Protein Alignment CG43373 and Adcy2

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_061516922.1
• Gene: Adcy2 / 1272602
• VectorBaseID: AGAMI1_014459
• Length: 1227
• Species: Anopheles gambiae
• Alignment Length: 1228
• Identity: 402/1228 - (32%)
• Similarity: 580/1228 - (47%)
• Gaps: 323/1228 - (26%)

  Fly   515 LILMQVDESVLVFLIVM-----LICGIVYAFLLCILSKPAMNEIFLVLVSYVIL--GTFLAIEVA 572
            ::|..:.:::|..:.::     ::|||:.|     |..||:....|..:|:.||  ||..||...
Mosquito    66 IVLCALHDAILADVALLAGASTVLCGILVA-----LQFPAVMNSPLAALSFAILTTGTIGAISTF 125

  Fly   573 VSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHL-YTCLRLNAMQDEAVEMI 636
            |...:.|...|       .||...:||||:....:::..:||.:||: |..|          ..:
Mosquito   126 VGTQLAPLPLF-------ALILGVHTMLPISWPVSVVLAVLLCIVHIGYRIL----------SQV 173

  Fly   637 H------WEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLL 695
            |      :.:||...|.|..|:::.:|.....:.|...|...||..||.|::.:.|.:|||:|||
Mosquito   174 HDFPPTFFPQLLAETVFLASASVSSLYYRIMSDAAHIDAVDGTRTGIEQRVKLECEREQQEQLLL 238

  Fly   696 SVLPRHVAMEMKDDI----------AGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAE 750
            ||:|.::|.|:|..|          ||....|:||::::|||.|||||:|||..||.||:|.||.
Mosquito   239 SVIPAYIAAEVKRSIMLKMADACQRAGGQTQTRFHEMHVQRHNNVSILYADIVNFTPLSEQLTAS 303

  Fly   751 ELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVRE 815
            :||:.|||||.|||::|.|:.|||||:||||||||||||..||.||...|.|||.|||||..|||
Mosquito   304 DLVKTLNELFGRFDQIAQENQCLRIKILGDCYYCVSGLPVSRPHHAANCVNMGLQMIDAIRFVRE 368

  Fly   816 VMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDY 880
            ....||:||:|||||.|.||||||.||||||||:||||||||||||:.|||||||.||..|...:
Mosquito   369 ATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKATLDYLGDMF 433

  Fly   881 EVEVGKGNERNSYLKDHQIETYLIV---------------------------------------- 905
            |||.|.|..|.|||.||:|||||||
Mosquito   434 EVEPGGGASRESYLADHKIETYLIVPPKKPPTDLGKPATADSHTPTSNIGTPSPTTMVQITEPDQ 498

  Fly   906 ---------------------PGDIYRPH-----------------------------------K 914
                                 |.|:.|.|                                   .
Mosquito   499 EHLLPALEPPKTPKTPRAPKTPDDVRRSHASISPITIPEEQEQLLPPSPANIASGGHGLLPPPSP 563

  Fly   915 KSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKD-----PEDEV--NEYL------- 965
            .|:..:|:|.....|..:...|||    .:.|..|..||.|.     |.:.:  |.:|
Mosquito   564 NSKQTVQINPPTINEETVDNDGTA----DETGEADEGESRKKSCLTLPVEPITTNGHLPERVGSR 624

  Fly   966 -----------------------MRAIDARSIDHLRAE--------------------------- 980
                                   ||.:...:||.||:.
Mosquito   625 KLSVQGLIAFAERRKSSSSIFGDMRKMSISNIDCLRSPMVATPGGPLLRTRPSSKMTKYVECWGA 689

  Fly   981 ---------------------------------HC------------QSLLLCFKDNVLERKYAS 1000
                                             :|            |.:.:.:::...|..:.:
Mosquito   690 DKPFANITDSKMAKNIGLASIAMIESNLLPEDGYCGECKCWGPPKELQPVTMWYRNTARETLFRA 754

  Fly  1001 EPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDI 1065
            :|:........||.::.|...:::::||:|:::.:...:...:.||..::|     .|:|:.
Mosquito   755 QPEPTFRFDLICSFILFLTIGLIQIIVFKSNVVVIGSLSATAVALGLFLYL-----SNYQMS--- 811

  Fly  1066 KRFSLRIHSNRRISQLFAFA---SVALIVLTTLL----AMFQESGRQMELLQRRRFWLDVNGSIS 1123
               :|....|....|:.|.:   .:|:.::||.|    |:|........::....|   ||
Mosquito   812 ---NLSPPGNNGPGQVIAASRGLRLAIFLITTALIASCAIFSVINFDDLVIADIHF---VN---- 866

  Fly  1124 LNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLK--LLLLLLASGSYMAC 1186
             |.||  ..|||.|     |......:|.:..:|:.:.:.:.....|:|  |:.:.:|..|.:..
Mosquito   867 -NTTE--DIMYDDE-----FAPVAPVYLYMCAISLAAVSAFLKAGFLVKGMLMAIFVAIQSSVLW 923

  Fly  1187 SSNLYSRSREMSQELANE-----EALLRYIIDSIFLFAFMLALIFHS--HQTEATYRLDFIWKLQ 1244
            :|:|:    |....|.|.     :.|         ||..:::.:.|:  .|.|...|.||:||.:
Mosquito   924 TSSLF----EAYGTLGNSWPLGFQGL---------LFLLLISAVLHTLDRQGEYAARTDFLWKAK 975

  Fly  1245 ATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVE 1309
            ...|:|::|.::..|:.|||||||.|||:|||.:|:.:.:||||...||.::||||||:.|||.|
Mosquito   976 LKVEQEEVETMRGINKILLENILPAHVAQHFLKKERAVQELYHESYSSVAVMFASIPNYKEFYDE 1040

  Fly  1310 LEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA---------NTCD- 1364
            .:.|.:|:||||||||||.|||:||.:.:|..|||||:.|:|||.||||..         |..|
Mosquito  1041 TDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIGSTYMIASGLRPGKEEGATKNNELDE 1105

  Fly  1365 -RVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNV 1428
             |....:|..:.::|:.|...::::|..||..||:|||:|.|||:||||||.|||||||.|.|||
Mosquito  1106 KRTEEHNVVVLVEFAIALMTALDQINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNV 1170

  Fly  1429 ASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAK 1486
            ||||||.|::..:|||:...::|...|:...|||.:.|||||.:.|||:|  .|.|.:
Mosquito  1171 ASRMDSCGVMGRVQVTENTAKVLMAAGYSCDCRGPIHVKGKGILTTYFVK--TPFDER 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	62/220 (28%)
		Guanylate_cyc	722..904	CDD:425528	124/181 (69%)
		Adcy_cons_dom	<949..1005	CDD:461877	17/164 (10%)
		Guanylate_cyc	1285..1479	CDD:425528	105/204 (51%)
Adcy2	XP_061516922.1	None