DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43373 and ADCY9

DIOPT Version :9

Sequence 1:NP_001097622.2 Gene:CG43373 / 39835 FlyBaseID:FBgn0263131 Length:1854 Species:Drosophila melanogaster
Sequence 2:XP_005255136.1 Gene:ADCY9 / 115 HGNCID:240 Length:1372 Species:Homo sapiens


Alignment Length:1344 Identity:365/1344 - (27%)
Similarity:541/1344 - (40%) Gaps:421/1344 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   507 LGYGQLIPLILMQVD-ESVLVFLIVMLICGIV--YAFLLCILSK-----PAMNEIFLVLVSYVIL 563
            :|:..|:..|...|. .|.|:.::...:|.::  ..|.|...:|     .|...:.|.|:.:   
Human   123 IGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVF--- 184

  Fly   564 GTFLAIEVAVSYAMQPSKSFNGSA------------C---------CIVLIYMTYTMLPLRLREA 607
                |:.:|..:.:....|..|.:            |         ||.::::.||::.|.|..:
Human   185 ----ALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLS 245

  Fly   608 LIGGILLSVVHLYTCLRLNAMQDEA------VEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQ 666
            |..|:..||  |:.....: .:|||      ...:|||.|...|:...: :..||:.....:...
Human   246 LCLGVAYSV--LFETFGYH-FRDEACFPSPGAGALHWELLSRGLLHGCI-HAIGVHLFVMSQVRS 306

  Fly   667 RKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQ----------------PR 715
            |..|::..|.|......:.|...:||::.||:||.:|    ||:..|                |:
Human   307 RSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIA----DDLMKQGDEESENSVKRHATSSPK 367

  Fly   716 DTQ-----------FHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 769
            :.:           |....:|:.|.||||||||.|||.:|...:|..||.|||:||.|||||..|
Human   368 NRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEE 432

  Fly   770 HHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 834
            ..|.:|..||||||||:|.||||.|||:|.:||||.||.||....:.....||||||:|||.|.|
Human   433 TKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLC 497

  Fly   835 GVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNER--NSYLKDH 897
            |:||:.:::||||||||.|||.||..|:.|:|||::.|.|.||..||:|.||..||  .|.:.|.
Human   498 GILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQ 562

  Fly   898 --QIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRM----------------------MGHGTA 938
              .::||||                  :|..:||.|.                      .|.|||
Human   563 LKGLKTYLI------------------SGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTA 609

  Fly   939 QK-------HTSK------------FGFGDSSESAKD---------------------------- 956
            ..       .|.|            ..|...||:..:                            
Human   610 SSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSV 674

  Fly   957 ------------------------PEDE--VN------------------------------EYL 965
                                    |::|  .|                              :.:
Human   675 PLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI 739

  Fly   966 MRAIDARSIDHLRAEHCQSLL-------------LCFKDNVLERKY---------ASEPDRMLCV 1008
            ....||..:|.::.:   ||:             |.|.|..|||.|         .:.|.:....
Human   740 REKTDAHFVDVIKED---SLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFAS 801

  Fly  1009 YFYCSLL-VLLGTSIM---------------------RLVVFQSSLLTLALSTG-ALLLLGFLVF 1050
            ..:.||| |.|.|::.                     .|.||.::||...||.. ::.::.||..
Human   802 PTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLED 866

  Fly  1051 LVACHKINFQLPSDIKRFSLRIHSNRRISQLFA-----FASVALIVLTTLLAMFQESGRQMELLQ 1110
            ::||.|                    |:.:..|     ....|::|....||::.....:.|   
Human   867 VMACTK--------------------RLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYE--- 908

  Fly  1111 RRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLL 1175
                 .:::..:......|...::            |..|..|:.....|.||......||.|.:
Human   909 -----TNIHFPVFTGSAALIAVVH------------YCNFCQLSSWMRSSLATVVGAGPLLLLYV 956

  Fly  1176 LLLASGSYMA---------------CSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALI 1225
            .|....|.:.               |:|:: .|.......|..:|.:|.:       |..:|.:.
Human   957 SLCPDSSVLTSPLDAVQNFSSERNPCNSSV-PRDLRRPASLIGQEVVLVF-------FLLLLLVW 1013

  Fly  1226 FHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQC 1290
            |.:.:.|.:|||.:...::|...:..::.::.....||.||:|.||||     :..:...|.:..
Human  1014 FLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE-----QLKVSQTYSKNH 1073

  Fly  1291 DSVCILFASIPNFSEFYVE-LEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMA 1354
            ||..::||||.||||||.| .||   |.||.|:|||:|.|||||||:..:..|||||:.||||||
Human  1074 DSGGVIFASIVNFSEFYEENYEG---GKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMA 1135

  Fly  1355 ASGLTANTCDRVNFS----HVTAMADYALQLFDKIEEVNMHS-FNNFRMRIGINIGPVVAGVIGA 1414
            ||||  ||....:.|    |:..:.::|.::...:::.|.:. :.||::|:|.|.||:.|||||.
Human  1136 ASGL--NTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGT 1198

  Fly  1415 CKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLK- 1478
            .|..|||||:.||:|||||:||:...|||::|..::|...|::...||:|:|||||.|.||... 
Human  1199 TKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPK 1263

  Fly  1479 --------------------------GRRPID------------------------AKELELAKT 1493
                                      ||.|.|                        ||:..|:  
Human  1264 CTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLS-- 1326

  Fly  1494 EVEPPKTLTLAKEPEKLDS----GTATEKQREQVKEQGSTEQED 1533
                ||...  |||.|.:.    |.|.||  :...|.|..|..:
Human  1327 ----PKRPW--KEPVKAEERGRFGKAIEK--DDCDETGIEEANE 1362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43373NP_001097622.2 AC_N <523..720 CDD:292831 51/257 (20%)
CYCc 686..881 CDD:214485 104/221 (47%)
Guanylate_cyc 722..895 CDD:278633 99/174 (57%)
DUF1053 <949..1005 CDD:283888 18/161 (11%)
CYCc 1259..1455 CDD:214485 93/201 (46%)
Guanylate_cyc 1285..1479 CDD:278633 96/226 (42%)
ADCY9XP_005255136.1 DUF2339 <118..>301 CDD:287113 39/188 (21%)
CYCc 326..544 CDD:214485 104/221 (47%)
Guanylate_cyc 385..573 CDD:278633 104/205 (51%)
CYCc 1043..1243 CDD:214485 94/209 (45%)
Guanylate_cyc 1069..1260 CDD:278633 95/195 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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