DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gcy-29

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001364597.1	Gene:	gcy-29 / 175116	WormBaseID:	WBGene00007314	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	259	Identity:	79/259 - (30%)
Similarity:	132/259 - (50%)	Gaps:	42/259 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 TRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADI 737
            |:...||.||.       ||||..:||:|||:|:|   ||:   |...|:|    ::.:::|:||
Worm   835 TKLAEEANLRA-------ERLLFQLLPKHVAIELK---AGR---TVAPKMY----DSATVMFSDI 882

  Fly   738 CGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEM 802
            .|||.|....|..|:|.|||:|::.||.:.::|.|.:::.:||.|..|||:|          :|.
Worm   883 VGFTKLCSASTPIEVVNLLNKLYSEFDTVISKHDCYKVETIGDAYMVVSGIP----------IEN 937

  Fly   803 G---LDMIDAIAL-VREVMAV---------NVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLA 854
            |   :..|.|:.| :.:::.|         .:.:|:|..:|:|...|:||...::.::...|.:|
Worm   938 GQRHVANISAVTLGIMDLLKVFEVPHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIA 1002

  Fly   855 NHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRN 918
            ..|||.|..|||.||:.:...|:.:|...:.:....|..:|.....||.:...|  ..:.|.:|
Worm  1003 AVMESSGEGGRVQITETSKILLENEYPEFIIEIRGINKDVKQDDFVTYWLTGKD--EDYFKKKN 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	19/46 (41%)
		CYCc	686..881	CDD:214485	66/207 (32%)
		Guanylate_cyc	722..895	CDD:278633	53/185 (29%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575
		PKc_like	534..804	CDD:419665
		CYCc	840..1033	CDD:214485	71/219 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810