Protein Alignment CG43373 and adcy6

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_002935166.2
• Gene: adcy6 / 100493933
• XenbaseID: XB-GENE-1011902
• Length: 1239
• Species: Xenopus tropicalis
• Alignment Length: 1547
• Identity: 551/1547 - (35%)
• Similarity: 785/1547 - (50%)
• Gaps: 397/1547 - (25%)

  Fly    10 GGAVAGGVGGGATHIFRS---------------LSSESQKREWSKRLSLRGMRHGGAAGGPGGSG 59
            |.||....||....|:|.               :|||:..   ...||.|..:...:...||.||
 Frog     4 GQAVRECAGGKRLDIYRCPIEISPNLPPNAIELVSSEAAA---LPHLSTRRNKCRVSPTQPGASG 65

  Fly    60 TSSLASSKEESKHRKFFSRSASLRQAGSGGGGVGVGGVVGGSGSHQASMELHVPGQEGRGTSSGA 124
              .|.:..:||| ..:||                  |::......:.:......|::|:..::..
 Frog    66 --KLPTPSQESK-MSWFS------------------GILVPKVDERKTAWGERNGKKGKRKNTSL 109

  Fly   125 GSPQTQTQPSTPK-----------KSNWEVIEHFNTSAKGGKAVVSSSLIAAGITRCNIDESMDS 178
            ..|:..:....|:           :..|:. :|:.....||...:.|  :|.|..    |..:..
 Frog   110 CGPRYMSCLQDPEMDRNNRNNFGLRCTWQE-DHYGKKGAGGDLGLKS--VALGFE----DGEVKG 167

  Fly   179 TNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRLNRIILRL 243
            :...||   .::...|..|.|.||:.                            |.|    .|::
 Frog   168 SKMGST---EVVGTEDGEQNLTPGEC----------------------------WVR----FLQV 197

  Fly   244 CSTHQFKNLQVEMLYQRYFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTSLLLEISE 308
            ..:.:|::.::|.||||||.:||||:.|.::..|:.:.|    .:|:|
 Frog   198 FQSKKFQSAKLERLYQRYFFQMNQSSLTMLMGALVLVCL----VMLIF----------------- 241

  Fly   309 IGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIAD 373
                                                                             
 Frog   242 ----------------------------------------------------------------- 241

  Fly   374 FEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVD 438
                                                                             
 Frog   242 ----------------------------------------------------------------- 241

  Fly   439 TATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNS 503
                                         |.|:
 Frog   242 -----------------------------HCTH-------------------------------- 245

  Fly   504 DPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLA 568
                |..|::.:.::.|  ::.:||.:|::|           ::...::.::.:|||:::....|
 Frog   246 ----GEPQVVYVSVLAV--AMALFLSLMVVC-----------NRNGFHQDYMWIVSYLVIAVLFA 293

  Fly   569 IEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAV 633
            ::|.....:.|..:..|....:..||:.||:||:|:|.|::.|::||.:||....|||     ..
 Frog   294 VQVLGVLMVTPRSASEGIWWSVFFIYIIYTLLPVRMRAAVLSGLILSSLHLIISWRLN-----LT 353

  Fly   634 EMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVL 698
            ::..|::|...::..|..|:.|:.||:|.|.:||:||.|||..|:|||..|||||||||||||||
 Frog   354 DIFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVL 418

  Fly   699 PRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARF 763
            |||||||||:||..:..|..|||||||:|:|||||||||.|||||:.||||:|||..||||||||
 Frog   419 PRHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARF 483

  Fly   764 DRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIH 828
            |:||||:||||||:|||||||||||||.|.|||||.||||:|||:||:|||||..||||||||||
 Frog   484 DKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIH 548

  Fly   829 TGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSY 893
            :||||||||||.||||||||||||||||||:||..||:|||..|||.|:||||||.|.|.|||:|
 Frog   549 SGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITSATLKYLNGDYEVEPGNGGERNAY 613

  Fly   894 LKDHQIETYLIVPGDIYRPHKKSR----NRLQVNGNI-----------------SKELRMMGHGT 937
            ||:|.|:|:|:......|..:|:.    .|.:.|.|.                 ||..|.||...
 Frog   614 LKEHDIKTFLVTGCSQKRKEEKAMMARLQRARANSNEGLTRVWVPERSFPRNKGSKAFRQMGIDE 678

  Fly   938 AQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEP 1002
            :.|...      :::.|.:|||||:|:|.|||||||||.||.:|.:..||.|:...||:||:.:.
 Frog   679 SSKDNR------NTQEALNPEDEVDEFLARAIDARSIDQLRKDHVKKFLLTFQTPDLEKKYSKKV 737

  Fly  1003 DRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKR 1067
            |.....|..|:|||......:::|:|..|.|.|.:.|...::|..::|:.|.:......|:.::.
 Frog   738 DDRFGGYVTCTLLVFCFICFIQIVIFPHSFLMLGVYTSVFIILASILFVCAIYSCIKLFPAALQG 802

  Fly  1068 FSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQM------ELLQRRRFWLDV------NG 1120
            .|.:|..:|..|.|....::.|:..:..:.||..:.|.:      ||....:| ::|      |.
 Frog   803 VSRKIVQSRTNSTLIGILTILLVFTSAFVNMFACNHRSLTDCAGQELNISYKF-VNVCHLRMLNY 866

  Fly  1121 SISLNDTELNTKMYDAEEPDCDF--YLAYNTFLLLTLLSMMSCATY-QV-------LRILLKLLL 1175
            |:|::....     |:::|.|:|  |..|:     .|||:::|:.: |:       |.:.:::|.
 Frog   867 SLSMDSPPC-----DSDKPLCNFPEYFNYS-----ILLSLLACSVFLQISSIGKLALMLFIQILY 921

  Fly  1176 LLLASGSYMACSSNL----------YSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQ 1230
            :::..|..:....|.          .:.:.::.:.|.:.:..|:: :..:.|..|:|||..|:.|
 Frog   922 IVIVEGPEVVLFDNYDLLVTVNALPINGTGDIEECLPSSKIALKF-VTPVILTVFVLALYLHAQQ 985

  Fly  1231 TEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCI 1295
            .|:|.||||:||||||.|||:||.||||||:||.||||..||.|||:||...|:||::.|:.|.:
 Frog   986 VESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVAAHFLAREHRNDELYYQSCECVAV 1050

  Fly  1296 LFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA 1360
            :||||.||||||||||.||||||||||||||||||||::|||:|:.:||||:.|:||||||||..
 Frog  1051 MFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKFKQLEKIKTIGSTYMAASGLND 1115

  Fly  1361 NTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNA 1425
            .|.|:...:|:||:||||::|.::::.:|.||||||:|:||:||||||||||||.|||||||||.
 Frog  1116 TTYDKEGKTHITALADYAMKLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNT 1180

  Fly  1426 VNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ||||||||||||.|.||||.::.|:|..:|:::.|||.:.|||||.|.||||
 Frog  1181 VNVASRMDSTGLPDCIQVTTDLYQVLAAKGYQMECRGVIKVKGKGEMTTYFL 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	75/196 (38%)
		Guanylate_cyc	722..904	CDD:425528	144/181 (80%)
		Adcy_cons_dom	<949..1005	CDD:461877	28/55 (51%)
		Guanylate_cyc	1285..1479	CDD:425528	129/193 (67%)
adcy6	XP_002935166.2	AC_N	89..440	CDD:318454	119/626 (19%)
		Guanylate_cyc	442..626	CDD:425528	145/183 (79%)
		Adcy_cons_dom	656..741	CDD:461877	34/90 (38%)
		Guanylate_cyc	1040..1233	CDD:425528	129/193 (67%)