DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and acy-1

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	1250	Identity:	359/1250 - (28%)
Similarity:	508/1250 - (40%)	Gaps:	377/1250 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 LILMQVDESVLVFLIVML-ICGIV---YAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAV-- 573
            |.|...|.:.:...||.| :|.|:   :||..|    .|..:.|.:..|:  |.|||...|.:
Worm    82 LYLALFDRTFIQHWIVSLCLCAIIFAMFAFTAC----AAQYQRFYMPTSF--LCTFLICLVTLLI 140

  Fly   574 ------SYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEA 632
                  :..|.|..|...|...::||   ||::||.|...::.||:.|:  |:..|..|.:..|.
Worm   141 FSAENQAAFMTPVASLATSFQVVLLI---YTVIPLPLYLCILIGIIYSI--LFEILNKNKIGLEE 200

  Fly   633 VEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSV 697
            ...|       .||.....:|.||:.....:..|||.|::..|.:.||...:.|.|.::.::.||
Worm   201 AGYI-------KLVLHAGVHLLGVHLFILTQVRQRKTFLKVGQSMLARKDLELETQFKDHMIQSV 258

  Fly   698 LPRHVAMEMKDDI------------------AGQ---------PRDTQFHKIYIQRHENVSILFA 735
            :|:.||.|:..|.                  |.|         |...:|....:....|||||||
Worm   259 MPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLAKMVPEYRKFRPFTMNLMTNVSILFA 323

  Fly   736 DICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAV 800
            ||.|||.:|...:|:|||.|||:||.|||.|.......:|..||||||||:|.|||..|||...|
Worm   324 DIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAGCPEPCDDHACRTV 388

  Fly   801 EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGR 865
            |||||||.||..........||||||||||:|.||::|..:::|||:||||||||.|||.|:.||
Worm   389 EMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGR 453

  Fly   866 VHITKETLKCLDGDYEVEVG-----------KGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNR 919
            ||:::.|.|.|.|.||:|.|           :|.||.  :|...::|:.|          |.|
Worm   454 VHVSEATAKLLKGLYEIEEGPDYDGPLRMQVQGTERR--VKPESMKTFFI----------KGR-- 504

  Fly   920 LQVNGNISKELRMM-------GHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHL 977
              :|..:.:|:..:       ...:::|.|.|..:.:     |...:..|.|.|||........|
Worm   505 --INDGVEEEVMQVQEVESLHSQKSSKKSTLKQKWAE-----KLKMNHTNSYPMRAAAREGGGSL 562

  Fly   978 R---AEHCQSLLLCFKDN----VLE--RKYASEPDRMLCVYFYCSLLVLLGT------------- 1020
            |   ||..:|..|..|::    ::|  ||.||              |..|.|
Worm   563 RIKLAERNRSTQLLPKESNSICIMEDNRKSAS--------------LQALATNNFNGSNTDTNNT 613

  Fly  1021 --------SIMRLVV----------FQSSLLTLALSTG--ALLLLGFLVFLVACHKINFQLPSDI 1065
                    |:.:..|          .:||.|.|:|..|  .|..:|.|...::.|    ...:.:
Worm   614 YSERGVAGSVSKKSVAGSESNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAISHH----HNAASL 674

  Fly  1066 KRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELN 1130
            .||....:.::|::.:....               |.|..      :.||   |...|||...|.
Worm   675 TRFDTDNNFDQRLAMVIGQG---------------EGGFD------KGFW---NHHDSLNKWTLR 715

  Fly  1131 TKMYDAEE-------PDCDFY-------------------------------------------- 1144
            ....|.||       ...:.|
Worm   716 FNEKDVEEEYRAHFVDSSERYTASKKGHVERHKDLMEQGGEKDGITGSTVNKYRYSGVFIDIIVA 780

  Fly  1145 ----------------------LAYNTF----LLLTLL----------SMMSCATYQVLRILLKL 1173
                                  :||..|    |:||::          ....||...:.|.|:.|
Worm   781 TLIFVISGAVAIMSVRPFPLSLIAYFPFAAAILILTIVLIGLPLLARKKSFQCANQWMPRHLIGL 845

  Fly  1174 LLLLLASG-------------------------SYMA---------------------------- 1185
            ||:.|..|                         ||:.
Worm   846 LLIFLPIGVAICIMPLCQSGDCANVILNYRLAFSYVTILAIFAHCNFSQLAAWPKTTAAVFIGLL 910

  Fly  1186 -------CSSNLYSRSREMSQELANEEAL--------LRYII---------------DSIFLFAF 1220
                   |..||.....|  |:..|..|:        |.|.|               ..:|::..
Worm   911 HIAGVFYCEFNLKHLVEE--QDTCNVTAIMIPPIRKGLNYTIALNSTSARTLSQDFGSPLFIWEL 973

  Fly  1221 MLALI-------FHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSR 1278
            :|.:|       |.::|.|..:|:.|...:||..:.|.|:.::.....||.|::|.|..|...:
Worm   974 LLDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRDQADWLLNNVIPAHAVESLKT- 1037

  Fly  1279 EKHLDDLYHEQCDSVCILFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDELLSEERFRCI 1342
                |..|.|..::|.:|||||.|:::.|.| .||   |.|.||:|||:|.||||||....|..|
Worm  1038 ----DTKYSENHETVGVLFASITNWNDMYEENFEG---GREFLRVLNEVIGDFDELLDRPDFTHI 1095

  Fly  1343 EKIKSTGATYMAASGLTANTCDRVNF----SHVTAMADYALQLFDKIEEVNMHSFN-NFRMRIGI 1402
            ||||:.|..|||||||  |...:.|.    .|:..|.|:||.:...:...|....| :|..::|:
Worm  1096 EKIKTIGPAYMAASGL--NPERKKNMLHPKEHLYQMVDFALAVQHVLSVFNEDLLNFDFVCKLGL 1158

  Fly  1403 NIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVK 1467
            |||||.|||||..|..|||||:.||:||||.|||:::.|||:|..::.|..| :|...|..::||
Worm  1159 NIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDR-YEFEFRDHIEVK 1222

  Fly  1468 G-KGSMITYFLKGRR 1481
            | .|.|.||.|.||:
Worm  1223 GIDGGMDTYLLVGRK 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	59/235 (25%)
		CYCc	686..881	CDD:214485	102/221 (46%)
		Guanylate_cyc	722..895	CDD:278633	96/183 (52%)
		DUF1053	<949..1005	CDD:283888	18/64 (28%)
		CYCc	1259..1455	CDD:214485	89/201 (44%)
		Guanylate_cyc	1285..1479	CDD:278633	93/200 (47%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	29/109 (27%)
		CYCc	297..469	CDD:214485	91/171 (53%)
		Guanylate_cyc	317..503	CDD:278633	99/197 (50%)
		SDF	<773..982	CDD:294387	30/210 (14%)
		CYCc	1016..1215	CDD:214485	91/209 (44%)
		Guanylate_cyc	1041..1235	CDD:278633	93/199 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810