DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gucy2f

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	261	Identity:	80/261 - (30%)
Similarity:	131/261 - (50%)	Gaps:	52/261 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 RLRTQR---ENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFT 741
            |.||:.   |.|:.|:||..:||..||..:|...:.:|          :..:.|:|.|:||.|||
Zfish   841 RERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEP----------EYFDQVTIYFSDIVGFT 895

  Fly   742 SLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPD-HAHCAVEMGLD 805
            ::|......|:|.|||:|::.||.:...|...:::.:||.|...||||:...: ||.....|.|:
Zfish   896 TISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLN 960

  Fly   806 MIDAIA--LVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHI 868
            ::.::.  .:|.:..|.|.:|:|||:|....||:||...::.::.:.|..|:.|||.|:|.|:|:
Zfish   961 ILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV 1025

  Fly   869 ---TKETLKCLDGDYEVEV-------GKGNERNSYLKDHQIETYLIV----------------PG 907
               |.:.|:.|:..|:::|       |||.|          |||.:|                ||
Zfish  1026 NISTVQILRSLNDGYKIDVRGKTELKGKGIE----------ETYWLVGKANFTKPLPNPPEIKPG 1080

  Fly   908 D 908
            |
Zfish  1081 D 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	14/42 (33%)
		CYCc	686..881	CDD:214485	64/200 (32%)
		Guanylate_cyc	722..895	CDD:278633	59/185 (32%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..816	CDD:270945
		HNOBA	<825..870	CDD:311573	12/28 (43%)
		CYCc	850..1042	CDD:214485	65/201 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810