DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gcy-8

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_501324.2	Gene:	gcy-8 / 177584	WormBaseID:	WBGene00001535	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	943	Identity:	185/943 - (19%)
Similarity:	320/943 - (33%)	Gaps:	316/943 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   787 GLPEPRPDHAHCAVEMGLDMIDAIAL----VREVMAVNVNMRVGIHTGRVHCGVLGLVKWQ---- 843
            ||.|...|.|:  :...|.:.||:.|    .|:|:.         .||:....:.|.:.||
Worm   352 GLTEADVDIAN--IYGYLYLFDALKLYAIAARKVLN---------ETGKAENLLNGRMMWQNMRK 405

  Fly   844 ---------FDVWSNDVTLANHME-------------SGGIPGRVHITKETLKCLD------GDY 880
                     ..:.|..|::.:..|             |..:...||:....|...|      |.|
Worm   406 LKFVGMVGASGIASGQVSMDDRAERAPLYRGFFVSPNSDSVLPMVHMEPTMLDNCDGIANKSGCY 470

  Fly   881 EVEV----------------------GKGNERNSYLKDHQIETYLIV------------------ 905
            |:.|                      |..|||..|       |.:|:
Worm   471 EIVVTDIMRDFWPSVDRKMPKDEPDCGYRNERCDY-------TLIIIGAALILLFIVAAVSAFFA 528

  Fly   906 ------------PGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPE 958
                        |..|||...:..:..|:..       |:..|:.:...|...:|..:.:.....
Worm   529 QKILEKRALDKLPFRIYRDDLQFIDEEQLKS-------MLSLGSTRTKMSNMNYGSRNHAIVGTN 586

  Fly   959 DEV--NEYLMRAIDARSIDHLRAEHCQSLLLCFK----DNV---LERKYASEPDRMLCVYFYCSL 1014
            ...  ::|:.|    |.|...||:  ::|:...|    ||:   |...: :|.:.||.|:.:||
Worm   587 THAIYHKYVQR----RPIVFNRAD--KTLIQLMKAAVHDNINPFLGMVW-NEREEMLLVWKFCS- 643

  Fly  1015 LVLLGTSIMRLVVFQSSLLTLALSTGALL--LLGFLVFLVACH---------------------- 1055
               .||  ::.:::..|:.......||.:  :|..|.:|.|..
Worm   644 ---RGT--LQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKL 703

  Fly  1056 ------------------------------------KINFQLPSDIKR------------FSLRI 1072
                                                .|.::.|..:|.            :..:.
Worm   704 TDYGIADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPEMLKNREKNRVRRVDQDWMRQT 768

  Fly  1073 HSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAE 1137
            .:.|::..::||..|...::...|. |.|...|.||::    ||. :||..:..|....|:.:.:
Worm   769 QTRRQLGDVYAFGLVMYEIIFRALP-FPEGTNQSELVE----WLR-DGSKVVKPTIPQNKVLNMD 827

  Fly  1138 EPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELA 1202
                           |:.|......|...:|..|:.:.|.:.  :|:....:|..:...|.::.|
Worm   828 ---------------LSALIQDCWNTTPEMRPSLRRIKLNVE--TYLNIKGSLVDQMTRMMEQYA 875

  Fly  1203 NEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENIL 1267
            |.  |.:.:.:...:.            .||..|.|                      :||..:|
Worm   876 NN--LEKLVAERTGML------------EEANQRAD----------------------RLLSQLL 904

  Fly  1268 PVHVAEHF-LSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFD 1331
            |.:||... |.|     .:..:...|..:||:.|..|:    |:..|...:|.:.:||.|...||
Worm   905 PAYVANELKLGR-----PVPPKTFTSSTVLFSDIVGFT----EMCQNASPLEVVAVLNGIFDGFD 960

  Fly  1332 ELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEE--VNMHSFN 1394
            :.::.   :...|:::.|..||..||:......|    |:..:|..||.:...:.|  |......
Worm   961 QFIAR---KDAYKVETIGDAYMVVSGVPEENGHR----HINEIASIALDVHKFLSEFIVPHKRDT 1018

  Fly  1395 NFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELT 1459
            ..:.|:|.:.|||.|.|:|...|:|.::|:.||:||||:|.......|:::..:.:|.....:..
Worm  1019 KVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYI 1083

  Fly  1460 C--RGSVDVKGKGSMITYFLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLDSGTATEKQREQ 1522
            |  ||.:.:||||..:||:|.|           .|:|........||  |....:||
Worm  1084 CEQRGEIPIKGKGLCMTYWLMG-----------TKSEGSGRSGAYLA--PSMKSAGT-------- 1127

  Fly  1523 VKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQRR 1555
                |.|    .:|.:...|.:.|::|.|..:|
Worm  1128 ----GFT----GMLGNSANDYSLNLKNPTGLQR 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	25/129 (19%)
		Guanylate_cyc	722..895	CDD:278633	33/165 (20%)
		DUF1053	<949..1005	CDD:283888	12/64 (19%)
		CYCc	1259..1455	CDD:214485	54/198 (27%)
		Guanylate_cyc	1285..1479	CDD:278633	56/197 (28%)
gcy-8	NP_501324.2	ANF_receptor	87..442	CDD:279440	19/100 (19%)
		Periplasmic_Binding_Protein_Type_1	94..434	CDD:299141	19/92 (21%)
		PKc_like	558..850	CDD:304357	54/332 (16%)
		HNOBA	<866..912	CDD:285003	14/81 (17%)
		CYCc	891..1084	CDD:214485	58/230 (25%)
		Guanylate_cyc	918..1105	CDD:278633	56/197 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810