Protein Alignment CG43373 and Adcy4

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_001348533.1
• Gene: Adcy4 / 104110
• MGIID: 99674
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1071
• Identity: 385/1071 - (35%)
• Similarity: 556/1071 - (51%)
• Gaps: 152/1071 - (14%)

  Fly   524 VLVFLIVMLICGIV-----------------------------YAFLLCILSKPAMNEIFLVLVS 559
            :|:.|:|:::|.:|                             ::.||.:.|:....:.:...:|
Mouse    29 LLILLLVIVLCALVALPAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQQLQRWTRPLS 93

  Fly   560 YVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLR 624
            .:|....||:.....:......:::..:..:.:|:..|.||||.:|:|...|::.|:.||.....
Mouse    94 GLIWVALLALGYGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGL 158

  Fly   625 LNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQ 689
            ....|.|:...: ..:|....|..|..|:.|.|.....|:|.|..|.|....:.:|.|...|.:.
Mouse   159 YLGWQPESQRAL-LPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLHSRRRLDTEKKH 222

  Fly   690 QERLLLSVLPRHVAMEMKDDI-----AGQ---PRDT-QFHKIYIQRHENVSILFADICGFTSLSD 745
            ||.||||:||.::|.|||.:|     |||   |.:| .||.:|::||:.||:|:|||.|||.|:.
Mouse   223 QEHLLLSILPAYLAREMKAEIMARLQAGQRSRPENTNNFHSLYVKRHQGVSVLYADIVGFTRLAS 287

  Fly   746 QCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAI 810
            :|:.:|||.:|||||.:||::|.||.|:|||:||||||||||||...||||...|.|||||..||
Mouse   288 ECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAI 352

  Fly   811 ALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKC 875
            ..:|....|::|||||:|:|.|.|||:||.|||:||||:|||||||||:||:|||||||..||..
Mouse   353 RKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLAL 417

  Fly   876 LDGDYEVEVGKGNERNSYLKDHQIETYLIV--------------------PGDIYRPHKKSRNRL 920
            |.|.|.||......|:.||::....|||::                    .|...||.......|
Mouse   418 LAGAYAVERADTEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAKGLLSSLEGHTMRPSLLMTRYL 482

  Fly   921 QVNGNISKELRMMGHGTAQKHTS----KFGFG-----DSSESAKDPEDEVNEYLMRAIDARSIDH 976
            :..| .:|....:.|..:...||    :..|.     |.|.:.:..:||::     ..||:....
Mouse   483 ESWG-AAKPFAHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELD-----TGDAKFFQV 541

  Fly   977 LRAEHCQS----------LLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGT-SIMRLVVFQS 1030
            :...:.|.          |.|.|::..:|::|..........|..|:.||.|.. :|..||..:.
Mouse   542 IEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRP 606

  Fly  1031 SLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAF---------AS 1086
            ..|.:..|...||   |.:.|..|  .:..|...:::....:|....:|.|.|.         .:
Mouse   607 PALIITYSITFLL---FFLLLFVC--FSEHLTKCVQKGPKMLHWLPALSVLVATRPGFRVALGTA 666

  Fly  1087 VALIVLTTLLA-----------MFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPD 1140
            ..|:|.|..:|           :|..|  .:..:.....| ::.||:.|....|.:..|...
Mouse   667 TILLVFTMAIASLLFLPVSSDCLFLAS--NVSSVTFNASW-EMPGSLPLISIPLISIPYSMH--- 725

  Fly  1141 CDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLL---ASGSYMACS---------SNLYSR 1193
            |            .:|..:||:.:..:...||||||||   ||.|....|         :.||..
Mouse   726 C------------CVLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSDCLIARLYQS 778

  Fly  1194 SREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAY 1258
            ..:....:..|..|:    .:|:.|.|...|:..:.|.|...||||:||.:..:|:|:.|.::..
Mouse   779 PSDSRPGVLKEPKLM----GAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENL 839

  Fly  1259 NRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLL 1323
            .|.||||:||.|||..|:.:.:..:||||:..:.||:||||:|:|.|||.|...|:||:||||||
Mouse   840 TRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLL 904

  Fly  1324 NEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANT-------CDRVNFSHVTAMADYALQL 1381
            ||||||||||||:.:|..:||||:.|:|||||:||.|.:       .:| :.||:..|.::|:.|
Mouse   905 NEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDTQQDSER-SCSHLGTMVEFAVAL 968

  Fly  1382 FDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQE 1446
            ..|:..:|.|||||||:|:|:|.||||||||||.|||||||||.|||||||:|||::..||||:|
Mouse   969 GSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEE 1033

  Fly  1447 MQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ..:.|:..|:....|||:.|||||.:.||||
Mouse  1034 TARALQSLGYTCYSRGSIKVKGKGELCTYFL 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	58/233 (25%)
		CYCc	686..881	CDD:214485	120/203 (59%)
		Guanylate_cyc	722..895	CDD:278633	104/172 (60%)
		DUF1053	<949..1005	CDD:283888	12/65 (18%)
		CYCc	1259..1455	CDD:214485	115/202 (57%)
		Guanylate_cyc	1285..1479	CDD:278633	116/200 (58%)
Adcy4	NP_001348533.1	AC_N	<115..246	CDD:318454	41/131 (31%)
		Guanylate_cyc	264..418	CDD:306677	97/153 (63%)
		DUF1053	479..580	CDD:368844	19/106 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..524		5/21 (24%)
		Guanylate_cyc	866..1065	CDD:306677	116/200 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810