DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33158 and MEF2

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_012433.1	Gene:	MEF2 / 853342	SGDID:	S000003638	Length:	819	Species:	Saccharomyces cerevisiae

Alignment Length:	947	Identity:	197/947 - (20%)
Similarity:	339/947 - (35%)	Gaps:	328/947 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSD----EQERGITMKSSSISLY 78
            :||||.|:||:|.||||..:.::...||  .:..|.:...|..:|    |:.||||::|::||..
Yeast    40 KVRNIGIIAHIDAGKTTTTERMLYYAGI--SKHIGDVDTGDTITDFLEQERSRGITIQSAAISFP 102

  Fly    79 YQEAEEMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLRQIYEEQ 143
            ::..        :.|||||:|||:||:.||..|:::.|..:|::|.|.||..||....:|   .:
Yeast   103 WRNT--------FAINLIDTPGHIDFTFEVIRALKVIDSCVVILDAVAGVEAQTEKVWKQ---SK 156

  Fly   144 LKP-VLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILA-----KEDITKKDN- 201
            .|| :..:||:||         :.|.|: ..|.:.:|..:.......:|.     ::..|..|.
Yeast   157 SKPKICFINKMDR---------MGASFN-HTVNDLINKFMRGTTTKPVLVNIPYYRKQPTSNDYV 211

  Fly   202 YESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRLEMSRKDLENVLWGDFYYNS 266
            ::..::.|:...|.::|.:.:.|.....||.:             ||...:..|:::
Yeast   212 FQGVIDVVNGKRLTWNPENPDEIIVDELDGTS-------------LEQCNRCRESMI-------- 255

  Fly   267 KKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPGIAEKLGLKLATRDLRLTDPKL 331
               |.|....|.     .||..||.....|.                    |::.:.|..:..||
Yeast   256 ---ETLTEYDED-----LVQHFLEEAEGDYS--------------------KVSAQFLNASIRKL 292

  Fly   332 QIKAVLGQWLPI----------DKSVLHMVIQHVPPPHKISDERAQRLLYPANVDLSSLPPETLE 386
            .:|.::   :|:          .:.:|..::.::|.              |...:|..|..:|:.
Yeast   293 TMKNMI---VPVLCGASFKNIGVQPLLDAIVNYLPS--------------PIEAELPELNDKTVP 340

  Fly   387 LK-ESFTSCDANSSN----VIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEERKQQ 446
            :| :....|..|::.    .:||                 |.:||
Yeast   341 MKYDPKVGCLVNNNKNLCIALAF-----------------KVITD-------------------- 368

  Fly   447 SEQAELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGMELFNLSPKHD 511
                                         |....|      .|.|::||||..|..::|.:
Yeast   369 -----------------------------PIRGKQ------IFIRIYSGTLNSGNTVYNST---- 394

  Fly   512 PRQPTHRKEGEAPYASRVTIGDLYMFMGGELQLLDEVPAGNIVGIGG--LESHIVKTATLSS--- 571
                    .||     :..:|.|.:...|..|.::.:.||.|..:.|  :|::|....||.:
Yeast   395 --------TGE-----KFKLGKLLIPHAGTSQPVNILTAGQIGLLTGSTVENNISTGDTLITHSS 446

  Fly   572 ------SLDCTSFSELSV----MATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSV-APT 625
                  |||......|.:    :..|:..|:|||....:...:.:.|..|...|..:.:|. ..|
Yeast   447 KKDGLKSLDKKKELTLKINSIFIPPPVFGVSIEPRTLSNKKSMEEALNTLITEDPSLSISQNDET 511

  Fly   626 GEHVITTLGEVHVE----KCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDM----------- 675
            |:.|:..:||:|:|    :.|:||     |..|...:.:||::|||.....::.
Yeast   512 GQTVLNGMGELHLEIAKDRLVNDL-----KADVEFGQLMVSYKETINSETNIETYESDDGYRFSL 571

  Fly   676 ------------------VNEAIVKTAE----DKDVSKKIAVQQTLNKL-----------GTLKV 707
                              |||..:...:    ||:...:::.:..||.:           |  |:
Yeast   572 SLLPNSDALPNCLAYPLGVNENFLIMEKNGNWDKEWKYQVSFESILNSIIASCIVGLQRGG--KI 634

  Fly   708 IAVPLPAEAVEL---------LETHSEFFK---ELAAIPRNQLLSEKWTALLASIKVKLI----- 755
            ...||.|.::::         :||..|..|   .|.....|.|..||:..|...:.:.|.
Yeast   635 ANFPLYACSIKINSDWSVPPDIETPQEILKITRNLIFKALNDLKPEKYNLLEPIMNLDLTIPQSD 699

  Fly   756 --AALKDL------QLF-----------GLSTLSPEELVNRIWALGPRNCGTNILLNLSDYEQPD 801
              ..|:||      |:.           |.||.:..|..|||:.  |.:..|. |....|.:...
Yeast   700 VGTVLQDLTGARKAQILSIEDESSVSNSGASTCNSPENSNRIYI--PSDAVTT-LHATKDKKNTQ 761

  Fly   802 FWSSHAKS--------------DTDIRSKTDPRKDFN 824
            ..||:.|.              ...:||.:..|.:||
Yeast   762 ETSSNVKKIIKAKVPLREITTYTNKLRSLSQGRGEFN 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	197/947 (21%)
		EF2	20..249	CDD:206672	66/239 (28%)
		EF2_II	485..572	CDD:293913	22/97 (23%)
		EF2_snRNP_III	587..658	CDD:293918	21/75 (28%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	51/261 (20%)
		eEF2_snRNP_like_C	896..974	CDD:239763
MEF2	NP_012433.1	FusA	37..817	CDD:223556	197/947 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810