Protein Alignment CG43373 and acy-3

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1350
• Identity: 283/1350 - (20%)
• Similarity: 523/1350 - (38%)
• Gaps: 334/1350 - (24%)

  Fly   492 TSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLV 556
            ||.:|.:.|....|  |:..|...:::.:....::|.|:                :||....|.:
 Worm    31 TSGSAFLRTLGHIP--GFYALWTAVILLLSTVTIIFHIL----------------RPARIAAFQI 77

  Fly   557 LVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYT 621
            |...|:|       :.|::|:...:|...:   ::.::..||...|.....|....|:|:|.  |
 Worm    78 LAGIVLL-------LDVAFALPGYESLFPA---LLAVFSLYTFFSLPFYAILATSTLISIVQ--T 130

  Fly   622 CLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRE 686
            |..|     ..||.:|..|||..:|..:..|.||:|.....::..|.||:..|...||....:.:
 Worm   131 CSFL-----LFVEPLHTNELLAIIVVHIWTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQ 190

  Fly   687 NQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHK--IYIQRHENVSILFADICGFTSLSDQCTA 749
            :.:..:||.|.||.|:..:.:..|.       .:|  :|.:.:..||:.:..:.||.|:..||::
 Worm   191 SNRLNKLLSSFLPYHLINQARHQIT-------LYKPHLYNETYSQVSVAYGRLVGFESVLAQCSS 248

  Fly   750 EELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVR 814
            .:..|:|.||.:|.:||||.:.|.|:...|....|  .:|.....||.......:::...|...|
 Worm   249 IDAARVLKELDSRIERLAASNGCTRVASEGITAVC--SIPGIDSQHATKLCRFSMELETLINSFR 311

  Fly   815 EVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGD 879
            :....:|::.:||.:|.|..||:|:.||.:||..:....|..|:|......|:::.||.:.|...
 Worm   312 DATGADVSVCIGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNETRRFLGST 376

  Fly   880 YEVEVGK---GNERNSYLKDHQI------ETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGH 935
            .|.|:.|   |.:...:|...::      .:.:.||..:.|.       ||....::..|:.||
 Worm   377 GEFELEKCPIGWKLYGHLPSPELFPVNKRFSLVTVPQAVNRV-------LQSIVAMNPTLKTMG- 433

  Fly   936 GTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYAS 1000
                  |:|...|:.|:...|            :..:.::|  :....:|...|::..||.:|..
 Worm   434 ------TNKKRKGEKSQEKFD------------MQKKKVEH--STIISTLSQRFRNPGLEAEYHK 478

  Fly  1001 EPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDI 1065
            |.|.........|:..|:...|..::|....:.:|||..|||.::.|::.::   .|::
 Worm   479 ETDHWFIPSLAISIFFLVVYGIYHMLVMPRLITSLALIVGALTVMFFILLML---YIDY------ 534

  Fly  1066 KRFSLRIHS-NRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTEL 1129
                  .|: ::.|::..|..:|::|::..:|                 |...:..:.|..
 Worm   535 ------FHTFSQFITRTSAGHAVSIILIIVIL-----------------FVCGIVNTFSCP---- 572

  Fly  1130 NTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLR---ILLKLLLLLLASGSYMACSSNLY 1191
                 ....||......::|:    ..:|.:..|...:|   :.|.:||::    |.:.....:|
 Worm   573 -----QPNAPDVCQKAHFSTY----SFAMWTITTAVFVRFPSVYLAILLII----SLLTYGLQIY 624

  Fly  1192 -SRSREMS-QELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEH 1254
             :|..|.. :|...|..|      |.||.:.:..:..||.:.|...||||:..::..||....:.
 Worm   625 VTRPDEFGPREFMTELDL------SCFLISLVSMVFLHSRRCERLLRLDFLAVVKGIEETSMKDK 683

  Fly  1255 LQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVEC 1319
            |...|.::|.|::|.|||...:.:   ..|::|....||.|.:.::..|     :||| ..|:..
 Worm   684 LINLNNQMLLNLVPAHVAPGVIQK---AGDVWHHSHQSVGIAYIAVSGF-----DLEG-EAGING 739

  Fly  1320 LRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVN------------FSH-V 1371
               ||.:.:.||:.::  .::.:||:||....|:.|.||..:....||            .:| :
 Worm   740 ---LNYVFSHFDQAIA--NYKGVEKVKSANRFYIVAVGLLPDAAQNVNETPWTIGELMSTLAHFI 799

  Fly  1372 TAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTG 1436
            .:::.:|::             |.|.::||::.|..:|.|....:|:|:|:|..::.:..:....
 Worm   800 ISISQFAME-------------NEFHVQIGVDCGSTLAFVANTDQPRYEIFGETLDRSRTLMQAA 851

  Fly  1437 LVDHIQVTQEMQQILEGR----------------GFELTCRG----SVDV----------KGKGS 1471
            ..|...|::|:...|..|                .:||. .|    |||:          ..:|.
 Worm   852 GHDTTLVSEEVFLALRPRPLRFSSQPVKVAMNLNAYELV-TGLRDVSVDIPTMPREEQERHTQGM 915

  Fly  1472 MITYFLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDD-- 1534
            :...|....|..|.:..|:|.:...     :.:.|...:|....|:...|.:..:.:..::..
 Worm   916 VEAQFANQSRMYDTQTSEMASSMAS-----SFSSELRSIDGDAETDSDLEWITPETALMKDPQPQ 975

  Fly  1535 -----LLPSPDID-----MNSNMQNLTAQRRKSLCRQHNISSSFGTTVSSSTGITPSISNSSSVV 1589
                 :|.:.|.|     ::.|::.::|::.   .|...|.|
 Worm   976 RSHRFVLKNSDYDPYREPVHRNIRAMSAEQD---YRNRRIQS----------------------- 1014

  Fly  1590 TIGALPAILRGGNPLSNANPNATDSCSECGGASKSLATPTAPPRTLVADLKDEIARDEKIGLKDS 1654
                       |:.:|:|         ||||           |.|..|:.::...|..:...|:|
 Worm  1015 -----------GSDMSDA---------ECGG-----------PSTSRANSRNSYRRGWRPSSKNS 1048

  Fly  1655 IENLEILLKNNISLSDLS-----------NK-----QQQNLRGE--------------------- 1682
            :.|...|.:...|.::.|           |:     |:.|..|:
 Worm  1049 LRNGFGLFRKGHSDNEQSVDGIDKIEAAANRVDRMIQELNAFGDFAEIKPLEYQPFPANFGSVKS 1113

  Fly  1683 ---TSSSTTTTLRKRDTIVSFNVTETVTTTAAPFTSSSGSSNSSSQQKKR 1729
               ..||...|  :.|...|..|...|.:.|   .|.|...||.|:||:|
 Worm  1114 IHRAMSSACHT--EYDNAESDAVISDVESNA---NSISQLRNSKSRQKRR 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	45/196 (23%)
		CYCc	686..881	CDD:214485	53/196 (27%)
		Guanylate_cyc	722..895	CDD:278633	49/175 (28%)
		DUF1053	<949..1005	CDD:283888	10/55 (18%)
		CYCc	1259..1455	CDD:214485	49/224 (22%)
		Guanylate_cyc	1285..1479	CDD:278633	49/236 (21%)
acy-3	NP_497765.4	TctB	26..137	CDD:284693	28/140 (20%)
		CYCc	195..378	CDD:214485	53/191 (28%)
		Nucleotidyl_cyc_III	221..382	CDD:299850	47/162 (29%)
		CYCc	696..873	CDD:214485	46/203 (23%)
		Nucleotidyl_cyc_III	711..880	CDD:299850	41/192 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810