DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and gucy1a2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	312	Identity:	84/312 - (26%)
Similarity:	145/312 - (46%)	Gaps:	64/312 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 KEKAQRKAFIE-TRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQ 725
            |...:.||.:| |.|.:|      .|.::...||.|:.|..||.::.:..:.|.|
Frog   447 KRMDKLKATLEKTHQALE------EEKKKTVDLLYSIFPGDVAQQLWEGKSVQAR---------- 495

  Fly   726 RHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPE 790
            :.::|::||:||.|||::..|||..:::.:||||:.|||.........:::.:||.|...:||..
Frog   496 KFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGLLR 560

  Fly   791 PRPDHAHCAVEMGLDMIDAIALVREVMAVN---VNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVT 852
            ....||.....|.|.|::   |..||:..:   :.||:|||:|.|..||:|:...::.::.|:||
Frog   561 QSNSHAKPIALMALKMME---LSEEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVT 622

  Fly   853 LANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSR 917
            ||:..|||..|.|::::..|       |::           |||.  ..:..||          |
Frog   623 LASKFESGSHPRRINVSPTT-------YQL-----------LKDE--ANFHFVP----------R 657

  Fly   918 NRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAI 969
            :|.::..|..||:..:.:           |.::....|.|:..:....||.:
Frog   658 SREELPDNFPKEIPGICY-----------FLEADSGQKQPKPSLTSVRMRKV 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	16/58 (28%)
		CYCc	686..881	CDD:214485	61/197 (31%)
		Guanylate_cyc	722..895	CDD:278633	53/175 (30%)
		DUF1053	<949..1005	CDD:283888	4/21 (19%)
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902
		HNOBA	296..486	CDD:369471	14/44 (32%)
		Guanylate_cyc	492..679	CDD:306677	66/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910