DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and gcy-18

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	1011	Identity:	186/1011 - (18%)
Similarity:	322/1011 - (31%)	Gaps:	398/1011 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 STNSSSTC------HSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRL 236
            :||:.||.      ...::::...|.:.:.....|.:||..|:||..|..|...
Worm   192 ATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNSGQLGDLAANA----------- 245

  Fly   237 NRIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTS 301
             |||  :|.....|.|..|.:...|.:|||.:...:|:..|.:....|        |..:.....
Worm   246 -RII--ICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDL--------TPWIGADGE 299

  Fly   302 LLLEISE-----------IGLDANATVGNLTTATMKPPTLASSDQMTR-------GSSIPLLALA 348
            :|..:.:           .|.| ::.|.:......|.....|...:|.       ..|:.|.|||
Worm   300 MLQRVKDHYANAIIVDDVNGFD-DSVVSSFVEKIEKHGMQKSDIDVTNINGYLHLFDSLKLYALA 363

  Fly   349 SNGSWAGNGAVGGELKSAHNHNIADFEADH-----NGQLVWRRQKRKHYRRLHKHRYKHKSHQQH 408
                          ::...|      |.|:     |||.:|.|.:|..:..:    ....|.:::
Worm   364 --------------IRKVLN------ETDNEAYVTNGQFIWNRMRRMKFEGV----VSRSSSEEN 404

  Fly   409 RTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTV----------------------- 450
            :            ||     |.|.|.|:.|.|  |.|.:::.
Worm   405 K------------DA-----GAIGTVLMDDVA--DRAPIFSAFYISPNRDKVMKMVNMESELISN 450

  Fly   451 -----------------------ASDD-----DDDVDGGR----------SAGS----------- 466
                                   .|:|     |:.:.|.|          |.||
Worm   451 CDGLKNKSGCFQLKINDIKSGFWPSEDGSMPLDEPICGYRGQRCSYLLEISVGSLIILLILISVV 515

  Fly   467 ----------KHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLG------------- 508
                      |.:...|....::.:...:.::|.:..|...|.|..|:...|
Worm   516 FFFLFRYCENKQLEKMPWRIFHDDLQFIDEEQVKSMMSVGSVTTKLSNIQTGQKQHAIIGVNTHT 580

  Fly   509 ----YGQLIPLILMQVDESVLV-----------------------FLIVMLICGIVYAFLLCILS 546
                |.|..|:..::.|..:|.                       .|::...|           |
Worm   581 TYHRYKQRRPIKFIKEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFC-----------S 634

  Fly   547 KPAMNEIFL---VLVSYVILGTFLA-IEVAVSYAMQPSKSFNGSA---CCIV------------- 591
            :..:.:|..   |::.....|.|:. |.:.:.|.......::||.   ||::
Worm   635 RGTIQDIIYNANVVLDEKFHGAFVRDITLGLEYLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGI 699

  Fly   592 --------------------------------LIYMTYTMLPLR------------LREALI--- 609
                                            :|||...:|..|            ::::::
Worm   700 ANPLERWEKQGAIEIAAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSMLRRQ 764

  Fly   610 -------GGILLSVVHLYTCLRLNAMQDEAVEM-----------------IH----------WEE 640
                   |.::..::......|.|....|.|:.                 :|          |.|
Worm   765 AGDIYSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTVSPEIQNQMGLHPDLNALLRDCWSE 829

  Fly   641 -----------------LLCT---LVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQR 685
                             :|.|   ||..::..:.....:..|..|:|...:|     ||.:|.
Worm   830 NPEIRPSIRRVRLNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLE-----EANIRA-- 887

  Fly   686 ENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAE 750
                 ::||..:||.:||.|:|...:..|      |:|    .:.:|||:||.|||::....|..
Worm   888 -----DQLLTQLLPAYVANELKMGRSVAP------KLY----SSATILFSDIVGFTTICSGSTPL 937

  Fly   751 ELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRP-DHAHCAVEMGLDMIDAIALVR 814
            |:|.:||.|:..||.....:...:::.:||.|..|||:||... :|:.......|||       |
Worm   938 EVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDM-------R 995

  Fly   815 EVM---------AVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITK 870
            :.:         ...|..|.|.|||.|..||:||...::.::.:.|.:::.|||.|.||.:.:::
Worm   996 QYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSE 1060

  Fly   871 ETLKCLDGDY---------EVEV-GKGNERNSYLKD 896
            |....:...:         ||:| |||..|..:|:|
Worm  1061 EAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLED 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	47/340 (14%)
		CYCc	686..881	CDD:214485	59/213 (28%)
		Guanylate_cyc	722..895	CDD:278633	56/192 (29%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141	60/321 (19%)
		ANF_receptor	87..395	CDD:279440	49/245 (20%)
		PKc_like	549..846	CDD:304357	36/307 (12%)
		HNOBA	<857..903	CDD:285003	13/57 (23%)
		CYCc	882..1073	CDD:214485	62/214 (29%)
		Guanylate_cyc	909..1095	CDD:278633	58/202 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810