DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33158 and EFTUD2

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001245282.1	Gene:	EFTUD2 / 9343	HGNCID:	30858	Length:	972	Species:	Homo sapiens

Alignment Length:	1060	Identity:	284/1060 - (26%)
Similarity:	466/1060 - (43%)	Gaps:	235/1060 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VVEGSDLVLLQRRRQQVRNICILAHVDHGKTTLADSLV-ASNGIISQRMAGKLRYLDNRSDEQER 66
            |.|...|..|....:.:||:.:..|:.||||...|.|: .::..|.:|....|.|.|....||||
Human   113 VYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQER 177

  Fly    67 GITMKSSSISLYYQEAEEMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQ 131
            |:.:||:.:::...:.:    ...||.|::|:||||:||.||:..:|:.||.::.:|..|||...
Human   178 GVGIKSTPVTVVLPDTK----GKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLN 238

  Fly   132 TRACLRQIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDI 196
            |...::...:|:|...:.:||:||||||.::.|.|||:.|..::::||.:: |::::
Human   239 TERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLI-SMYST-------- 294

  Fly   197 TKKDNYESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRL-EMSRKDLENVLWG 260
                          |..|..||..|||.|.|:.....|::..||.:||... :::.::....|||
Human   295 --------------DENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWG 345

  Fly   261 DFYYNSKKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIA-IRKDKD-KLPGIAEKLGLKLATRD 323
            |.|:|.|.::....|...:.:..||:|:||   .||.|:| :..|.| .||...::||:.|...:
Human   346 DIYFNPKTRKFTKKAPTSSSQRSFVEFILE---PLYKILAQVVGDVDTSLPRTLDELGIHLTKEE 407

  Fly   324 LRLT-DPKLQI--KAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPANVDLSSLPPETL 385
            |:|. .|.|::  |...|::    ...:.|.:||:|.| |:..:......|...||        .
Human   408 LKLNIRPLLRLVCKKFFGEF----TGFVDMCVQHIPSP-KVGAKPKIEHTYTGGVD--------S 459

  Fly   386 ELKESFTSCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEERKQQSEQA 450
            :|.|:.:.||.:.. ::...:||..              ||..||
Human   460 DLGEAMSDCDPDGP-LMCHTTKMYS--------------TDDGVQ-------------------- 489

  Fly   451 ELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGM------ELFNLSPK 509
                                               |.||.||.|||:..|.      |.:.|..:
Human   490 -----------------------------------FHAFGRVLSGTIHAGQPVKVLGENYTLEDE 519

  Fly   510 HDPRQPTHRKEGEAPYASRV-TIGDLYMFMGGELQLLDEVPAGNIVGIGGLESHIVKTATLS--- 570
            .|               |:: |:|.|::.:......::.|||||.|.|.|::..||||||::
Human   520 ED---------------SQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPR 569

  Fly   571 SSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSVAPTGEHVITTLGE 635
            .:.:...|..|....|.::::|:|||.|.::||::.||:.:|::...:...|..:|||||...||
Human   570 GNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGE 634

  Fly   636 VHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVSKKIAVQQTLN 700
            ::::..:|||.:.|::|.:.|:.|:|:|.||:|..:::....|                   |.|
Human   635 LYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAE-------------------TPN 680

  Fly   701 KLGTLKVIAVPLPAEAVELLETHSEFFKELAAIPRNQLLSEKWTALLASIKVKLIAALKDLQLFG 765
            |...:.:||.||.              |.||....|:::...|..             |.|..|.
Human   681 KKNKITMIAEPLE--------------KGLAEDIENEVVQITWNR-------------KKLGEFF 718

  Fly   766 LSTLSPEELVNR-IWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPR-----KDFN 824
            .:....:.|..| |||.||...|.|||:                 |..:.|:.|..     ||
Human   719 QTKYDWDLLAARSIWAFGPDATGPNILV-----------------DDTLPSEVDKALLGSVKD-- 764

  Fly   825 SSLVNGFQITSVAGPLCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQVLTAAKEVCRQAFQNQ 889
             |:|.|||..:..||||:|.::.|.|.:|:..:..  |.|:..|   ||::..|:.|...||...
Human   765 -SIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQ--EPLHRGG---GQIIPTARRVVYSAFLMA 823

  Fly   890 PQRLVTPMYSCNIVVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESFNFAQEMR 954
            ..||:.|.|...:...|:.:..:|.|:.||.|.:.......||..:.:...:|.|:||.|..::|
Human   824 TPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLR 888

  Fly   955 KQTSGLACPQLMFSHWEVIDIDPFWLPTTEEELMHFGEKADSANRAKVYMDSVRRRKGL------ 1013
            ..|.|.|....:|.||:::..||.........|    |...:.:.|:.:|...||||||
Human   889 THTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPL----EPQPAPHLAREFMIKTRRRKGLSEDVSI 949

  Fly  1014 ---FVDEQVVEHAEKQRTLS 1030
               |.|..::|.|::...|:
Human   950 SKFFDDPMLLELAKQDVVLN 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	276/1032 (27%)
		EF2	20..249	CDD:206672	73/230 (32%)
		EF2_II	485..572	CDD:293913	30/96 (31%)
		EF2_snRNP_III	587..658	CDD:293918	24/70 (34%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	63/246 (26%)
		eEF2_snRNP_like_C	896..974	CDD:239763	22/77 (29%)
EFTUD2	NP_001245282.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		EFTUD2	4..110	CDD:406414
		FusA	122..954	CDD:357662	276/1034 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820