DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Npr2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_446290.1	Gene:	Npr2 / 116564	RGDID:	620851	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	116/403 - (28%)
Similarity:	173/403 - (42%)	Gaps:	63/403 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1122 ISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLS--------MMSCATYQVLRILLKLLLLLL 1178
            :.:.|..|.:....||..|.....|...:....|||        |.....|....||.:   :.|
  Rat   658 LKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQE---IAL 719

  Fly  1179 ASGSYMACSSNLYSRSREMSQELAN-EEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDF--- 1239
            .||.:..  ..|....:|:.|::.| :....|..||...|...::.|:......:.|.|.||
  Rat   720 RSGPFYL--EGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQI 782

  Fly  1240 -------------------IWKLQA---TEEKEDMEHLQAY---NRK---LLENILPVHVAEHFL 1276
                               :.:::.   ..||...|..|||   .||   ||..|||..|||..
  Rat   783 KGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL- 846

  Fly  1277 SREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRC 1341
               |..:.:..|..|||.|.|:.|..|:    .|...:..::.:.|||::...||.::  :.|.
  Rat   847 ---KRGETVQAEAFDSVTIYFSDIVGFT----ALSAESTPMQVVTLLNDLYTCFDAII--DNFD- 901

  Fly  1342 IEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIE--EVNMHSFNNFRMRIGINI 1404
            :.|:::.|..||..|||......|    |...:|..||.|.|.:.  .:.....:..|:|||::.
  Rat   902 VYKVETIGDAYMVVSGLPGRNGQR----HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHT 962

  Fly  1405 GPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRG-FELTCRGSVDVKG 1468
            |||.|||:|...|:|.::|:.||.||||:|.|....|.|:...:..|:..| |:|..||.|::||
  Rat   963 GPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG 1027

  Fly  1469 KGSMITYFLKGRR 1481
            ||.|.||:|.|.|
  Rat  1028 KGKMRTYWLLGER 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485	65/200 (33%)
		Guanylate_cyc	1285..1479	CDD:278633	68/196 (35%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944	29/138 (21%)
		HNOBA	<798..846	CDD:400168	16/47 (34%)
		CYCc	825..1009	CDD:214485	64/198 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810