DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	288	Identity:	90/288 - (31%)
Similarity:	140/288 - (48%)	Gaps:	35/288 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1247 EEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELE 1311
            |..|::|..:....:||..:||..||| .|.....::..|.|:   |.:.|:.|..|:    .:.
Mouse   871 ERTEELEQEKQKTDRLLTQMLPPSVAE-ALKMGTSVEPEYFEE---VTLYFSDIVGFT----TIS 927

  Fly  1312 GNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMAD 1376
            ..:|.:|.:.|||::...||.::....   :.|:::.|..||.||||......|    |...:|:
Mouse   928 AMSEPIEVVDLLNDLYTLFDAIIGAHD---VYKVETIGDAYMVASGLPQRNGQR----HAAEIAN 985

  Fly  1377 YALQLFDKIEEVNMHSFNN--FRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVD 1439
            .:|.:...:....|.....  .|:|||::.||.||||:|...|:|.::|:.||.||||:||||..
Mouse   986 MSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1050

  Fly  1440 HIQVTQEMQQILEG--RGFELTCRGSVDVKGKGSMITYFLKGR----RPI--------DAKELEL 1490
            .|.|.....:||..  :||::.|||..::||||...||:|.||    :||        .|....:
Mouse  1051 RIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPGASNHGI 1115

  Fly  1491 AKTEVEPPKTLTLAKEPEKLDSGTATEK 1518
            :..|:.|.:    .|:.||...|..|.|
Mouse  1116 SLQEIPPER----RKKLEKARPGQFTGK 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485	62/199 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	66/197 (34%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945
		HNOBA	<854..899	CDD:400168	10/28 (36%)
		CYCc	879..1070	CDD:214485	63/205 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810