Protein Alignment CG43373 and Adcy7

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1099
• Identity: 390/1099 - (35%)
• Similarity: 572/1099 - (52%)
• Gaps: 195/1099 - (17%)

  Fly   526 VFLIVMLICGIVYAFLLCIL--------SKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKS 582
            :.|:::|:.......|:.|.        .:..:...||:|..:|.|...:.:|..|...:: :.:
Mouse    34 LLLLLLLVAAATCIALISIAFSHEDLRRHQVVLGTAFLMLTLFVALYVLVYVECLVQRWLR-ALA 97

  Fly   583 FNGSACCIVL-------------------------IYMTYTMLPLRLREALIGGILLSVVHL--- 619
            ....||.:||                         :::.|.:|||..|.|::.|:..:|.||
Mouse    98 LLTWACLMVLGSVLMWDSLENEAHAWEQVPFFLFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVF 162

  Fly   620 --YTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLR 682
              .|.....:|....:.:    :||...|.||..|.||.:.....:.|.|..||.|.:||:.|.:
Mouse   163 GAVTRAFQTSMSSTQLGL----QLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRK 223

  Fly   683 TQRENQQQERLLLSVLPRHVAMEMKDDI-----AGQPR----DTQFHKIYIQRHENVSILFADIC 738
            .:.|.:|||.|||||||.|::|.||..|     .|..|    |..||.:|::||:|||||:|||.
Mouse   224 LRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKRHQNVSILYADIV 288

  Fly   739 GFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMG 803
            |||.|:..|:.:|||.:|||||.:||::|..:.|:|||:||||||||||||...|.||...|:||
Mouse   289 GFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMG 353

  Fly   804 LDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHI 868
            ||:.:||..|||...|:::||||||:|.|.|||:||.|||:||||:||:|||.||:.|:||||||
Mouse   354 LDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHI 418

  Fly   869 TKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRM- 932
            |:.||..||..||||.|.|.:|:.|||:..|.|||::.....:|...|.:..:..|:.:.::|.
Mouse   419 TEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLKMRAS 483

  Fly   933 -------------------------------MGHGTAQK------HTSKFGFGDSSESAKDP-ED 959
                                           :.:|..||      |.:.    |.|.|.|.. ||
Mouse   484 VRVTRYLESWGAARPFAHLNHRESVSSSETPISNGRRQKAIPLRRHRAP----DRSASPKGRLED 544

  Fly   960 EVNEYLMRAIDARSIDH---LRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTS 1021
            :.::.::.||:..|...   .:::...:....|.:...||:|...|.......|.|:.||.:...
Mouse   545 DCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCIL 609

  Fly  1022 IMRLVVFQSSLLTLALSTGAL-LLLGFLVFLVACHKINFQ--LPSDIKRFSLRIHSNRRISQLFA 1083
            ::.|:| ...:.||.:|.|.: .|||.:  |..|....|.  .||   |.:|:..|....:|  .
Mouse   610 LVHLLV-MPRMATLGVSFGLVACLLGLV--LSFCFATEFSRCFPS---RSTLQAISESVETQ--P 666

  Fly  1084 FASVALIVLT--TLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEP------- 1139
            ...:.|:|||  :||.:                 ..:|..::||.        ..|:|
Mouse   667 LVRLVLVVLTVGSLLTV-----------------AIINMPLTLNP--------GPEQPGDNKTSP 706

  Fly  1140 ---------DCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYM------AC--- 1186
                     .|:. |.|.|  ...:|..::|:.:..:.:.||.:||.:|..:|:      .|
Mouse   707 LAAQNRVGTPCEL-LPYYT--CSCILGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLSPCWHV 768

  Fly  1187 SSN------------LYSRSREM--------SQELANEEALLR---YIIDSIFLFAFMLALIFHS 1228
            |.|            |.|.::.|        ::|.|...:.|.   .|:.:.:|..|...||..|
Mouse   769 SGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLKIMVNFYLILFYATLILLS 833

  Fly  1229 HQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSV 1293
            .|.:...|||.:||.:..:|.|:.|.::..||.||||:||.|||.||:. :|..:|.||:..|.|
Mouse   834 RQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKAAEDWYHQSYDCV 897

  Fly  1294 CILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGL 1358
            |::|||:|:|..||.|.:.|.||:|||||||||||||||||.:.:|..:||||:.|:|||||:||
Mouse   898 CVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGL 962

  Fly  1359 TA------NTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKP 1417
            :|      ...:|.:. |:..:.::::.|..|::.:|.||||:||:|:|||.|||:||||||.||
Mouse   963 SAPSGHENQDLERKHV-HIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1026

  Fly  1418 QYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYF 1476
            |||||||.|||||||:|||.:..||||:|...||:|.|:...|||.::|||||.:.|||
Mouse  1027 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYF 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	62/240 (26%)
		CYCc	686..881	CDD:214485	117/203 (58%)
		Guanylate_cyc	722..895	CDD:278633	104/172 (60%)
		DUF1053	<949..1005	CDD:283888	14/59 (24%)
		CYCc	1259..1455	CDD:214485	113/201 (56%)
		Guanylate_cyc	1285..1479	CDD:278633	110/198 (56%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	51/180 (28%)
		Guanylate_cyc	272..422	CDD:306677	92/149 (62%)
		DUF1053	487..593	CDD:399378	18/109 (17%)
		Guanylate_cyc	890..1085	CDD:306677	108/195 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810