DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and adcy8

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1240	Identity:	461/1240 - (37%)
Similarity:	658/1240 - (53%)	Gaps:	190/1240 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 ASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAG-----VATDNSDPPL--G 508
            ||.|:....|.|...:...:.:.|..:.......||     :||:.|     .|..|||..|  |
Zfish    61 ASPDEAHTQGSRKHSAGRTSVSDRHNNGGTKVFPER-----SSSDLGFLQIDCAPSNSDFFLSWG 120

  Fly   509 Y---GQLIPLI-----------------LMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEI 553
            |   |.:.|.:                 |.|..:||:|..|:.::..:....|...|:...|:.|
Zfish   121 YTYRGVIFPTLRYAFKSRDLERLYQRYFLGQRRKSVVVMNILDVVTKLTLLVLHLTLASTPMDPI 185

  Fly   554 FLVLVSYVILGTFLAIEVAVSYAMQPSK--------SFNGSACCIVL------------------ 592
                 ..::||.|..|||.:...:...|        .::|:...:.:
Zfish   186 -----KGMLLGFFTGIEVVICALVVVRKDTSSHGYLQYSGAVTWVAMATQILATGLGYGLLGDGI 245

  Fly   593 ------IYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEM-------IHWEELLCT 644
                  ::.||:||||.|..|::.|:|.|.:|:            |:::       |...:||..
Zfish   246 GYVLFTLFATYSMLPLPLTWAIVAGLLTSALHI------------ALQLLVPPRAQISTNQLLAQ 298

  Fly   645 LVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDD 709
            ::..|..|..|::..:..::|||:||:|||:|||||||.:.|||:||||:||||||.|.:||.:|
Zfish   299 VLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMIND 363

  Fly   710 IAGQPRDT---QFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHH 771
            :.....:|   |||:|||.|:|||||||||:.|||:||...:|:||||:||||||||||||.|||
Zfish   364 MTNVEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHH 428

  Fly   772 CLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGV 836
            |||||:|||||||||||||||||||||.|||||.||..|..||.....:::||:|||:|.|.|||
Zfish   429 CLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGV 493

  Fly   837 LGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIET 901
            |||.||||||||.||.:||.:||||||||:||:|..|.||:||||||.|.|.:||.:|:.|.|||
Zfish   494 LGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLRRHNIET 558

  Fly   902 YLI---------VPGDIYR------PHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSS 951
            :||         :|.||.|      .|:.| |.....|..|.||..  |....|..:.......|
Zfish   559 FLIKQPEESLLTLPEDIMRDSTNQSDHRTS-NTSFTEGTWSPELPF--HNIVGKQNTLAALTRHS 620

  Fly   952 ES-----------AKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRM 1005
            .:           .:....|:|..:...|..||.|.||.||.....|.|::.:||.||:...|.:
Zfish   621 INLLPNHLAQALHVRAGSQEINARMQSTIALRSGDKLRQEHISPFSLTFREALLEHKYSQMRDEV 685

  Fly  1006 LCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSL 1070
            ......|:.:||...:.::.::..:.::|:.:....|:||...:.:|...:....||..:::...
Zfish   686 FKSNLVCAFIVLFFITGIQSLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKCLPLVLRKACC 750

  Fly  1071 RIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYD 1135
            .::.......:..|.|:.:..|..::.:               .|.|.:.|.|..:...|.   .
Zfish   751 WVNETYAARNVVIFLSILINFLAAMINI---------------LWCDFDKSGSFRNQTFNA---S 797

  Fly  1136 AEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSR--SREMS 1198
            |..||..||..|  |:...:|:|::||.:..|..:|||.:||:....|...:...|:.  .|..:
Zfish   798 ASIPDICFYPEY--FVFTGVLAMVTCAVFLRLNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDT 860

  Fly  1199 QELANEEALLRYIIDSIFLFA-FMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKL 1262
            ..|...::.|.....|:.|.| |:||:.:|..|.|.|.||||:|::||.||..:|..|:.:|..:
Zfish   861 LTLNQSKSFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMRELREHNENM 925

  Fly  1263 LENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEII 1327
            |.||||.|||.|||.:::..::||.:..|:|.::|||||.|::||.:.|.||:||||||||||||
Zfish   926 LRNILPSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEII 990

  Fly  1328 ADFDELLSEERFRCIEKIKSTGATYMAASGLT--ANTCDRVNFSHVTAMADYALQLFDKIEEVNM 1390
            |||||||.||||:.|||||:.|:||||.|||:  ...|:. .:.|:.|:||:|:.|.:.|:|:|.
Zfish   991 ADFDELLGEERFQDIEKIKTIGSTYMAVSGLSPEKQQCED-KWGHLCALADFAIALNESIQEINK 1054

  Fly  1391 HSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRG 1455
            ||||||::|||:..|.||||||||.||||||||..||:||||||||:...||:.:|...||..||
Zfish  1055 HSFNNFQLRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERG 1119

  Fly  1456 FELTCRGSVDVKG----KGSMITYFLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLDSGTAT 1516
            |....||.:.|||    :|.:.|:|:.||              |:|.   .|..:|.||
Zfish  1120 FAFEYRGEIYVKGISEQEGKIRTHFMIGR--------------VQPN---PLILQPRKL------ 1161

  Fly  1517 EKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQRRKSLCRQHNISSSFGTTVSSSTGITPS 1581
                        |.|..  |.:..:.:   :|:|..|::|.:..::|.|.......:..|.:.|.
Zfish  1162 ------------TGQYS--LAAVVLGL---VQSLNRQKQKQILNENNNSGIMKGHYNRRTLLAPG 1209

  Fly  1582 ISNSS 1586
            .|::|
Zfish  1210 GSDTS 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	69/238 (29%)
		CYCc	686..881	CDD:214485	136/197 (69%)
		Guanylate_cyc	722..895	CDD:278633	123/172 (72%)
		DUF1053	<949..1005	CDD:283888	18/66 (27%)
		CYCc	1259..1455	CDD:214485	114/197 (58%)
		Guanylate_cyc	1285..1479	CDD:278633	113/199 (57%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	70/255 (27%)
		CYCc	340..538	CDD:214485	136/197 (69%)
		Guanylate_cyc	379..563	CDD:278633	130/183 (71%)
		DUF1053	592..685	CDD:283888	24/94 (26%)
		CYCc	919..1123	CDD:214485	117/204 (57%)
		Guanylate_cyc	948..1147	CDD:278633	113/199 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810