Protein Alignment CG43373 and adcy4

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1107
• Identity: 401/1107 - (36%)
• Similarity: 585/1107 - (52%)
• Gaps: 182/1107 - (16%)

  Fly   501 DNSDPPLGY------------------GQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSK 547
            :||...||:                  .|..|:||       |:.|||:.:|..:..........
 Frog     3 ENSQTQLGHYRQRCEKEGPLYETYYRLTQQYPVIL-------LLLLIVLAVCCALIIITFATGRT 60

  Fly   548 PAMNEIFLVLVSYVILGTF--LAIEVAVSYAMQPSKSFNG---SACCIVL--------------- 592
            .:.|..|||.: :..||.|  |.|.|.:...:|......|   ..|.:.|
 Frog    61 FSDNVGFLVTL-FCALGVFSILFIPVCIKKVVQKCMQIIGVVILGCLVTLGYVFIFTSGLVSAWD 124

  Fly   593 -IYMT-------YTMLPLRLREALIGGILLSVVHL------YTCLRLNAMQDEAVEMIHWEELLC 643
             ||.|       ||||||.::.|:..|:...|.|:      .:.:||....|.|::||      .
 Frog   125 QIYWTLFVIISLYTMLPLGMKWAIFAGLSCFVAHIIVLSVYVSTVRLLPRDDVALQMI------A 183

  Fly   644 TLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKD 708
            ..|.||..|:.|.|.....|.|.:..:.|....|.:||:...:.:||||||||:||.::|.|||.
 Frog   184 DAVILLCGNVIGGYHKCVTESALKDTYHEAINFIHSRLKLVSQERQQERLLLSILPAYIATEMKA 248

  Fly   709 DI-------AGQPRDT-QFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDR 765
            :|       ..||.:| .||.:||:||::||||:|||.|||.||.:|:.:|||.:|||||.:||:
 Frog   249 EIIERLKEKRPQPENTNNFHNLYIKRHKDVSILYADIVGFTLLSSECSPKELVLMLNELFGKFDQ 313

  Fly   766 LAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTG 830
            :|.::.|:|||:|||||||||||||..|:||...|.|||||..||..:|:...|::|||||:|:|
 Frog   314 IAKDNECMRIKILGDCYYCVSGLPEFLPNHAKNCVLMGLDMCQAIRKLRKATGVDINMRVGVHSG 378

  Fly   831 RVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLK 895
            .|.|||:||.|||:||||:|||||||||:||:|||||||:.||..|:.:||||.....:|:.|||
 Frog   379 NVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITEATLSHLENEYEVEDATLAQRDLYLK 443

  Fly   896 DHQIETYLIV--------PGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDS-- 950
            ::.|:|||::        ..||.........:::.:..:::.|...|   |:|..:.....||
 Frog   444 ENNIKTYLVIDPRANDGEAEDILPSKSAEVPKMRASVRMTRYLESWG---AEKPFAHLSHRDSLV 505

  Fly   951 -------------------------SESAKDPEDEVNE---YLMRAIDARSIDHLRAEHCQSLLL 987
                                     |.|.::..:.:|:   ::|..: |......|::....:.|
 Frog   506 PEPHSISHSMDLPMSPLSQTWSQEKSRSTRETNESLNDNNFHIMEVL-ASQRQWKRSKDFNRITL 569

  Fly   988 CFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSL---LTLALSTGALLLLGFLV 1049
            .|.|...|::|..........|..|...:.....|::::|...:.   ::..:|....|||.|..
 Frog   570 YFNDKAAEKEYRLSDLPSFKYYTACCFFIFACNFIVQILVSHKNAAFGISYGISFFFFLLLLFTC 634

  Fly  1050 F---LVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTL----LAMFQESGRQME 1107
            |   |..|.....||...:...|:.:.|.       .:..|.|.|.|.|    :|:|
 Frog   635 FAGHLARCILKGPQLLHWLPSLSIALSSR-------PWLRVPLGVFTILTVLVMAVF-------- 684

  Fly  1108 LLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLK 1172
                ..|:|..|   :......|:.:....||...:.|.|  ::...:|.:::|:.:.::....|
 Frog   685 ----NLFFLPDN---NCPQQSWNSSLSPDPEPQMLYSLPY--YMYCCILGLLACSAFLLMNFEAK 740

  Fly  1173 LLLLLLA----------SGSYMA-CSSN-LY-SRSREMSQELANEEALLR--YIIDSIFLFAFML 1222
            |:||.:|          :.|::: |..| || :.||         ..:|:  .::.||.||.|..
 Frog   741 LILLSIALVIYNVIFLETHSWLSDCYVNWLYMNHSR---------PGILKEPKVMGSISLFIFFF 796

  Fly  1223 ALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYH 1287
            .|:..|.|.|...||||:||.:...|:|.:|.::..||.||||:||..||:.|:.:.:..:|||:
 Frog   797 TLLALSRQNEYYCRLDFLWKRKFKMERERIETMENLNRVLLENVLPADVAQQFIGQNRRNEDLYY 861

  Fly  1288 EQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATY 1352
            :..|.||:||||||:|.|||.|.:.|:||:||||||||||||||||||:.:|..:||||:.|:.|
 Frog   862 QSYDCVCVLFASIPDFKEFYTECDENHEGLECLRLLNEIIADFDELLSKPKFSSVEKIKTIGSAY 926

  Fly  1353 MAASGLTANT-------CDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAG 1410
            |||:||.|.:       .|| |::|:..|.::|:.|..|::.:|.||||||::|:|||.||||||
 Frog   927 MAATGLNATSGQENPQDGDR-NYNHIGIMVEFAIALIGKLDLINKHSFNNFKLRVGINHGPVVAG 990

  Fly  1411 VIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITY 1475
            ||||.|||||||||.|||||||||||::..||||:|..::||..|::...||.:.|||||.:.||
 Frog   991 VIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETTKVLEKLGYKCERRGVIKVKGKGQLCTY 1055

  Fly  1476 FL 1477
            |:
 Frog  1056 FV 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	68/238 (29%)
		Guanylate_cyc	722..904	CDD:425528	110/181 (61%)
		Adcy_cons_dom	<949..1005	CDD:461877	13/85 (15%)
		Guanylate_cyc	1285..1479	CDD:425528	117/200 (59%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	68/246 (28%)
		Guanylate_cyc	270..453	CDD:425528	111/182 (61%)
		Adcy_cons_dom	483..588	CDD:461877	17/108 (16%)
		Guanylate_cyc	859..1057	CDD:425528	116/198 (59%)