Protein Alignment CG43373 and Ac13E

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_061516135.1
• Gene: Ac13E / 1272181
• VectorBaseID: AGAMI1_002114
• Length: 1689
• Species: Anopheles gambiae
• Alignment Length: 1634
• Identity: 371/1634 - (22%)
• Similarity: 549/1634 - (33%)
• Gaps: 670/1634 - (41%)

  Fly   504 DPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVY-----------AFLLCILSKPAMNEIFLVL 557
            |.|:..||....:..|:.......|..:|:|.:|:           :|.|..:|   :..|||..
Mosquito    76 DSPVLEGQYQASVFPQLRLKFRFALFYILLCSLVWLLYFLFDGGPTSFTLLTVS---IGLIFLFA 137

  Fly   558 VS---------------------YVILGTF-LAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTML 600
            ::                     .|:|..| |.:.:....|:.|...|   :.||.::.:.||::
Mosquito   138 LAGLWVTRTDLYRAHTHLLSSCCAVLLCLFSLCLLLLTREALSPLGHF---SICIEIVMLIYTII 199

  Fly   601 PLRL-------REALIGGILLSVVH----------------------LYTCLRLNAMQ------D 630
            ||.|       ....:...:||.:|                      :.|..||.|.:      |
Mosquito   200 PLPLWLCCTITMAYSVCFEVLSFLHQTHYDYNSRPGGQPTVSPLAAGITTAARLLAEEVAIAGSD 264

  Fly   631 EAVEMIH----------------WEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEA 679
            :..:..|                ::.:|..::..|..:|.|:..........|..|::..|.:..
Mosquito   265 QQQQHHHHQHHHHHHHQTGDSFVYKIVLIRVLIQLCVHLIGIQILIMTVVRMRGTFMKVGQNLLV 329

  Fly   680 RLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHK--------------------IYI 724
            |.:.:.|.|.:|:::.|::|..||..:..:....|:.|.|.:                    .::
Mosquito   330 RRQLEMEKQLKEKMIHSMMPPKVADLLLKESGSVPKGTSFDQYPAPGGRRTTPSDLKSLFRPFHM 394

  Fly   725 QRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 789
            .|.||||||||||.|||.:|...|||:||.:||:||.|||.|...:.|.:|..||||||||||.|
Mosquito   395 NRMENVSILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCLVNGCEKISTLGDCYYCVSGCP 459

  Fly   790 EPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLA 854
            |||||||.|.|||||.||::|.:........:.||||:|||.|.||::|..:.:|||||||||||
Mosquito   460 EPRPDHAICCVEMGLGMIESIRVFDAQRNEGIKMRVGVHTGTVLCGIVGTKRVKFDVWSNDVTLA 524

  Fly   855 NHMESGGIPGRVHITKETLKCLDGDYEVEVGKG-------------------------------- 887
            |.|||.|.|.:||:::||...|...|.:|.|:.
Mosquito   525 NRMESSGKPDQVHVSEETCGFLGDSYIIEEGEEVDGHRTYFVLGKRLDLVGSITEGLSSIGLPVD 589

  Fly   888 ------------NERNSYL--KDHQIETYL------------IVP-----GDIY----------- 910
                        :|...|.  ::|...:.|            .||     |.::
Mosquito   590 LNLLGASSPSPLDELRDYATSEEHPESSCLSRSATNLSSIQPAVPPASPAGPVFFSSLHASPVST 654

  Fly   911 -RPHKKSRNRLQ------------------------------------------VNG-------- 924
             ||...|..::.                                          .||
Mosquito   655 PRPRIASLTKMTKFLRSAVSKGDGGGRLLNAGRTPPAPPPVVEKPKIIISTKSISNGFDSDDDDD 719

  Fly   925 --------NISKELRMMGHGTA-------------------------------QKHTSKFGFGDS 950
                    |...||..||.|..                               |:...:.|.|..
Mosquito   720 DRGGGGGCNEDDELVGMGGGAGRGRARSPASPRQSMTQEAPPTTLAMLNERRKQEGGGEAGVGQR 784

  Fly   951 S-------------------ESAKDPEDEV-------NEYLMRAIDARSIDHLRAEH-------- 981
            .                   :|:|..:|:|       :.....|.:.::|.:...:|
Mosquito   785 KPPGRVLKVGAPEPDCGRICDSSKSCDDDVPCIERMGSSSSNSASNNQNITNGCYQHVPIVIVTP 849

  Fly   982 ---CQSLLL---------------------------CFK-DNVLERKYASEP---DRMLCVYFYC 1012
               |.:|.:                           |.| ..|.|..:||:.   |.::.|..|.
Mosquito   850 RPSCHTLDVANGGTPAPPASGAPTASGSCSAARSRDCGKGPTVGENPHASQGSVFDEIIDVRSYI 914

  Fly  1013 S-----LLVLLGTSIMRLVVFQSSLL-TLALSTGALLLLGFLVF--------------------- 1050
            |     :.....|...|....:||:: .:|||.||........|
Mosquito   915 SQSRSDISPFARTGSYRSQADRSSIIHEIALSAGAPGGSNSGTFGRPRSSTITTTHHHTCSEAHQ 979

  Fly  1051 ------LVACHKINFQL--------PSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQE 1101
                  :|.|...:..|        ||...|....|.||.|.|.:  ...:.|:..|..|::.:.
Mosquito   980 HVRHGSVVVCPSSSRLLGADGASLSPSATSRKDSGIRSNSRRSSI--QHQLMLMSQTVALSVHRV 1042

  Fly  1102 SG----RQMEL------------------------------------------------------ 1108
            ||    .|..|
Mosquito  1043 SGYFTSSQSSLSGAIVTSAAGVPRAHKPNGSMRAGTIATAANSGGAAAAAAPGSRCCMGLKEPHP 1107

  Fly  1109 ------LQRRRFWLDVNGSISLNDTELNTKMYDAEEP-------------DCDF----------- 1143
                  ||:.|...|:.....:.|...:.:.|..:.|             :.:|
Mosquito  1108 DPLAACLQQLRKQSDLQLIRCVRDNARSQRSYLVKPPLLPISLRFKSRPMEQEFRSKAHRFGSEG 1172

  Fly  1144 -----------------------------YLAYNTFLLL-----------------------TLL 1156
                                         |||.:|.|.|                       .|.
Mosquito  1173 GDLLEGGSPPTLATPKYNTYIDMLVSFVVYLATSTSLFLLSPSVYLESYKVWVCIFVFFSTVQLF 1237

  Fly  1157 SMMSCATYQVLRILLKL---------------LLLLLASGSY----------------------- 1183
            ::..| |.||.|...|.               .||.|||..|
Mosquito  1238 ALFIC-TKQVCRRTRKPTVRRSRPVATRSCYDCLLQLASAWYPWHICGGILMSLPVISILSNFAM 1301

  Fly  1184 -------------------------------------MACSSN-----------LYSRSREMSQE 1200
                                                 |||.::           :..::.|::..
Mosquito  1302 MDVTKFRVFEFHYGFLMYICIVHFCNFTQLNWWMRNAMACITSAAFVGIAVGHMVELQALEVATA 1366

  Fly  1201 L----------ANEEALL-------------------------RYIIDSIFLFAFMLALI-FHSH 1229
            .          ||..|||                         .|.::.......:|.|: |.:.
Mosquito  1367 AAAAAAAATLGANGTALLAAGGGGGDGAGGNEMLHRAQFDWFNNYRVEIYVDLLLLLVLVWFLNR 1431

  Fly  1230 QTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVC 1294
            :.|..|||.|.....|.::|..:::::.....||.||:|.||||...:..|     |.|...::.
Mosquito  1432 EFEIGYRLSFHGSAVANQDKIRVQNMKNQADMLLHNIIPKHVAEQLKNTAK-----YSENHHNIG 1491

  Fly  1295 ILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT 1359
            |:||||.||:|.|.  |....|.|.||:|||:|.||||||:...|||:||||:.|:|:||||||.
Mosquito  1492 IIFASIVNFNEMYD--ESYLGGKEYLRVLNELIGDFDELLARPEFRCVEKIKTIGSTFMAASGLD 1554

  Fly  1360 ANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFN------NFRMRIGINIGPVVAGVIGACKPQ 1418
            .::... .:.|:..:.|:||.:...:|     |||      |..||:|.|.|.|.|||||..|..
Mosquito  1555 PSSRGE-TYEHLYTLLDFALAMQQVVE-----SFNRDLLEFNLIMRVGYNFGDVTAGVIGTSKLY 1613

  Fly  1419 YDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRP- 1482
            |||||:||||||||||||:...:||..:...:| |..::...||.|.||||..|..|.|.|::|
Mosquito  1614 YDIWGDAVNVASRMDSTGVAGRVQVGADCIPVL-GERYDFQPRGKVYVKGKDHMEVYLLVGKKPD 1677

  Fly  1483 -IDAKELEL 1490
             :...||::
Mosquito  1678 LLGPPELDI 1686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	50/280 (18%)
		Guanylate_cyc	722..904	CDD:425528	97/239 (41%)
		Adcy_cons_dom	<949..1005	CDD:461877	16/123 (13%)
		Guanylate_cyc	1285..1479	CDD:425528	93/199 (47%)
Ac13E	XP_061516135.1	None