DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43373 and ADCY8

DIOPT Version :10

Sequence 1:NP_001097622.2 Gene:CG43373 / 39835 FlyBaseID:FBgn0263131 Length:1854 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:1600 Identity:508/1600 - (31%)
Similarity:716/1600 - (44%) Gaps:471/1600 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 VGGVVGGSGSHQASMELHVPGQEGRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVV 158
            :.|..|||||..        |..|:.:....|.|                 .|......|..|:.
Human    51 IHGHRGGSGSGS--------GGSGKASDPAGGGP-----------------NHHAPQLSGDSALP 90

  Fly   159 SSSLIAAGITRCNIDESMDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGG--GT 221
            ..||             .....:.|||.:.:..:|..:     |.||        .|||||  |.
Human    91 LYSL-------------GPGERAHSTCGTKVFPERSGS-----GSAS--------GSGGGGDLGF 129

  Fly   222 ANGPVSPSISFWFRLN-----RIILRLCSTHQFKNLQVEMLYQRYFLRMNQS-----NTTHILAL 276
            .:...:||.|.:| ||     |.::.....:.||:..:|.|||||||...:.     |...:|..
Human   130 LHLDCAPSNSDFF-LNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTK 193

  Fly   277 LLALILALSCTLLVFTTLQLRRSTSLLLEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSS 341
            |..|:|.||                                  |.:|.|.|.........| |..
Human   194 LTLLVLHLS----------------------------------LASAPMDPLKGILLGFFT-GIE 223

  Fly   342 IPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQ 406
            :.:.||                                  :|.|:....|               
Human   224 VVICAL----------------------------------VVVRKDTTSH--------------- 239

  Fly   407 QHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHITY 471
                       ..||.:|:|....:.||::                          :||      
Human   240 -----------TYLQYSGVVTWVAMTTQIL--------------------------AAG------ 261

  Fly   472 TPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGI 536
                                               ||||                          
Human   262 -----------------------------------LGYG-------------------------- 265

  Fly   537 VYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLP 601
                                     :||                   :|....:..::.||:|||
Human   266 -------------------------LLG-------------------DGIGYVLFTLFATYSMLP 286

  Fly   602 LRLREALIGGI---LLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKE 663
            |.|..|::.|:   ||.|:......||        .:|...:::...|..:..|..|::..:..:
Human   287 LPLTWAILAGLGTSLLQVILQVVIPRL--------AVISINQVVAQAVLFMCMNTAGIFISYLSD 343

  Fly   664 KAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDD---IAGQPRDTQFHKIYIQ 725
            :|||:||:|||:|:|||||.:.|||:||||:||||||.|.:||.:|   :..:....|||:|||.
Human   344 RAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIH 408

  Fly   726 RHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 790
            |:|||||||||:.|||:||...:|:||||:||||||||||||.||||||||:|||||||||||||
Human   409 RYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPE 473

  Fly   791 PRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLAN 855
            ||.|||||.|||||.||..|..||.....:|:||:|||:|.|.||||||.||||||||.||.:||
Human   474 PRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIAN 538

  Fly   856 HMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLI---------VPGDIYR 911
            .:||||||||:||:|.||.||:|||.||.|.|.|||.:|:.|.||||||         :|.||.:
Human   539 KLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVK 603

  Fly   912 PHKKSRNRLQ-----VNGNISKEL--------------------RMMGHGTAQKHTSKFGFGDSS 951
            ....|.:|..     ..|:.|.||                    .::.:..||....:.|     
Human   604 ESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSG----- 663

  Fly   952 ESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLV 1016
                 || |:|:.:...||.||.|.||.||.:...|.|||:.||.||:...|.:......|:.:|
Human   664 -----PE-EINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV 722

  Fly  1017 LLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQL 1081
            ||..:.::.::..|.::.:.:....|::|...:.|:...:....||..:::....|:.......:
Human   723 LLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNV 787

  Fly  1082 FAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLA 1146
            ..|||:.:..|..:|.:               .|.|.:.||.|.:...|:   .|...|...|..
Human   788 IIFASILINFLGAILNI---------------LWCDFDKSIPLKNLTFNS---SAVFTDICSYPE 834

  Fly  1147 YNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYS----RSREMSQELANEEAL 1207
            |  |:...:|:|::||.:..|..:|||.:||:....|...:..:|:    |...::.  :.|:.|
Human   835 Y--FVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNH--SGEDFL 895

  Fly  1208 LRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVA 1272
            ....:..:.:..|:||:.:|..|.|.|.||||:|::||.||..:|:.|:.:|..:|.||||.|||
Human   896 GTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA 960

  Fly  1273 EHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEE 1337
            .|||.:::..::||.:..|:|.::|||||.|::||.:.|.||:|||||||||||||||||||.|:
Human   961 RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGED 1025

  Fly  1338 RFRCIEKIKSTGATYMAASGLT--ANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRI 1400
            ||:.|||||:.|:||||.|||:  ...|:. .:.|:.|:||::|.|.:.|:|:|.||||||.:||
Human  1026 RFQDIEKIKTIGSTYMAVSGLSPEKQQCED-KWGHLCALADFSLALTESIQEINKHSFNNFELRI 1089

  Fly  1401 GINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVD 1465
            ||:.|.||||||||.||||||||..||:||||||||:...|||.:|...||:.:||....||.:.
Human  1090 GISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY 1154

  Fly  1466 VKG----KGSMITYFLKGR---RPIDAKELELAKTEVEPPKTL----TLAKEPEKLDSGTATEKQ 1519
            |||    :|.:.||||.||   .|.           :.||:.|    :||.....|         
Human  1155 VKGISEQEGKIKTYFLLGRVQPNPF-----------ILPPRRLPGQYSLAAVVLGL--------- 1199

  Fly  1520 REQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQRRKSLCRQHNISSSFGTTVSSSTGITPSISN 1584
                                       :|:|..||:|.|..::|           :|||.....|
Human  1200 ---------------------------VQSLNRQRQKQLLNENN-----------NTGIIKGHYN 1226

  Fly  1585 SSSVVTIGALPAILRGGNPLSNANPNATDSCSECGGASKS 1624
            ..:::                  :|:.|:..::..|..||
Human  1227 RRTLL------------------SPSGTEPGAQAEGTDKS 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43373NP_001097622.2 AC_N <523..720 CDD:318454 53/202 (26%)
Guanylate_cyc 722..904 CDD:425528 130/181 (72%)
Adcy_cons_dom <949..1005 CDD:461877 22/55 (40%)
Guanylate_cyc 1285..1479 CDD:425528 115/199 (58%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182 45/182 (25%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109 18/95 (19%)
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51 507/1599 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92 13/65 (20%)
AcyC 214..567 CDD:441717 192/558 (34%)
Guanylate_cyc 405..589 CDD:425528 132/183 (72%)
Adcy_cons_dom 617..712 CDD:461877 29/105 (28%)
Guanylate_cyc 973..1172 CDD:425528 115/199 (58%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 56/215 (26%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215 6/14 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251 5/43 (12%)
Blue background indicates that the domain is not in the aligned region.

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