Protein Alignment CG43373 and ADCY6

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_056085.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1443
• Identity: 549/1443 - (38%)
• Similarity: 728/1443 - (50%)
• Gaps: 390/1443 - (27%)

  Fly   118 RGTSSGA------------GSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAAGITRC 170
            |||.:|.            ..|.:.| |:.|.:..|:..........|....:....:|.|
Human    31 RGTRAGGFCTPRYMSCLRDAEPPSPT-PAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG---- 90

  Fly   171 NIDESMDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSI----- 230
                 .:.|..::|                                 .||||.  |:|..
Human    91 -----FEDTEVTTT---------------------------------AGGTAE--VAPDAVPRSG 115

  Fly   231 -SFWFRLNRIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFTTL 294
             |.|.||    :::..:.||::.::|.||||||.:||||:    |.||:|:::.|:..||.|
Human   116 RSCWRRL----VQVFQSKQFRSAKLERLYQRYFFQMNQSS----LTLLMAVLVLLTAVLLAF--- 169

  Fly   295 QLRRSTSLLLEISEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAV 359
                                    :...|..:|..:|            |||.|:
Human   170 ------------------------HAAPARPQPAYVA------------LLACAA---------- 188

  Fly   360 GGELKSAHNHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAG 424
                                                                             
Human   189 ----------------------------------------------------------------- 188

  Fly   425 LVKGGGIQTQLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEV 489
                                                                             
Human   189 ----------------------------------------------------------------- 188

  Fly   490 LNTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIF 554
                                               .:|:.:|::|           ::.:..:..
Human   189 -----------------------------------ALFVGLMVVC-----------NRHSFRQDS 207

  Fly   555 LVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHL 619
            :.:||||:||...|::|..:.|..|.....|..|.:..:|:.||:||:|:|.|::.|:.||.:||
Human   208 MWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHL 272

  Fly   620 YTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQ 684
            ....:||     ..:...|::|...::..|..|:.|:.||:|.|.:||:||.|||..|:|||..|
Human   273 ILAWQLN-----RGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQ 332

  Fly   685 RENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTA 749
            .||:|||||||||||:|||||||:||..:..|..|||||||:|:|||||||||.|||||:.||||
Human   333 HENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTA 397

  Fly   750 EELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVR 814
            :|||..|||||||||:||||:||||||:|||||||||||||.|.|||||.||||:|||:||:|||
Human   398 QELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVR 462

  Fly   815 EVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGD 879
            ||..||||||||||:||||||||||.||||||||||||||||||:||..||:|||:.||:.|:||
Human   463 EVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGD 527

  Fly   880 YEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSR----NRLQVNG---------------- 924
            ||||.|:|.|||:|||:..|||:||:.....|..:|:.    .|.:.|.
Human   528 YEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR 592

  Fly   925 -NISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLC 988
             ..||..|.||...:.|...      .::.|.:|||||:|:|.|||||||||.||.:|.:..||.
Human   593 TKDSKAFRQMGIDDSSKDNR------GTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLT 651

  Fly   989 FKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVA 1053
            |:...||:||:.:.|.....|..|:|||......::|::|..|.|.|.:.....|||...|.:.|
Human   652 FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICA 716

  Fly  1054 CHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMF--------QESGRQMEL-- 1108
            .:......|..::|.|..|..:|..|......||.|:..:.:..||        ..:.|.:.|
Human   717 VYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTP 781

  Fly  1109 -------LQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDF--YLAYNTFLLLTLL-------- 1156
                   ||:..:.|.           |:..:.:...|.|.|  |...|  :||:||
Human   782 ADITACHLQQLNYSLG-----------LDAPLCEGTMPTCSFPEYFIGN--MLLSLLASSVFLHI 833

  Fly  1157 -SMMSCATYQVLRILLKLLLLL-----------LASGSYMACSSNLYSRSREMSQEL---ANEEA 1206
             |:...|...||.::..:||||           |..|.:...|||      |....|   |....
Human   834 SSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSN------ETFDGLDCPAAGRV 892

  Fly  1207 LLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHV 1271
            .|:| :..:.|..|.|||..|:.|.|:|.||||:||||||.|||:||.||||||:||.||||..|
Human   893 ALKY-MTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDV 956

  Fly  1272 AEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSE 1336
            |.|||:||:..|:||::.|:.|.::||||.||||||||||.||||||||||||||||||||::||
Human   957 AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1021

  Fly  1337 ERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIG 1401
            ||||.:||||:.|:||||||||.|:|.|:|..||:||:||||::|.::::.:|.||||||:|:||
Human  1022 ERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIG 1086

  Fly  1402 INIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDV 1466
            :|:||||||||||.|||||||||.|||:|||||||:.|.||||.::.|:|..:|::|.|||.|.|
Human  1087 LNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKV 1151

  Fly  1467 KGKGSMITYFLKG 1479
            ||||.|.||||.|
Human  1152 KGKGEMTTYFLNG 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	74/196 (38%)
		Guanylate_cyc	722..904	CDD:425528	143/181 (79%)
		Adcy_cons_dom	<949..1005	CDD:461877	28/55 (51%)
		Guanylate_cyc	1285..1479	CDD:425528	133/193 (69%)
ADCY6	NP_056085.1	AC_N	<16..368	CDD:318454	126/619 (20%)
		Guanylate_cyc	370..554	CDD:425528	145/183 (79%)
		Adcy_cons_dom	582..669	CDD:461877	34/92 (37%)
		Guanylate_cyc	970..1164	CDD:425528	133/193 (69%)