DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy9

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	1244	Identity:	350/1244 - (28%)
Similarity:	534/1244 - (42%)	Gaps:	275/1244 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 LGYGQLIPLILMQVD-ESVLVFLIVMLICGIV--YAFLLCILSK-----PAMNEIFLVLVSYVI- 562
            :|:..|:..|...|. :|.::.::|..:|.:|  ..|.|...:|     .|...:.|.|:.:.:
Mouse   123 VGFACLLWSIYFAVHMKSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALT 187

  Fly   563 LGTFLAIEVAVSYAMQPSK------------SFNGS-ACCIVLIYMTYTMLPLRLREALIGGILL 614
            |.....:...:|..:..|.            |..|| :.||.::.:.||::.|.|..:|..|::.
Mouse   188 LAAQFQVWTPLSGRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVY 252

  Fly   615 SVVHLYTCLRLNAMQDEAVE-----MIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETR 674
            ||  |:.....:...::...     .:|| |||...:..:..:..|::.....:...|..|::..
Mouse   253 SV--LFETFGYHFRNEDCYPSPGPGALHW-ELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVG 314

  Fly   675 QCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQ----------------PRDTQ----- 718
            |.|......:.|...:||::.||:||.:|    ||:..|                |::.:
Mouse   315 QSIMHGKDLEVEKALKERMIHSVMPRIIA----DDLMKQGDEESENSVKRHATSSPKNRKKKSSI 375

  Fly   719 ------FHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL 777
                  |....:|:.|.||||||||.|||.:|...:|..||.|||:||.|||||..:..|.:|..
Mouse   376 QKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKIST 440

  Fly   778 LGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKW 842
            ||||||||:|.||||.|||:|.:||||.||.||....:.....||||||:|||.|.||:||:.::
Mouse   441 LGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRF 505

  Fly   843 QFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNER--NSYLKDH--QIETYL 903
            :||||||||.|||.||..|:.|:|||::.|.|.||..||:|.|:..||  .|.:.|.  .::|||
Mouse   506 KFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVADQLKGLKTYL 570

  Fly   904 IVPGDIYRPHKKSRNRLQVNGNISKELR----MMGHGTAQ-------KHTSK------------F 945
            |........|......|.....:..:.|    ..|.|||.       ..|.|            .
Mouse   571 ISGQRAKESHCSCAEALLSGFEVIDDSRESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGI 635

  Fly   946 GFGDSSESAKD----------------------------------------PEDEVNEYLMRAID 970
            .|...||:..:                                        |..:....|:....
Mouse   636 TFAPKSEAGAEGGTVQNGCQDEPKTSTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPA 700

  Fly   971 ARSIDHLRAEHC---------------QSLLLCFK-DNVLERKYAS-----EPDRMLCVYFY--- 1011
            ...:.:.:...|               ||.||..: .|:.|:..|.     :.|.::..||:
Mouse   701 EEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPP 765

  Fly  1012 ---CSLLVL-------LGTSIMRLVVFQ-----------SSLLTLALSTGALLLLGFLVFLVACH 1055
               .||..|       ..||....|:..           ||||.:.|||...|:|....||....
Mouse   766 INQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYGA 830

  Fly  1056 KINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQME--LLQRRRFWLDV 1118
            ......|:.:..|...:           ...|..::::..:..|.|......  ||:....||..
Mouse   831 TATPPPPAALAVFGADL-----------LLEVLSLIVSIRMVFFLEDVMTCTKWLLEWIAGWLPR 884

  Fly  1119 N--GSISLNDTELNTKMYDAEEPDCDFYLA-------------YNTFLLLTLLSMMSCATYQVLR 1168
            :  |:|.::...|....:...|.:.:.::.             |..|..|:.....|.||.....
Mouse   885 HCIGAILVSLPALAVYSHITSEFETNIHVTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAG 949

  Fly  1169 ILLKLLLLLLASGSYM---------------ACSSNLYSRSREMSQELANEEALLRYIIDSIFLF 1218
            :||.|.:.|....|.:               .|:|::....|..: .|..:|.:|.:       |
Mouse   950 LLLLLHISLCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPA-SLIGKELILTF-------F 1006

  Fly  1219 AFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLD 1283
            ..:|.:.|.:.:.|.:|||.:...::|...:..::.::.....||.||:|.||||     :..:.
Mouse  1007 LLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE-----QLKVS 1066

  Fly  1284 DLYHEQCDSVCILFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKS 1347
            ..|.:..||..::||||.||||||.| .||   |.||.|:|||:|.|||||||:..:..|||||:
Mouse  1067 QTYSKNHDSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYNSIEKIKT 1128

  Fly  1348 TGATYMAASGLTANTCDRVNF--SHVTAMADYALQLFDKIEEVNMHS-FNNFRMRIGINIGPVVA 1409
            .||||||||||....|.....  .|:..:.::|.::...:::.|.:. :.||::|:|.|.||:.|
Mouse  1129 IGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTA 1193

  Fly  1410 GVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMIT 1474
            ||||..|..|||||:.||:|||||:||:...|||::|..::|...|::...||:|:|||||.|.|
Mouse  1194 GVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT 1258

  Fly  1475 YFLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLDSGTATEKQRE-----QVKEQGS-----T 1529
            |..                             |:..|:|...:.|..     :|:..||     |
Mouse  1259 YLY-----------------------------PKCTDNGVVPQHQLSISPDIRVQVDGSIGRSPT 1294

  Fly  1530 EQEDDLLPS 1538
            ::..:|:||
Mouse  1295 DEIANLVPS 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	49/249 (20%)
		CYCc	686..881	CDD:214485	103/221 (47%)
		Guanylate_cyc	722..895	CDD:278633	97/174 (56%)
		DUF1053	<949..1005	CDD:283888	13/116 (11%)
		CYCc	1259..1455	CDD:214485	91/199 (46%)
		Guanylate_cyc	1285..1479	CDD:278633	94/197 (48%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	28/127 (22%)
		Guanylate_cyc	385..573	CDD:306677	102/187 (55%)
		Guanylate_cyc	1069..1260	CDD:306677	93/193 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810