DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gucy1a2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	349	Identity:	88/349 - (25%)
Similarity:	153/349 - (43%)	Gaps:	78/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 RLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQR 667
            ||.|.:..|:.||.:.::     :|.:|                .:|:...........|...:.
Zfish   304 RLEELMGRGLHLSDIPIH-----DATRD----------------VILVGEQAKAQDGLKKRMDKL 347

  Fly   668 KAFIE-TRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVS 731
            ||.:| |.|.:|      .|.::...||.|:.|..||..:..   |.|       :..::.::|:
Zfish   348 KATLEKTHQALE------EEKRRTVDLLYSIFPGDVAQRLWQ---GLP-------VQAKKFDDVT 396

  Fly   732 ILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHA 796
            :||:||.|||::..|||..:::.:||||:.|||.........:|:.:||.|....||......||
Zfish   397 MLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHRKIDSHA 461

  Fly   797 HCAVEMGLDMIDAIALVREVMAVN---VNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHME 858
            .....|.|.|::   |..||:..:   :.:|:|||:|.|..||:|::..::.::.|:||||:..|
Zfish   462 KPIALMALKMME---LSEEVLTPDGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNVTLASKFE 523

  Fly   859 SGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVN 923
            ||..|..::::..|.:.|..|                    .::..:|          |:|.::.
Zfish   524 SGSHPRCINVSPTTYQLLRDD--------------------RSFTFIP----------RSRQELP 558

  Fly   924 GNISKEL----RMMGHGTAQKHTS 943
            .|..||:    ..:..|.:|.|.|
Zfish   559 DNFPKEIPGICYFLEAGKSQSHAS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	25/117 (21%)
		CYCc	686..881	CDD:214485	62/197 (31%)
		Guanylate_cyc	722..895	CDD:278633	53/175 (30%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810