DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	976	Identity:	200/976 - (20%)
Similarity:	324/976 - (33%)	Gaps:	335/976 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 PMI----------YQRDETQLLQPGDASNL--------EANN----PMSSGGGGGTANGPVSPSI 230
            |||          |:...|::|.|  |..|        :.||    |.|........||. .|..
Mouse   140 PMISAGSYGLSCDYKETLTRILPP--ARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGS-EPED 201

  Fly   231 SFWFRLNRI---------------ILR--------------------LCST-HQFKNLQ------ 253
            .||: ||.:               :||                    :|.| ..|.:::
Mouse   202 CFWY-LNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVA 265

  Fly   254 -------VEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTSLLLEISEIGL 311
                   |::....||    :.|||....:...|:|.|........|....|.:|...:.|...|
Mouse   266 EDTVVILVDLFSNHYF----EENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYL 326

  Fly   312 DANATVGNLTTATMK------------------------PPTLASSDQMTRGSSIPLLALASNGS 352
            :.....|::....::                        |.||..|..:....|:..::|.:...
Mouse   327 EGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKY 391

  Fly   353 WAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQK----------------------------- 388
            ..        |.....|.........|...:|:..|
Mouse   392 KV--------LMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLL 448

  Fly   389 ------RKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADV 447
                  || |||.|..|.|..||                         |.::.|....|::...:
Mouse   449 IALLVLRK-YRRDHALRQKKWSH-------------------------IPSENIFPLETNETNHI 487

  Fly   448 YTVASDDD---DDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGY 509
             ::..|||   |.:.              |||   |..:.::..:|..       ..:||.....
Mouse   488 -SLKIDDDRRRDTIQ--------------RVR---QCKYDKKKVILKD-------LKHSDGNFSE 527

  Fly   510 GQLIPL-ILMQVDESVLV--FLIVML---ICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLA 568
            .|.|.| .|:|.|...|.  :..|.|   |.|:|.   .|  .:.::.|:....:||.. |||:.
Mouse   528 KQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVE---YC--ERGSLREVLNDTISYPD-GTFMD 586

  Fly   569 IEVAVSYAMQPSKSFN-------------GSACCIVLIYMTYTM-----------------LPLR 603
            .|..:|.....:|..:             .|..|:|...|...:                 .|..
Mouse   587 WEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEH 651

  Fly   604 LREALIG-------------GILLSVVHLYT--C---------------------LRLNAMQDEA 632
            ||:|.|.             .|:|.....||  |                     |.|....::.
Mouse   652 LRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKE 716

  Fly   633 VEMI-----HWEE----------LLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARL- 681
            :|:.     .|||          :..|     ||.:.|:: |..|.::.....|...|.....|
Mouse   717 LEVYLLVKSCWEEDPEKRPDFKKIEST-----LAKIFGLF-HDQKNESYMDTLIRRLQLYSRNLE 775

  Fly   682 -----RTQ---RENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADIC 738
                 |||   .|..:.:.|...:|||.|...:|:....:|          :.:|.|:|.|:||.
Mouse   776 HLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEP----------ELYEEVTIYFSDIV 830

  Fly   739 GFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPD-HAHCAVEM 802
            |||::....|..|:|.:||:::..||::...|...:::.:||.|...||||....: ||....:|
Mouse   831 GFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKM 895

  Fly   803 GLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGR 865
            .||::..|..  :..:..:.|.:|:|:|:|....||:|:...::.::.:.|..|:.|||.|:|.|
Mouse   896 ALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLR 960

  Fly   866 VHITKET---LKCLDGDYEVEV-------GKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRL 920
            :|::..|   ||..|..:..||       |:|.|...:|...:.:.|.: |..   |..:::.||
Mouse   961 IHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNL-PSP---PTVENQQRL 1021

  Fly   921 Q 921
            |
Mouse  1022 Q 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	56/291 (19%)
		CYCc	686..881	CDD:214485	59/200 (30%)
		Guanylate_cyc	722..895	CDD:278633	56/185 (30%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	49/290 (17%)
		PKc_like	480..749	CDD:304357	57/304 (19%)
		STYKc	502..744	CDD:214568	50/262 (19%)
		CYCc	787..978	CDD:214485	59/200 (30%)
		Guanylate_cyc	814..1001	CDD:278633	58/196 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810