DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and daf-11

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_505960.3	Gene:	daf-11 / 179605	WormBaseID:	WBGene00000907	Length:	1077	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	107/369 - (28%)
Similarity:	170/369 - (46%)	Gaps:	59/369 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1206 ALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATE-EKEDMEHLQAYNRKLLENILPV 1269
            ||.|.|||::...:..|..:...:.|..|..|:...|.:..| |||     |....:||..:||.
Worm   685 ALARKIIDTVLKMSGSLVDLMIKNLTAYTQGLNETVKNRTAELEKE-----QEKGDQLLMELLPK 744

  Fly  1270 HVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELL 1334
            .||.. |.....:|...:|   :..||::.|..|:    .|...::.:|.:.||:.:...||.::
Worm   745 SVAND-LKNGIAVDPKVYE---NATILYSDIVGFT----SLCSQSQPMEVVTLLSGMYQRFDLII 801

  Fly  1335 SEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNM-HSFNNF-R 1397
            |::..   .|:::.|..|..|:||..    .:...||.::...||...|.:....: |....| .
Worm   802 SQQGG---YKMETIGDAYCVAAGLPV----VMEKDHVKSICMIALLQRDCLHHFEIPHRPGTFLN 859

  Fly  1398 MRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTC-- 1460
            .|.|.|.|||.|||||...|:|..:|.||.:||:|:|:|:.|.||:|...||:||....:..|
Worm   860 CRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQMTLASQQLLEENFPQFVCSN 924

  Fly  1461 RGSVDVKGKGSMITYFLKGRRPIDA------------------------KELELAKTEVEPPKTL 1501
            ||...::|.|.::||:|:|   ::|                        .||..|.|.::|...:
Worm   925 RGGRTIEGIGRILTYWLEG---VNAGEQVKVVEFQNDLNDELSRIMKKDGELLAAATALKPKDKM 986

  Fly  1502 TLAKEPEKLDSGTATEK-QREQVKEQGSTEQEDDLLPSPDIDMN 1544
            |||||....:.....|: ||:|..::...|.|:      :|:||
Worm   987 TLAKEKVIAERKNEEERLQRQQTLQEALEEHEE------EIEMN 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485	62/197 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	62/197 (31%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141
		PKc_like	447..695	CDD:304357	6/9 (67%)
		HNOBA	<714..750	CDD:285003	13/41 (32%)
		CYCc	729..922	CDD:214485	65/212 (31%)
		Guanylate_cyc	756..943	CDD:278633	63/200 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810