DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy3

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1175	Identity:	397/1175 - (33%)
Similarity:	605/1175 - (51%)	Gaps:	208/1175 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 YTVASDDDDDVDGG-------RSAGS-------KHITYTPRVRD--YNQISHAERDEVLNTSSNA 496
            |:|:...|.|...|       |::||       ..:|:.|...:  |......:|.|.|
Mouse    20 YSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETL------ 78

  Fly   497 GVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYA--------------------FL 541
                                |:.|..:.|....|:::|.:|::                    |:
Mouse    79 --------------------LVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGFGLVLDIILFV 123

  Fly   542 LC-------ILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTM 599
            ||       .:|:..:..:..:|:|..|. ::|.:..:.::|...:..:..     ..::..:..
Mouse   124 LCKKGLLPDRVSRKVVPYLLWLLISAQIF-SYLGLNFSRAHAASDTVGWQA-----FFVFSFFIT 182

  Fly   600 LPLRLREALIGGILLSVVHLYTCLRLNA-----MQDEAVEMIHWEELLCTLVALLLANLTGVYTH 659
            |||.|...:|..::..|||   .|.|..     .|||...|....|:|..:...|.|.:.|:.::
Mouse   183 LPLSLSPIVIISVVSCVVH---TLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSY 244

  Fly   660 WPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDI---AGQPRDTQFHK 721
            :..::..||||:|.||.:|.::..:.::||||.|:||:||:|||.||..|:   ..|....||:.
Mouse   245 YMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNT 309

  Fly   722 IYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 786
            :|:.||||||||||||.|||.||..|:|:|||:||||||||||:|||::|.||||:|||||||:.
Mouse   310 MYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCIC 374

  Fly   787 GLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDV 851
            |||:.|.|||.|::.|||.|::||:.|||.....|:||||:|||.|..||||..:||:||||.||
Mouse   375 GLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDV 439

  Fly   852 TLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKS 916
            |:||.||:|||||||||::.|:.||.|:::||.|.|..|..||.:..||||||:..   :|..|.
Mouse   440 TVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIAS---KPEVKK 501

  Fly   917 RNRLQVNGNI--------SKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDE------------- 960
            ..:..:||:.        ||........|.:.:.|....|.:||.|::.|.:
Mouse   502 TAQNGLNGSAVPNGAPASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRL 566

  Fly   961 -VNEYLMRAIDARSIDH----------LRAEHCQ--------SLLLCFKDNVLERKYASEPDRML 1006
             :.:...|.:||...:|          |..|..|        .|.:.|.|..:|.:|:.|.::..
Mouse   567 RLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQS 631

  Fly  1007 CVYFYCSLLVLLGTSIMRLVV---FQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRF 1068
            ...|.||.:||..|:::.:::   ..::.:|..:.. .|||:..:..:.|....:|  |..:..|
Mouse   632 GAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGE-VLLLILTICSMAAIFPRSF--PKKLVAF 693

  Fly  1069 SLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKM 1133
            |..|...|.....:|..::.::|:..::.|       :..||......::...:.|:...:....
Mouse   694 SSWIDRTRWARNTWAMLAIFILVMANVVDM-------LSCLQYYMGPYNMTAGMELDGGCMENPK 751

  Fly  1134 YDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRI--LLKLLLLLLASGSYMACSSNLYS---- 1192
            |            ||...:|:|:     ||..::::  ::||.|:||.:|:..|.  |||:
Mouse   752 Y------------YNYVAVLSLI-----ATIMLVQVSHMVKLTLMLLVTGAVTAL--NLYAWCPV 797

  Fly  1193 -------RSREMSQELANEEAL-------------------LRYIIDSIFLFAFMLALIFHSHQT 1231
                   |.:|....:...|.:                   .:|.: ::.:|..||:..:.|...
Mouse   798 FDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSM-TVMMFVMMLSFYYFSRHV 861

  Fly  1232 EATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCIL 1296
            |...|..|:||::..::||.:..::.:|..|:.|:||.|||.|||..:|..::||.:..|.:.::
Mouse   862 EKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVM 926

  Fly  1297 FASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT-- 1359
            |||:|||::||.|...||.|:||||.|||||:|||.||...:||.|.|||:.|:|||||||:|
Mouse   927 FASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD 991

  Fly  1360 ANT-----------CDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIG 1413
            .||           .|:..:.|:..:||:||.:.|.:..:|..|||||.:|||:|.|.|:|||||
Mouse   992 VNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIG 1056

  Fly  1414 ACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLK 1478
            |.||.||||||.|||||||:|||::.:|||.:|.|.||...||....||.:.|||||.::|:|||
Mouse  1057 ARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLK 1121

  Fly  1479 GR-RP 1482
            || ||
Mouse  1122 GRDRP 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	57/231 (25%)
		CYCc	686..881	CDD:214485	122/197 (62%)
		Guanylate_cyc	722..895	CDD:278633	110/172 (64%)
		DUF1053	<949..1005	CDD:283888	17/87 (20%)
		CYCc	1259..1455	CDD:214485	108/208 (52%)
		Guanylate_cyc	1285..1479	CDD:278633	108/206 (52%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	66/293 (23%)
		Guanylate_cyc	310..494	CDD:306677	117/183 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		11/59 (19%)
		Guanylate_cyc	915..1122	CDD:306677	108/206 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710