Protein Alignment CG43373 and LOC1272957

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_061519369.1
• Gene: LOC1272957 / 1272957
• VectorBaseID: AGAMI1_006876
• Length: 1413
• Species: Anopheles gambiae
• Alignment Length: 1587
• Identity: 754/1587 - (47%)
• Similarity: 955/1587 - (60%)
• Gaps: 285/1587 - (17%)

  Fly    24 IFRSLSSESQKREWSKRLSLRGMRHGGAAGGPGGSGTSSLASSKEESKHRKFFSRSASLRQAGSG 88
            :.||.|:|:|.|:||||.|||..:..      ...|....||.::    .||..|.:||||..:
Mosquito     7 LLRSFSTENQNRDWSKRFSLRIKQKS------SNDGKLDFASLRK----NKFARRCSSLRQQPT- 60

  Fly    89 GGGVGVGGVVGGSGSHQASMELHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKG 153
                       ...:...::||.         |:......|..:.|:|||..|||||||.::.:|
Mosquito    61 -----------EQTTSSVTLELE---------SASPAHSMTIHENSSPKKPKWEVIEHFKSNVRG 105

  Fly   154 GKAVVSSSLIAAGITRCNIDESMDSTNSSSTCHSPMIYQRD--------ETQLLQPGDASNLEAN 210
            .:: :||||||||:|..|:|::  ::|.|.|   |.|.::.        ..:.|:|  .:||..|
Mosquito   106 QES-ISSSLIAAGVTAFNLDDT--TSNYSGT---PSIRKKSFQIYSGAAAQEELEP--LNNLNIN 162

  Fly   211 NPMSSGGGGGTANGPVSPSISFWFRLNRIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILA 275
            |         .|.| |..:...|..:..:...:..:|:|||:|||||||||||||||||..||:.
Mosquito   163 N---------AAEG-VFDTSRCWNTVKCLFNGVICSHKFKNVQVEMLYQRYFLRMNQSNAVHIVW 217

  Fly   276 LLLALILALSCTLLVFTTLQLRRSTSLLLEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGS 340
            |||.||..|:...||||.: |::|.....|....|:                |.....|....||
Mosquito   218 LLLGLIFILALIHLVFTFI-LQQSLESCYESPLDGV----------------PGGIGQDAQINGS 265

  Fly   341 SIPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSH 405
            ::..:|..:..|:.      ..|.|.....:.  ..|...|...|.|       |.....:..:.
Mosquito   266 TLAAIAFGNGSSYE------DPLGSNRTEEVE--PPDRPDQQPKRAQ-------LESRTEEQGAT 315

  Fly   406 QQHR-TRYRMREKRSLQDAGLVKGG---GIQTQLIVDTATDDDAD-----VYTVASDDDDDVDGG 461
            :.|| :.||..||   .|.|....|   |::.|   .|....||:     |..||.:|:||..|.
Mosquito   316 EAHRLSGYRGNEK---DDPGGFSEGQNEGVRLQ---RTRRRWDAESGTVVVLPVADEDEDDGFGW 374

  Fly   462 RSAGSKHITYT--------------------PRVRDYNQISHAERDE------------------ 488
            ||.|.:...:|                    |..:| |::...:.||
Mosquito   375 RSGGGRAKRWTRGHANHRNNVDVAVRAADSVPPSQD-NELHRQDNDERRRKYGTAAEARELDAGS 438

  Fly   489 -----VLNTSSNAGVAT----------------DNSDPPL---GYGQLIPLILMQVDESVLVFLI 529
                 ..:|||::.:.|                ::.|.||   .|..|:...:.|:        |
Mosquito   439 EAYGTASSTSSSSSIVTTPTAMPQPANVSSDYSEDGDIPLCNRDYFTLLKDNMTQI--------I 495

  Fly   530 VMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIY 594
            |:.:|..|||.||..|.|..:|||:|..|||||:.|.|.::|..|:.....|..:...|.::.||
Mosquito   496 VLGVCATVYALLLMCLYKQRINEIYLFQVSYVIMVTLLVLDVCFSFTTSAKKFTSSGGCTVIAIY 560

  Fly   595 MTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTH 659
            :.|||||:|||||::||.|||:.|:.....:|...|..|       |.|.|:.|...|.||:..|
Mosquito   561 IIYTMLPIRLREAVVGGSLLSISHIALMFYMNESDDMDV-------LYCDLITLACTNATGILLH 618

  Fly   660 WPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYI 724
            |||||:|||||:|||||:||||:.|||||:||:|||||||||||||||:|||||||:.|||||||
Mosquito   619 WPKEKSQRKAFMETRQCVEARLKIQRENQKQEQLLLSVLPRHVAMEMKNDIAGQPREAQFHKIYI 683

  Fly   725 QRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 789
            |||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
Mosquito   684 QRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAQEHHCLRIKLLGDCYYCVSGLP 748

  Fly   790 EPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLA 854
            |.|||||.||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
Mosquito   749 EARPDHALCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLRKWQFDVWSNDVTLA 813

  Fly   855 NHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDI-YRPHKKSRN 918
            |:|||||:|||||||||||:||...|:||.|:|.:||||||||||:||||||.|. ||||..|:.
Mosquito   814 NYMESGGVPGRVHITKETLRCLGDHYDVEEGRGADRNSYLKDHQIQTYLIVPKDASYRPHTMSKQ 878

  Fly   919 RLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQ 983
            ...|||||||||||||      |.||.||.|.:| .|..|:||||||::||||||||.||.:||:
Mosquito   879 SSSVNGNISKELRMMG------HWSKMGFNDKTE-PKSTEEEVNEYLIKAIDARSIDRLRLDHCK 936

  Fly   984 SLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQS--------SLLTLALSTG 1040
            ...|.|..:.:||||..|||.||.||||||:::.||...::::||..        .:|:|.|
Mosquito   937 RFHLTFIKDEIERKYCLEPDPMLNVYFYCSIIIFLGIMSIQVLVFSMDHYSYWVYGILSLTL--- 998

  Fly  1041 ALLLLGFLVFLVACHKI----NFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQE 1101
                      ||:|..:    :.::.:..:..|.:||.:|.|:|:     ::|.|:.|::.:
Mosquito   999 ----------LVSCVPVFTREDMKVSTFFRALSQKIHGHREIAQV-----ISLCVVITVICL--- 1045

  Fly  1102 SGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEP-----DCDFYLAYNTFLLLTLLSMMSC 1161
            |..::.|:    |:|               .:|| |.|     :|......|..||||||::::|
Mosquito  1046 SYYKLTLI----FYL---------------SLYD-EFPLVRPSNCKESKIINILLLLTLLALLTC 1090

  Fly  1162 ATYQVLRILLKLLLLLLASGSYMA---CSSNLYSRSRE---MSQELANEEALLRYIIDSIFLFAF 1220
            |.:|.::||.|:|||::....|:|   ..:.::.|..|   ::.|        |::||..||..|
Mosquito  1091 AVHQFIKILFKILLLIVILVLYIASIIVLALIFERHCEPWFLTTE--------RFLIDVAFLVVF 1147

  Fly  1221 MLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDL 1285
            ::..|.||.|||.|.||||||||||||||||||||||||||||.||||||||:|||.|||:::::
Mosquito  1148 VIGQIMHSQQTEITRRLDFIWKLQATEEKEDMEHLQAYNRKLLANILPVHVADHFLMREKNIEEI 1212

  Fly  1286 YHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGA 1350
            ||||||:||::|||||||||||:|||||||||||||||||||.||||||..||||.:||||:||:
Mosquito  1213 YHEQCDTVCVMFASIPNFSEFYIELEGNNEGVECLRLLNEIIVDFDELLGLERFRYVEKIKTTGS 1277

  Fly  1351 TYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGAC 1415
            |||||||||||:||:.:|.||.||.||||:||.||.:||.|||||||||||||||||||||||..
Mosquito  1278 TYMAASGLTANSCDKNDFQHVFAMMDYALELFQKITDVNEHSFNNFRMRIGINIGPVVAGVIGTR 1342

  Fly  1416 KPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGR 1480
            ||||||||||||||||||||||:||||||:::.||::.:|:.|||||:|:|||||:||||.:.|
Mosquito  1343 KPQYDIWGNAVNVASRMDSTGLMDHIQVTEDVYQIVKDKGYNLTCRGTVNVKGKGTMITYLMPG- 1406

  Fly  1481 RPIDAKELELAKTEVEPPKTLTLAKEP 1507
                                  |||||
Mosquito  1407 ----------------------LAKEP 1411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	103/196 (53%)
		Guanylate_cyc	722..904	CDD:425528	165/181 (91%)
		Adcy_cons_dom	<949..1005	CDD:461877	31/55 (56%)
		Guanylate_cyc	1285..1479	CDD:425528	151/193 (78%)
LOC1272957	XP_061519369.1	None