|:.....|.:||     |:.:..|.|..|....| |.......:.|::|.
Worm   651 NEGHRSSALSRMSLGESIDSSSSRRGSLSGSQLELNKTIAQTIELTSKASAALDLNMQDENNRPP 715

  Fly  1545 ----SNMQNLTAQRR-------KSLCRQHNISSSFGTTVSSSTGITPSISNSSSVVTIGALPAIL 1598
                |:.|::...|:       .|.....:::.|...|...|.|.||..::|.           |
Worm   716 TWSASHSQDIRKPRKTESKITLNSRLSSSDLAVSRVETSKDSDGETPRPTSSE-----------L 769

  Fly  1599 RGGNPLSNANPNATDSCSECGGASKSLATPTAPPRTLVADLKDEIARDEKIGLKDSIENLEILL- 1662
            :..|.:                ..::||......||    .|:|..:.|::| :|.:.....||
Worm   770 KEVNRI----------------REEALAQEKEEERT----TKEENQKIEEVG-EDHVSEATSLLD 813

  Fly  1663 ------KNNISLS-----DLSNKQQQNLRGETSSS-----TTTTLRKRDTIVSF-NVTETVTTTA 1710
                  .||||.|     .:.::.:.:|...|.|.     :...|.|.|:..|. ::.|..|.:|
Worm   814 SEVSHGDNNISFSQMPSDSIPHEDRTSLPSATPSEIGDAISKKKLEKEDSNSSMSSLDERTTVSA 878

  Fly  1711 APFTSSSGSSNSSSQQKKRRSVTTIAASFTTSTTTRLLSNESQSSTQ 1757
            .|.|:....:....:::|:||  ::|.|..||::....|..|:..|:
Worm   879 KPTTTRRLLNQKDLEKEKKRS--SMAGSSVTSSSAHSHSIRSKKDTR 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888	10/55 (18%)
		CYCc	1259..1455	CDD:214485	54/202 (27%)
		Guanylate_cyc	1285..1479	CDD:278633	56/203 (28%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902	25/110 (23%)
		HNOBA	204..423	CDD:369471	43/253 (17%)
		CYCc	402..598	CDD:214485	55/210 (26%)
		COG5134	<595..744	CDD:227463	34/148 (23%)
		TDA11	<710..>898	CDD:293689	42/219 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910