DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and ADCY3

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_011530791.1	Gene:	ADCY3 / 109	HGNCID:	234	Length:	1186	Species:	Homo sapiens

Alignment Length:	1214	Identity:	393/1214 - (32%)
Similarity:	607/1214 - (50%)	Gaps:	250/1214 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 YTVASDDDDDVDGG-------RSAGS-------KHITYTPRVRD--YNQISHAERDEVLNTSSNA 496
            |:|:...|.|...|       |::||       ..:|:.|...:  |......:|.|.|
Human    20 YSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETL------ 78

  Fly   497 GVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYA-----------------FLLCI 544
                                |:.|..:.|....|:::|.:|::                 .:|.:
Human    79 --------------------LVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFV 123

  Fly   545 LSKPAM--NEIFLVLVSYVI-------LGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTML 600
            |.|..:  :.:...::.||:       :.::|.:..|.::|...:..:.     :..::..:..|
Human   124 LCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQ-----VFFVFSFFITL 183

  Fly   601 PLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWE---ELLCTLVALLLANLTGVYTHWPK 662
            ||.|...:|..::..|||... |.:...|.:..|:...:   |:|..:...|.|...|:.:::..
Human   184 PLSLSPIVIISVVSCVVHTLV-LGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMA 247

  Fly   663 EKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDI---AGQPRDTQFHKIYI 724
            ::..||||:|.||.:|.::..:.::||||.|:||:||:|||.||..|:   ..|....||:.:|:
Human   248 DRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYM 312

  Fly   725 QRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 789
            .||||||||||||.|||.||..|:|:|||:||||||||||:|||::|.||||:|||||||:.|||
Human   313 YRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLP 377

  Fly   790 EPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLA 854
            :.|.|||.|::.|||.|::||:.|||.....|:||||:|||.|..||||..:||:||||.|||:|
Human   378 DYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVA 442

  Fly   855 NHMESGGIPG----------------------RVHITKETLKCLDGDYEVEVGKGNERNSYLKDH 897
            |.||:|||||                      ||||::.|:.||.|:::||.|.|..|..||::.
Human   443 NKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEK 507

  Fly   898 QIETYLIVPGDIYRPH-KKSRNRLQVNGNI--------SKELRMMGHGTAQKHTSKFGFGDSSE- 952
            .||||||:..   :|. ||:..:..:||:.        ||........|.:.:.|....|.:||
Human   508 GIETYLIIAS---KPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEK 569

  Fly   953 -------------------------------------------------SAKDPEDEVNEYLMRA 968
                                                             .|.:.|.|:|:.|..|
Human   570 PEEQDAQLFPTTLSHLPHSRCLPGSQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEA 634

  Fly   969 -IDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSL 1032
             ::..|...::..:...|.:.|.|..:|.:|:.|.::.....|.||.:|||.|:::.::: ...|
Human   635 LLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILI-DPWL 698

  Fly  1033 LT--LALSTGALLLLGFLVFLVACHKINF---QLPSDIKRFSLRIHSNRRISQLFAFASVALIVL 1092
            :|  :....|.:|||    .|..|.....   ..|..:..||..|...|.....:|..::.::|:
Human   699 MTNYVTFMVGEILLL----ILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVM 759

  Fly  1093 TTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTE---LNTKMYDAEEPDCDFYLAYNTFLLLT 1154
            ..:          :::|...:::...:.:.:..:||   |....|            ||...:|:
Human   760 ANV----------VDMLSCLQYYTGPSNATAGMETEGSCLENPKY------------YNYVAVLS 802

  Fly  1155 LLSMMSCATYQVLRI--LLKLLLLLLASGSYMACSSNLYS-----------RSREMSQELANEEA 1206
            |:     ||..::::  ::||.|:||.:|:  ..:.|||:           |.||....:...|.
Human   803 LI-----ATIMLVQVSHMVKLTLMLLVAGA--VATINLYAWRPVFDEYDHKRFREHDLPMVALEQ 860

  Fly  1207 LLRY------------IIDS-----IFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEH 1254
            :..:            ::.|     :.:|..||:..:.|...|...|..|:||::..::||.:..
Human   861 MQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYE 925

  Fly  1255 LQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVEC 1319
            ::.:|..|:.|:||.|||.|||..:|..::||.:..|.:.::|||:|||::||.|...||.|:||
Human   926 MRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIEC 990

  Fly  1320 LRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT--ANT-----------CDRVNFSHV 1371
            ||.|||||:|||.||...:||.|.|||:.|:|||||||:|  .||           .:|..:.|:
Human   991 LRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHL 1055

  Fly  1372 TAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTG 1436
            ..:||:||.:.|.:..:|..|||||.:|||:|.|.|:||||||.||.||||||.|||||||:|||
Human  1056 ADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTG 1120

  Fly  1437 LVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGR 1480
            ::.:|||.:|.|.||...||....||.:.|||||.::|:|||||
Human  1121 VMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGR 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	53/228 (23%)
		CYCc	686..881	CDD:214485	122/219 (56%)
		Guanylate_cyc	722..895	CDD:278633	110/194 (57%)
		DUF1053	<949..1005	CDD:283888	15/106 (14%)
		CYCc	1259..1455	CDD:214485	108/208 (52%)
		Guanylate_cyc	1285..1479	CDD:278633	108/206 (52%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	62/290 (21%)
		CYCc	273..490	CDD:214485	122/216 (56%)
		Guanylate_cyc	310..516	CDD:278633	117/205 (57%)
		CYCc	925..1143	CDD:214485	110/217 (51%)
		Guanylate_cyc	956..1163	CDD:278633	108/206 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710