DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus

Alignment Length:	281	Identity:	89/281 - (31%)
Similarity:	138/281 - (49%)	Gaps:	49/281 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1229 HQTEATYRLDFIWKL--QATEEKEDM-----EHLQAYNRK---LLENILPVHVAEHFLSREKHLD 1283
            :|.:.|..:|.:.::  :.:|..||:     |.|:...||   ||..:||..|| |.|.....::
Mouse   816 NQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVA-HALKMGTTVE 879

  Fly  1284 DLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKST 1348
            ..|.:|   |.|.|:.|..|:    .:...:|.:|.:..||::...||.:|....   :.|:::.
Mouse   880 PEYFDQ---VTIYFSDIVGFT----TISALSEPIEVVGFLNDLYTLFDAVLDSHD---VYKVETI 934

  Fly  1349 GATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRM----------RIGIN 1403
            |..||.||||.....:|    |...:|:.||.:        :....||||          |.|::
Mouse   935 GDAYMVASGLPRRNGNR----HAAEIANLALDI--------LSYAGNFRMRHAPDVPIRVRAGLH 987

  Fly  1404 IGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEG--RGFELTCRGSVDV 1466
            .||.||||:|...|:|.::|:.||.||||:||||...|.|:|...|.|..  .|:::..||..::
Mouse   988 SGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTEL 1052

  Fly  1467 KGKGSMITYFLKGR----RPI 1483
            ||||...||:|.|:    ||:
Mouse  1053 KGKGLEETYWLTGKVGFCRPL 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485	68/210 (32%)
		Guanylate_cyc	1285..1479	CDD:278633	68/205 (33%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557
		PK_GC-2D	554..818	CDD:270945	0/1 (0%)
		CYCc	855..1044	CDD:214485	68/211 (32%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910