Protein Alignment CG43373 and adcy5

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_031749309.1
• Gene: adcy5 / 100490464
• XenbaseID: XB-GENE-6035061
• Length: 1194
• Species: Xenopus tropicalis
• Alignment Length: 1008
• Identity: 481/1008 - (47%)
• Similarity: 655/1008 - (64%)
• Gaps: 77/1008 - (7%)

  Fly   525 LVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACC 589
            :.:::|:.:..::...|:.|.::.:.::.::.:..|:::.....:::.....::|..:.:|....
 Frog   202 VAYVVVLSVAILIIIVLIAICNRSSFHQDYMWISCYIVILVLFMVQIVGVLLLRPRSASDGIWWT 266

  Fly   590 IVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLT 654
            :..||..||:||:|:|.|:|.||:|||:||...::.|. .||.:    ::::...::.....|:.
 Frog   267 VFFIYTIYTLLPVRMRAAVISGIILSVIHLAISIKSNG-ADEFL----FKQITSNILIFSCTNIV 326

  Fly   655 GVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQF 719
            |:.||:|.|.:||:||.|||:||:|||.:||||||||||||||||||||||||.||..:..|..|
 Frog   327 GICTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMF 391

  Fly   720 HKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 784
            ||||||:|:|||||||||.|||||:.||||:|||..|||||||||:||||:||||||:|||||||
 Frog   392 HKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYC 456

  Fly   785 VSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSN 849
            ||||||.|.|||||.||||||||:||:|||||..||||||||||:||||||||||.|||||||||
 Frog   457 VSGLPEARGDHAHCCVEMGLDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSN 521

  Fly   850 DVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHK 914
            ||||||.||:||..||:||||.||..|:||||||.|.|.|||:|||.|.|||:|||.....|..:
 Frog   522 DVTLANQMEAGGKAGRIHITKATLNYLNGDYEVEPGAGGERNAYLKKHNIETFLIVRCSQKRKEE 586

  Fly   915 KS----RNRLQVNG--------NISKEL-RMMGHGTAQKHTSKFGFGD----SSESAKDPEDEVN 962
            |:    .||.:.|.        .|.:.. ..:|.....|...:.||.|    :::...:|||||:
 Frog   587 KAMIAKMNRQRTNSLGQNPVHWGIDRPFYNHLGSNQVSKEMKRMGFEDPKDKNTQENMNPEDEVD 651

  Fly   963 EYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVV 1027
            |:|.|||||||||.||:||.:..||.|::..||:||:.:.|.....|..|:.||.|....:::.:
 Frog   652 EFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACAFLVFLFICFVQITI 716

  Fly  1028 FQSSLLTLALSTGALLLLGFLV---FLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVAL 1089
            ...|...|.....:.|:|..::   .:.:|.::   .||.::..|.:|..:|..|......|:.|
 Frog   717 VPHSTFMLGFYLASFLILTTVLSVSLIYSCIRL---FPSPLQTLSRKIVQSRANSTAVGIFSIIL 778

  Fly  1090 IVLTTLLAMF------------QESG----RQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEE 1138
            :.|::.:.||            .|||    .....|.|.   |..|.|::     ..:.......
 Frog   779 VFLSSFINMFLCSNVNLRNCVASESGVPAANVTPCLLRN---LSQNYSLA-----TPSGFCGDPA 835

  Fly  1139 PDCDF--YLAYNTFLLLTLLSMMSCATYQVLRILLKLLLL-----------------LLASGSYM 1184
            |:|:|  |..|     ..|||:::|:.:..:..:.||:|:                 |..:...:
 Frog   836 PNCNFPEYFTY-----CILLSLLACSVFLQISSIGKLILMFIIELIYVLIVEIPQVVLFDNADLL 895

  Fly  1185 ACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEK 1249
            ..::::.....|::.........|: |:..|.|..|:|||..|:.|.|:|.||||:|||||||||
 Frog   896 VVANDIQWAGSELNCTGGVPRVPLK-IVTPIILTVFVLALYLHAQQVESTARLDFLWKLQATEEK 959

  Fly  1250 EDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNN 1314
            |:||.||||||:||.||||..||.|||:||:..|:||::.|:.|.::||||.||||||||||.||
 Frog   960 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANN 1024

  Fly  1315 EGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYAL 1379
            ||||||||||||||||||::||:.||.:||||:.|:||||||||..:|.|:...||:.|:||||:
 Frog  1025 EGVECLRLLNEIIADFDEIISEDEFRQLEKIKTIGSTYMAASGLNDSTYDKAGKSHIKALADYAM 1089

  Fly  1380 QLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVT 1444
            ::.|:::.:|.||||||:|:||:||||||||||||.|||||||||.|||||||||||:.:.||||
 Frog  1090 RMMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVT 1154

  Fly  1445 QEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            .::||:|....::|.|||.|.|||||.|:||||
 Frog  1155 ADLQQVLAANNYKLECRGVVKVKGKGEMMTYFL 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	71/194 (37%)
		Guanylate_cyc	722..904	CDD:425528	145/181 (80%)
		Adcy_cons_dom	<949..1005	CDD:461877	29/59 (49%)
		Guanylate_cyc	1285..1479	CDD:425528	129/193 (67%)
adcy5	XP_031749309.1	AC_N	1..392	CDD:318454	71/194 (37%)
		Guanylate_cyc	394..576	CDD:425528	145/181 (80%)
		Adcy_cons_dom	602..695	CDD:461877	34/92 (37%)
		Guanylate_cyc	995..1189	CDD:425528	129/193 (67%)