DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy8

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus

Alignment Length:	1576	Identity:	513/1576 - (32%)
Similarity:	718/1576 - (45%)	Gaps:	448/1576 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SGSHQASMELHVP--GQEGRGTSSGAGSPQTQTQPSTPKKSNWE-VIEH-----FNTSAKGGKAV 157
            |||.:.......|  |.:|.|              |.|::..|: .:.|     |....:||.
Mouse    10 SGSEELYTIQPTPPAGDDGSG--------------SRPQRLLWQTAVRHITEQRFIHGHRGGG-- 58

  Fly   158 VSSSLIAAGITRCNIDESMDSTNSSSTCHSPMIYQRDETQL--LQPGD-ASNL--------EANN 211
                  ..|::|    ::.:...|....|:|.:.......|  |.||: |.|.        .:.:
Mouse    59 ------GGGVSR----KASNPAGSGPNHHAPQLSSDSVLPLYSLGPGERAHNTGGTKVFPERSGS 113

  Fly   212 PMSSGGGGGTANG----PVSPSISFWFRLN-----RIILRLCSTHQFKNLQVEMLYQRYFLRMNQ 267
            ..:||.|||...|    ..:||.|.:| ||     |.::.....:.||:..:|.|||||||...:
Mouse   114 GSASGSGGGGDLGFLHLDCAPSNSDFF-LNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR 177

  Fly   268 S-----NTTHILALLLALILALSCTLLVFTTLQLRRSTSLLLEISEIGLDANATVGNLTTATMKP 327
            .     |...:|..|..|:|.||                                  |.:|.|.|
Mouse   178 KSEVVMNVLDVLTKLTLLVLHLS----------------------------------LASAPMDP 208

  Fly   328 PTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQKRKHY 392
                     .:|..:        |.:.|...|...|......|.:
Mouse   209 ---------LKGILL--------GFFTGIEVVICALVVVRKDNTS-------------------- 236

  Fly   393 RRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTVASDDDDD 457
                 |.|                   ||.:|:|....:.||::
Mouse   237 -----HTY-------------------LQYSGVVTWVAMTTQIL--------------------- 256

  Fly   458 VDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDE 522
                 :||                                         ||||
Mouse   257 -----AAG-----------------------------------------LGYG------------ 263

  Fly   523 SVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSA 587
                                                   :||                   :|..
Mouse   264 ---------------------------------------LLG-------------------DGIG 270

  Fly   588 CCIVLIYMTYTMLPLRLREALIGGI---LLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALL 649
            ..:..::.||:||||.|..|::.|:   ||.|.......||      ||..|:  ::|..:|..:
Mouse   271 YVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRL------AVFSIN--QVLAQVVLFM 327

  Fly   650 LANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDD---IA 711
            ..|..|::..:..::|||:||:|||:|:|||||.:.|||:||||:||||||.|.:||.:|   :.
Mouse   328 CMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVE 392

  Fly   712 GQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIK 776
            .:....|||:|||.|:|||||||||:.|||:||...:|:||||:||||||||||||.||||||||
Mouse   393 DEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIK 457

  Fly   777 LLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVK 841
            :|||||||||||||||.|||||.|||||.||..|..||.....:|:||:|||:|.|.||||||.|
Mouse   458 ILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRK 522

  Fly   842 WQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLI-- 904
            |||||||.||.:||.:||||||||:||:|.||.||:|||.||.|.|.|||.:|:.|.||||||
Mouse   523 WQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQ 587

  Fly   905 -------VPGDIYRPHKKSRNRLQ-----VNGNISKEL--------------------RMMGHGT 937
                   :|.||.:......:|..     ..|:.|.||                    .::.:..
Mouse   588 PEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHL 652

  Fly   938 AQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEP 1002
            ||....:.|          || |:|:.:...||.||.|.||.||.:...|.|||:.||.||:...
Mouse   653 AQALHVQSG----------PE-EINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMR 706

  Fly  1003 DRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKR 1067
            |.:......|:.:|||..:.::.::..|.|:.:.:....|::|...:.|:...:....||..:::
Mouse   707 DEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRK 771

  Fly  1068 FSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTK 1132
            ....|:.......:..|||:.:..|..:|.:               .|.|.:.||.|.:...|:
Mouse   772 TCCWINETYLARNVIIFASILINFLGAVLNI---------------LWCDFDKSIPLKNLTFNS- 820

  Fly  1133 MYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLY------ 1191
              .|...|...|..|  |:...:|:|::||.:..|..:|||.:||:....|...:..:|
Mouse   821 --SAVFTDICSYPEY--FVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLS 881

  Fly  1192 --SRSREMSQELANEEALLRYIIDSIFLFA-FMLALIFHSHQTEATYRLDFIWKLQATEEKEDME 1253
              :.:......|..:||       |:.|.| |:||:.:|..|.|.|.||||:|::||.||..:|:
Mouse   882 YDNLNHSGEDFLGTKEA-------SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMK 939

  Fly  1254 HLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVE 1318
            .|:.:|..:|.||||.|||.|||.:::..::||.:..|:|.::|||||.|::||.:.|.||:|||
Mouse   940 ELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVE 1004

  Fly  1319 CLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT--ANTCDRVNFSHVTAMADYALQL 1381
            ||||||||||||||||.|:||:.|||||:.|:||||.|||:  ...|:. .:.|:.|:||::|.|
Mouse  1005 CLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCED-KWGHLCALADFSLAL 1068

  Fly  1382 FDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQE 1446
            .:.|:|:|.||||||.:||||:.|.||||||||.||||||||..||:||||||||:...|||.:|
Mouse  1069 TESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEE 1133

  Fly  1447 MQQILEGRGFELTCRGSVDVKG----KGSMITYFLKGR---RPIDAKELELAKTEVEPPKTL--- 1501
            ...||:.:||....||.:.|||    :|.:.||||.||   .|.           :.||:.|
Mouse  1134 TYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPF-----------ILPPRRLPGQ 1187

  Fly  1502 -TLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQRRKSLCRQHNIS 1565
             :||.....|                                    :|:|..||:|.|..:::.|
Mouse  1188 YSLAAVVLGL------------------------------------VQSLNRQRQKQLLNENSNS 1216

  Fly  1566 SSFGTTVSSSTGITPS 1581
            ....:..:..|.:|||
Mouse  1217 GIIKSHYNRRTLLTPS 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	56/202 (28%)
		CYCc	686..881	CDD:214485	136/197 (69%)
		Guanylate_cyc	722..895	CDD:278633	124/172 (72%)
		DUF1053	<949..1005	CDD:283888	22/55 (40%)
		CYCc	1259..1455	CDD:214485	115/197 (58%)
		Guanylate_cyc	1285..1479	CDD:278633	115/199 (58%)
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180		48/196 (24%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107		25/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33		5/32 (16%)
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40		1/1 (100%)
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118		14/79 (18%)
		AC_N	<159..398	CDD:292831	96/478 (20%)
		CYCc	364..562	CDD:214485	136/197 (69%)
		Guanylate_cyc	403..587	CDD:278633	132/183 (72%)
		DUF1053	615..709	CDD:283888	29/104 (28%)
		CYCc	942..1146	CDD:214485	117/204 (57%)
		Guanylate_cyc	971..1170	CDD:278633	115/199 (58%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		52/173 (30%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213		6/14 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710