DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43373 and LRRK2

DIOPT Version :9

Sequence 1:NP_001097622.2 Gene:CG43373 / 39835 FlyBaseID:FBgn0263131 Length:1854 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:1227 Identity:219/1227 - (17%)
Similarity:403/1227 - (32%) Gaps:441/1227 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   672 ETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFAD 736
            ||.:.:..||...:|.:|.|.|          :::.:|:.......:..|::..::.:|.:|   
Human    14 ETLKKLIVRLNNVQEGKQIETL----------VQILEDLLVFTYSERASKLFQGKNIHVPLL--- 65

  Fly   737 ICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVE 801
                              ::.:.:.|...:......|..||:..|...:..|..|:        :
Human    66 ------------------IVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQ--------D 104

  Fly   802 MGLDMIDAIALVREVMAVN--VNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPG 864
            :|.|.        ||:.|:  :...:.:|...|:..|:||           .||...:.||    
Human   105 VGNDW--------EVLGVHQLILKMLTVHNASVNLSVIGL-----------KTLDLLLTSG---- 146

  Fly   865 RVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKE 929
                 |.||..||.:.::.:...:..:|:                     .:.:.:|..|  .|.
Human   147 -----KITLLILDEESDIFMLIFDAMHSF---------------------PANDEVQKLG--CKA 183

  Fly   930 LRMMGHGTAQKHTSKF--------------GFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAE 980
            |.::....:::..::|              .|.|        |:|:..:::..:      |..|.
Human   184 LHVLFERVSEEQLTEFVENKDYMILLSALTNFKD--------EEEIVLHVLHCL------HSLAI 234

  Fly   981 HCQSL-------LLCFKDNVLERKYASEPDRMLCVYFYCSLL--VLLGTSIMRLVVFQ------- 1029
            .|.::       :.|:  |::.....:.|.........|.||  :.||.....||:.:       
Human   235 PCNNVEVLMSGNVRCY--NIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVK 297

  Fly  1030 -------------SSLLTLALSTGALLL------------------LGFLVFLVACHKINFQLPS 1063
                         |:|..|||.|..:.|                  ...|.:|.||:|       
Human   298 AVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYK------- 355

  Fly  1064 DIKRFSLRIH-SNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDT 1127
                 :|..| .|:.:.:...:|      |..|| |:|.|                         
Human   356 -----ALTWHRKNKHVQEAACWA------LNNLL-MYQNS------------------------- 383

  Fly  1128 ELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLL--------LLLASGSYM 1184
             |:.|:.|.:    ..:.|:...:|..|:...|...:|.....|..||        :||:.|.::
Human   384 -LHEKIGDED----GHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHL 443

  Fly  1185 ACSSNLYSRSRE--MSQELANEEA-LLRYIID----SIFLFAFM---LALIFHSHQTEATYRLD- 1238
                |:....::  .|.|:|.... :|.::.:    |:.:.|.:   :..:...|:|....:|: 
Human   444 ----NVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 504

  Fly  1239 ------FIWKLQATEEKEDMEH--------------------LQAYNR------------KLLEN 1265
                  ||......|.:||.|.                    |.|.||            |::.:
Human   505 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISS 569

  Fly  1266 ILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECL---------- 1320
            |:....|...||.|..:|.:.|.                   :::..:::.::||          
Human   570 IVHFPDALEMLSLEGAMDSVLHT-------------------LQMYPDDQEIQCLGLSLIGYLIT 615

  Fly  1321 ---------RLLNEIIADFDELLSEERFRCIEKIKSTG-ATYMAASGLTANTCDRVNFSHVTAMA 1375
                     .||.:|:..     |..||:.:.:|::.| .|.:|...|:|      :||.:....
Human   616 KKNVFIGTGHLLAKILVS-----SLYRFKDVAEIQTKGFQTILAILKLSA------SFSKLLVHH 669

  Fly  1376 DYALQLF----DKIEEVNMHSFNNF--RMRIGINIGPVVAGVI--GACKPQYDIW-------GNA 1425
            .:.|.:|    ..|.|.....|.|.  :....:.:...:..|:  .||.....|.       |..
Human   670 SFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGAD 734

  Fly  1426 VNVASRMDSTGLVDHIQVTQE------MQQILEGRGFELTCRGSVDVK-GKG-SMITYFLKGRRP 1482
            .|.|.  :.:.|:  .||.::      ::.:|.....|...|.::.:. ||| |.|...|..|..
Human   735 ANQAK--EGSSLI--CQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLA 795

  Fly  1483 IDAKELE-------LAKTE------VEPPKTLTLAKEPEKLDSGTATEKQREQVK---EQGSTEQ 1531
            :|.....       :.|.|      :.|.||..|.|: ..:.|..|....|.|:|   |:|:...
Human   796 LDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQ-TNIASTLARMVIRYQMKSAVEEGTASG 859

  Fly  1532 ED-----DLLPS-------PDIDMNSNMQNLTAQRRKSLCRQHNISSSFGTTVSSSTGITPSISN 1584
            .|     |:|..       ||    |:|.::.||           |....:..|..:.:....||
Human   860 SDGNFSEDVLSKFDEWTFIPD----SSMDSVFAQ-----------SDDLDSEGSEGSFLVKKKSN 909

  Fly  1585 SSSVVTIGAL--PAILRGGNPLSNANPNATDSCSECGGASKSLATPTAPPRTLVADLKDEIARDE 1647
            |   :::|..  .|:|:      ..:||.....:..|.               :.|.:|.:.|..
Human   910 S---ISVGEFYRDAVLQ------RCSPNLQRHSNSLGP---------------IFDHEDLLKRKR 950

  Fly  1648 KIGLKDSIENLEILLKNNISLSDLSNKQQQNLRGETSSSTTTTLRKRDTIVSFNVTE 1704
            ||            |.::.||.  |:|.|.::|...|.|:..:.|:..|.:..:..|
Human   951 KI------------LSSDDSLR--SSKLQSHMRHSDSISSLASEREYITSLDLSANE 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43373NP_001097622.2 AC_N <523..720 CDD:292831 9/47 (19%)
CYCc 686..881 CDD:214485 34/196 (17%)
Guanylate_cyc 722..895 CDD:278633 29/174 (17%)
DUF1053 <949..1005 CDD:283888 9/62 (15%)
CYCc 1259..1455 CDD:214485 43/248 (17%)
Guanylate_cyc 1285..1479 CDD:278633 42/236 (18%)
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 213/1201 (18%)
LRR 1 983..1004 2/11 (18%)
leucine-rich repeat 985..1012 CDD:275380 2/9 (22%)
LRR 1012..>1286 CDD:227223
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1084 CDD:275380
LRR 4 1059..1080
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1150
leucine-rich repeat 1131..1174 CDD:275380
LRR 8 1174..1196
leucine-rich repeat 1175..1197 CDD:275380
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1241
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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