DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and acy-4

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	998	Identity:	380/998 - (38%)
Similarity:	556/998 - (55%)	Gaps:	163/998 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 LVFLIVMLICGIVYAF------LLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSF 583
            |:..|:.|:..|:..|      |:||.|          ::|.||:....::..:|:|
Worm   122 LILCILTLVISILSFFHAKRTELVCIAS----------IISCVIISACTSMRTSVTY-------- 168

  Fly   584 NGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVAL 648
                   :||:.||::||:.....:.....|:.:..:    :..:.|..|   .::.:|..::.:
Worm   169 -------LLIFSTYSLLPMSFMLMIFSTFALTFLVAF----IGVLMDYNV---GFDIILTRVMMV 219

  Fly   649 LLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQ 713
            :|.|:.|...::|.|..|||.|.|||:|:::|:...:|..:||::||:|||:::|.|:|.|:...
Worm   220 ILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQET 284

  Fly   714 PRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLL 778
            ..:..||||||:::|::|||||||||||:|:.:...::||.:|||||||||::|:.|.|:|||:|
Worm   285 HEERMFHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKIL 349

  Fly   779 GDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQ 843
            |||||||.|:||.:.:||...||||.|||:||.||||:..||||||||||||:.|||||||.|||
Worm   350 GDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQ 414

  Fly   844 FDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGD 908
            ||||||||||||.|||||:.||||||..|...|.|.|.:|.|.|..|:.:|:..:|:|:|:|...
Worm   415 FDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYILEEGNGGSRSKFLEKEKIKTWLVVDRS 479

  Fly   909 --------------IYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPE- 958
                          :..|.|.:|       .|||:.|:.|..|..:       |.|:.:....|
Worm   480 PDYDNICQEATNHPVMVPWKSTR-------GISKQERLTGMSTRTR-------GASTRNGLSEEE 530

  Fly   959 ---DEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLER-----KYASEPDRM--------LC 1007
               :.|:.:|.:.|.|...::.:..||::..|.:|...:|.     ||...|.::        :|
Worm   531 VLVENVDSHLRQGIQAIHQENWKTMHCKNWSLKYKQVRVENKFVRLKYKDIPFQVTLYVAIVAIC 595

  Fly  1008 VYFYCSLLVLLGTS-IMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLR 1071
            :.....|:.|:..| :.::.:..:|::...| |.||:....||.||
Worm   596 IGIKFGLMNLVSFSFVPQMFIVLTSVMIFIL-TRALIKHARLVSLV------------------- 640

  Fly  1072 IHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDA 1136
                  |..||...|:.:::   |:.|::.           :|..||......|.|
Worm   641 ------IGVLFILLSIQIVI---LMGMYES-----------KFTCDVEKCFKNNYT--------- 676

  Fly  1137 EEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRI--LLKLLLLLLASGSYMACSSNLYSRSREMSQ 1199
                 ||   :..|.:.||      ||..:|.:  :.|||:.::...|:....:....|..:.
Worm   677 -----DF---FEIFEICTL------ATCVILSVDFMTKLLMSMIYFSSFTVLITAKLIRINQY-- 725

  Fly  1200 ELANEEALL-RYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLL 1263
                 |||| .|....:.....:|.::|.:.::|...|.||||||||.:|:..|:.....||.:|
Worm   726 -----EALLSTYANFCVLSCLTLLLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVL 785

  Fly  1264 ENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIA 1328
            |||||.|||:||:.....:..||||..|:.||:||::..|.:||:|.:||||||||||||||||:
Worm   786 ENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIIS 850

  Fly  1329 DFDELLSE----ERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVN 1389
            |||::|.:    |.|:.|||||:...|||.||||....|.  :.|||.|:|.:|.:|..|:|..|
Worm   851 DFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECG--DNSHVEAIALFARELLVKLESTN 913

  Fly  1390 MHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGR 1454
            :||||||.:|||||:|||||||||:.||.||||||:|||||||||.|:...||||:|::.|||..
Worm   914 IHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPL 978

  Fly  1455 GFELTCRGSVDVKGKGSMITYFL 1477
            |:...|||.::|||||.|.|:||
Worm   979 GYNFECRGQINVKGKGMMETFFL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	50/200 (25%)
		CYCc	686..881	CDD:214485	122/194 (63%)
		Guanylate_cyc	722..895	CDD:278633	112/172 (65%)
		DUF1053	<949..1005	CDD:283888	14/64 (22%)
		CYCc	1259..1455	CDD:214485	117/199 (59%)
		Guanylate_cyc	1285..1479	CDD:278633	117/197 (59%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	50/200 (25%)
		CYCc	260..451	CDD:214485	121/190 (64%)
		Guanylate_cyc	293..448	CDD:278633	105/154 (68%)
		CYCc	778..984	CDD:214485	118/207 (57%)
		Guanylate_cyc	807..1003	CDD:278633	117/197 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1293
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11213
Inparanoid	1	1.050	605	1.000	Inparanoid score	I502
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002306
OrthoInspector	1	1.000	-	-		oto20571
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4931
SonicParanoid	1	1.000	-	-		X1998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.890