Protein Alignment CG43373 and Adcy3

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_612178.2
• Gene: Adcy3 / 104111
• MGIID: 99675
• Length: 1145
• Species: Mus musculus
• Alignment Length: 1175
• Identity: 397/1175 - (33%)
• Similarity: 605/1175 - (51%)
• Gaps: 208/1175 - (17%)

  Fly   448 YTVASDDDDDVDGG-------RSAGS-------KHITYTPRVRD--YNQISHAERDEVLNTSSNA 496
            |:|:...|.|...|       |::||       ..:|:.|...:  |......:|.|.|
Mouse    20 YSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETL------ 78

  Fly   497 GVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYA--------------------FL 541
                                |:.|..:.|....|:::|.:|::                    |:
Mouse    79 --------------------LVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGFGLVLDIILFV 123

  Fly   542 LC-------ILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTM 599
            ||       .:|:..:..:..:|:|..|. ::|.:..:.::|...:..:..     ..::..:..
Mouse   124 LCKKGLLPDRVSRKVVPYLLWLLISAQIF-SYLGLNFSRAHAASDTVGWQA-----FFVFSFFIT 182

  Fly   600 LPLRLREALIGGILLSVVHLYTCLRLNA-----MQDEAVEMIHWEELLCTLVALLLANLTGVYTH 659
            |||.|...:|..::..|||   .|.|..     .|||...|....|:|..:...|.|.:.|:.::
Mouse   183 LPLSLSPIVIISVVSCVVH---TLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSY 244

  Fly   660 WPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDI---AGQPRDTQFHK 721
            :..::..||||:|.||.:|.::..:.::||||.|:||:||:|||.||..|:   ..|....||:.
Mouse   245 YMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNT 309

  Fly   722 IYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 786
            :|:.||||||||||||.|||.||..|:|:|||:||||||||||:|||::|.||||:|||||||:.
Mouse   310 MYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCIC 374

  Fly   787 GLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDV 851
            |||:.|.|||.|::.|||.|::||:.|||.....|:||||:|||.|..||||..:||:||||.||
Mouse   375 GLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDV 439

  Fly   852 TLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKS 916
            |:||.||:|||||||||::.|:.||.|:::||.|.|..|..||.:..||||||:..   :|..|.
Mouse   440 TVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIAS---KPEVKK 501

  Fly   917 RNRLQVNGNI--------SKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDE------------- 960
            ..:..:||:.        ||........|.:.:.|....|.:||.|::.|.:
Mouse   502 TAQNGLNGSAVPNGAPASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRL 566

  Fly   961 -VNEYLMRAIDARSIDH----------LRAEHCQ--------SLLLCFKDNVLERKYASEPDRML 1006
             :.:...|.:||...:|          |..|..|        .|.:.|.|..:|.:|:.|.::..
Mouse   567 RLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQS 631

  Fly  1007 CVYFYCSLLVLLGTSIMRLVV---FQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRF 1068
            ...|.||.:||..|:::.:::   ..::.:|..:.. .|||:..:..:.|....:|  |..:..|
Mouse   632 GAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGE-VLLLILTICSMAAIFPRSF--PKKLVAF 693

  Fly  1069 SLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKM 1133
            |..|...|.....:|..::.::|:..::.|       :..||......::...:.|:...:....
Mouse   694 SSWIDRTRWARNTWAMLAIFILVMANVVDM-------LSCLQYYMGPYNMTAGMELDGGCMENPK 751

  Fly  1134 YDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRI--LLKLLLLLLASGSYMACSSNLYS---- 1192
            |            ||...:|:|:     ||..::::  ::||.|:||.:|:..|.  |||:
Mouse   752 Y------------YNYVAVLSLI-----ATIMLVQVSHMVKLTLMLLVTGAVTAL--NLYAWCPV 797

  Fly  1193 -------RSREMSQELANEEAL-------------------LRYIIDSIFLFAFMLALIFHSHQT 1231
                   |.:|....:...|.:                   .:|.: ::.:|..||:..:.|...
Mouse   798 FDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSM-TVMMFVMMLSFYYFSRHV 861

  Fly  1232 EATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCIL 1296
            |...|..|:||::..::||.:..::.:|..|:.|:||.|||.|||..:|..::||.:..|.:.::
Mouse   862 EKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVM 926

  Fly  1297 FASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT-- 1359
            |||:|||::||.|...||.|:||||.|||||:|||.||...:||.|.|||:.|:|||||||:|
Mouse   927 FASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD 991

  Fly  1360 ANT-----------CDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIG 1413
            .||           .|:..:.|:..:||:||.:.|.:..:|..|||||.:|||:|.|.|:|||||
Mouse   992 VNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIG 1056

  Fly  1414 ACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLK 1478
            |.||.||||||.|||||||:|||::.:|||.:|.|.||...||....||.:.|||||.::|:|||
Mouse  1057 ARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLK 1121

  Fly  1479 GR-RP 1482
            || ||
Mouse  1122 GRDRP 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	57/231 (25%)
		Guanylate_cyc	722..904	CDD:425528	115/181 (64%)
		Adcy_cons_dom	<949..1005	CDD:461877	17/87 (20%)
		Guanylate_cyc	1285..1479	CDD:425528	108/206 (52%)
Adcy3	NP_612178.2	AcyC	105..499	CDD:441717	172/405 (42%)
		Guanylate_cyc	310..494	CDD:425528	117/183 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..564		11/59 (19%)
		Guanylate_cyc	915..1122	CDD:425528	108/206 (52%)