DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	128/533 - (24%)
Similarity:	208/533 - (39%)	Gaps:	170/533 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 EKRSLQD--AGLVKGGGIQ--------------------TQLIVDTATDDDADVYTVASDDDDDV 458
            |:..|||  .|:||....|                    ||.:::.....:.|.|    :|.|..
Frog   138 EREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKDTREEDFY----EDQDRF 198

  Fly   459 DGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDES 523
            :...:..|:...||                                    :.:..|..:| .|..
Frog   199 EENGTQESRISPYT------------------------------------FCKAFPFHIM-FDRD 226

  Fly   524 VLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYV-----ILGTFLAIEVAVSYAMQPSKSF 583
            :.|     ..||               |.|:.||....     :|..|..:...:..      ||
Frog   227 LFV-----TQCG---------------NAIYRVLPQLQPGNCNLLSVFSLVRPHIDI------SF 265

  Fly   584 NGSACCIVLIYMTYTMLPLRLREALIG-----------GILLSVVHLYTCLRLNAMQDEAVEMIH 637
            :|     :|.::. |:..||.:|.|:.           |..:|      ||||..      :||:
Frog   266 HG-----ILSHIN-TVFVLRSKEGLLDVEKSESEDELTGTEIS------CLRLKG------QMIY 312

  Fly   638 WEE-----LLCTLVALLLANLT--GVY-THWPKEKAQRKAFI-------ETRQCIEARLRTQR-- 685
            ..|     .||:...:.|.:||  |:| :..|...|.|...:       |.:...|..:.|.|
Frog   313 LPEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQ 377

  Fly   686 --------ENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHK--IYIQRHENVSILFADICGF 740
                    |.::.:.||.||||..||.|::            ||  :..:|::||:|||:.|.||
Frog   378 HTLRALEDEKKKTDTLLYSVLPPSVANELR------------HKRPVPAKRYDNVTILFSGIVGF 430

  Fly   741 -TSLSDQCTAE---ELVRLLNELFARFDRLAAEH---HCLRIKLLGDCYYCVSGLPEPRPDHAHC 798
             |..|...:.|   ::|.|||:::.|||.|....   :..:::.:||.|..|||:|||...||..
Frog   431 NTFCSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARS 495

  Fly   799 AVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIP 863
            ...:.|||::....| :|...:|.:.:|||||.|..||:|....::.::.|.|.|.:..|:.|..
Frog   496 ICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEK 559

  Fly   864 GRVHITKETLKCL 876
            |::::::.|.:||
Frog   560 GKINVSEYTYRCL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	51/237 (22%)
		CYCc	686..881	CDD:214485	67/200 (34%)
		Guanylate_cyc	722..895	CDD:278633	55/162 (34%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902	8/27 (30%)
		HNOBA	207..406	CDD:369471	55/279 (20%)
		Guanylate_cyc	412..605	CDD:306677	55/162 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910