Protein Alignment CG43373 and ADCY9

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1344
• Identity: 365/1344 - (27%)
• Similarity: 541/1344 - (40%)
• Gaps: 421/1344 - (31%)

  Fly   507 LGYGQLIPLILMQVD-ESVLVFLIVMLICGIV--YAFLLCILSK-----PAMNEIFLVLVSYVIL 563
            :|:..|:..|...|. .|.|:.::...:|.::  ..|.|...:|     .|...:.|.|:.:
Human   123 IGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVF--- 184

  Fly   564 GTFLAIEVAVSYAMQPSKSFNGSA------------C---------CIVLIYMTYTMLPLRLREA 607
                |:.:|..:.:....|..|.:            |         ||.::::.||::.|.|..:
Human   185 ----ALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLS 245

  Fly   608 LIGGILLSVVHLYTCLRLNAMQDEA------VEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQ 666
            |..|:..||  |:.....: .:|||      ...:|||.|...|:...: :..||:.....:...
Human   246 LCLGVAYSV--LFETFGYH-FRDEACFPSPGAGALHWELLSRGLLHGCI-HAIGVHLFVMSQVRS 306

  Fly   667 RKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQ----------------PR 715
            |..|::..|.|......:.|...:||::.||:||.:|    ||:..|                |:
Human   307 RSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIA----DDLMKQGDEESENSVKRHATSSPK 367

  Fly   716 DTQ-----------FHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 769
            :.:           |....:|:.|.||||||||.|||.:|...:|..||.|||:||.|||||..|
Human   368 NRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEE 432

  Fly   770 HHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 834
            ..|.:|..||||||||:|.||||.|||:|.:||||.||.||....:.....||||||:|||.|.|
Human   433 TKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLC 497

  Fly   835 GVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNER--NSYLKDH 897
            |:||:.:::||||||||.|||.||..|:.|:|||::.|.|.||..||:|.||..||  .|.:.|.
Human   498 GILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQ 562

  Fly   898 --QIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRM----------------------MGHGTA 938
              .::||||                  :|..:||.|.                      .|.|||
Human   563 LKGLKTYLI------------------SGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTA 609

  Fly   939 QK-------HTSK------------FGFGDSSESAKD---------------------------- 956
            ..       .|.|            ..|...||:..:
Human   610 SSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSV 674

  Fly   957 ------------------------PEDE--VN------------------------------EYL 965
                                    |::|  .|                              :.:
Human   675 PLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI 739

  Fly   966 MRAIDARSIDHLRAEHCQSLL-------------LCFKDNVLERKY---------ASEPDRMLCV 1008
            ....||..:|.::.:   ||:             |.|.|..|||.|         .:.|.:....
Human   740 REKTDAHFVDVIKED---SLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFAS 801

  Fly  1009 YFYCSLL-VLLGTSIM---------------------RLVVFQSSLLTLALSTG-ALLLLGFLVF 1050
            ..:.||| |.|.|::.                     .|.||.::||...||.. ::.::.||..
Human   802 PTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLED 866

  Fly  1051 LVACHKINFQLPSDIKRFSLRIHSNRRISQLFA-----FASVALIVLTTLLAMFQESGRQMELLQ 1110
            ::||.|                    |:.:..|     ....|::|....||::.....:.|
Human   867 VMACTK--------------------RLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYE--- 908

  Fly  1111 RRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLL 1175
                 .:::..:......|...::            |..|..|:.....|.||......||.|.:
Human   909 -----TNIHFPVFTGSAALIAVVH------------YCNFCQLSSWMRSSLATVVGAGPLLLLYV 956

  Fly  1176 LLLASGSYMA---------------CSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALI 1225
            .|....|.:.               |:|:: .|.......|..:|.:|.:       |..:|.:.
Human   957 SLCPDSSVLTSPLDAVQNFSSERNPCNSSV-PRDLRRPASLIGQEVVLVF-------FLLLLLVW 1013

  Fly  1226 FHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQC 1290
            |.:.:.|.:|||.:...::|...:..::.::.....||.||:|.||||     :..:...|.:..
Human  1014 FLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE-----QLKVSQTYSKNH 1073

  Fly  1291 DSVCILFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMA 1354
            ||..::||||.||||||.| .||   |.||.|:|||:|.|||||||:..:..|||||:.||||||
Human  1074 DSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMA 1135

  Fly  1355 ASGLTANTCDRVNFS----HVTAMADYALQLFDKIEEVNMHS-FNNFRMRIGINIGPVVAGVIGA 1414
            ||||  ||....:.|    |:..:.::|.::...:::.|.:. :.||::|:|.|.||:.|||||.
Human  1136 ASGL--NTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGT 1198

  Fly  1415 CKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLK- 1478
            .|..|||||:.||:|||||:||:...|||::|..::|...|::...||:|:|||||.|.||...
Human  1199 TKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPK 1263

  Fly  1479 --------------------------GRRPID------------------------AKELELAKT 1493
                                      ||.|.|                        ||:..|:
Human  1264 CTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLS-- 1326

  Fly  1494 EVEPPKTLTLAKEPEKLDS----GTATEKQREQVKEQGSTEQED 1533
                ||...  |||.|.:.    |.|.||  :...|.|..|..:
Human  1327 ----PKRPW--KEPVKAEERGRFGKAIEK--DDCDETGIEEANE 1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	51/257 (20%)
		Guanylate_cyc	722..904	CDD:425528	102/185 (55%)
		Adcy_cons_dom	<949..1005	CDD:461877	18/161 (11%)
		Guanylate_cyc	1285..1479	CDD:425528	96/226 (42%)
ADCY9	XP_005255136.1	AcyC	167..576	CDD:441717	151/441 (34%)
		Guanylate_cyc	385..573	CDD:425528	104/205 (51%)
		Guanylate_cyc	1069..1260	CDD:425528	95/195 (49%)